16112
2017
eng
i1-i3
Supplement
18
conferenceobject
Oxford University Press
1
2018-04-25
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--
PET-Guided Histological Characterization of Myocardial Infiltrating Cells in a Rat Model of Myocarditis
No abstract available.
European Heart Journal - Cardiovascular Imaging
2047-2404
10.1093/ehjci/jex071
urn:nbn:de:bvb:20-opus-161127
This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of record . Eur Heart J Cardiovasc Imaging. ISSN: 2047-2404. Supplement, vol. 18, i1-i3, May 2017 is available online at: 10.1093/ehjci/jex071.
European Heart Journal - Cardiovascular Imaging, Volume 18, Issue suppl_1, May 2017, Pages i1–i3, https://doi.org/10.1093/ehjci/jex071
701983
Johns Hopkins School of Medicine, Baltimore, MD, U.S.
Deutsches Urheberrecht
Rudolf Werner
Hiroshi Wakabayashi
Roland Jahns
Süleyman Ergün
Valerie Jahns
Takahiro Higuchi
deu
swd
Myokarditis
eng
uncontrolled
positron emission tomography
eng
uncontrolled
myocarditis
eng
uncontrolled
PET
eng
uncontrolled
18F-FDG
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für Pharmakologie und Toxikologie
Institut für Anatomie und Zellbiologie
Medizinische Klinik und Poliklinik I
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16112/Werner_Rudolf_Myocarditis.pdf
16560
2018
eng
1-8
article
1
2018-07-24
--
--
Longitudinal \(^{18}\)F-FDG PET imaging in a Rat Model of Autoimmune Myocarditis
Aims: Although mortality rate is very high, diagnosis of acute myocarditis remains challenging with conventional tests. We aimed to elucidate the potential role of longitudinal 2-Deoxy-2-\(^{18}\)F-fluoro-D-glucose (\(^{18}\)F-FDG) positron emission tomography (PET) inflammation monitoring in a rat model of experimental autoimmune myocarditis.
Methods and results: Autoimmune myocarditis was induced in Lewis rats by immunizing with porcine cardiac myosin emulsified in complete Freund’s adjuvant. Time course of disease was assessed by longitudinal \(^{18}\)F-FDG PET imaging. A correlative analysis between in- and ex vivo \(^{18}\)F-FDG signalling and macrophage infiltration using CD68 staining was conducted. Finally, immunohistochemistry analysis of the cell-adhesion markers CD34 and CD44 was performed at different disease stages determined by longitudinal \(^{18}\)F-FDG PET imaging. After immunization, myocarditis rats revealed a temporal increase in 18F-FDG uptake (peaked at week 3), which was followed by a rapid decline thereafter. Localization of CD68 positive cells was well correlated with in vivo \(^{18}\)F-FDG PET signalling (R\(^2\) = 0.92) as well as with ex vivo 18F-FDG autoradiography (R\(^2\) = 0.9, P < 0.001, respectively). CD44 positivity was primarily observed at tissue samples obtained at acute phase (i.e. at peak 18F-FDG uptake), while CD34-positive staining areas were predominantly identified in samples harvested at both sub-acute and chronic phases (i.e. at \(^{18}\)F-FDG decrease).
Conclusion: \(^{18}\)F-FDG PET imaging can provide non-invasive serial monitoring of cardiac inflammation in a rat model of acute myocarditis.
European Heart Journal Cardiovascular Imaging
2047-2404
10.1093/ehjci/jey119
urn:nbn:de:bvb:20-opus-165601
Johns Hopkins School of Medicine
701983
European Heart Journal - Cardiovascular Imaging (2018) 0, 1–8 doi:10.1093/ehjci/jey119
CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International
Rudolf Werner
Hiroshi Wakabayashi
Jochen Bauer
Claudia Schütz
Christina Zechmeister
Nobuyuki Hayakawa
Mehrbod S. Javadi
Constantin Lapa
Roland Jahns
Süleyman Ergün
Valerie Jahns
Takahiro Higuchi
eng
uncontrolled
positron emission tomography
deu
swd
Myokarditis
eng
uncontrolled
myocarditis
eng
uncontrolled
inflammation
eng
uncontrolled
18F-FDG
eng
uncontrolled
PET
eng
uncontrolled
personalized treatment
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für Pharmakologie und Toxikologie
Institut für Anatomie und Zellbiologie
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16560/Werner_EHJ_Cardiovascular_Imaging_2018.pdf