17463
2019
eng
410-411
5
44
article
1
2018-12-31
--
--
Novel functional renal PET imaging with 18F-FDS in human subjects
The novel PET probe 2-deoxy-2-18F-fluoro-D-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in two human volunteers. 18F-FDS was produced by a simple one-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.
Clinical Nuclear Medicine
0363-9762
urn:nbn:de:bvb:20-opus-174634
Johns Hopkins School of Medicine
Clinical Nuclear Medicine (2019) 44, 5, p. 410-411. doi: 10.1097/RLU.0000000000002494
701983
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Rudolf A. Werner
Alvaro A. Ordonez
Julian Sanchez-Bautista
Charles Marcus
Constantin Lapa
Steven P. Rowe
Martin G. Pomper
Jeffrey P. Leal
Martin A. Lodge
Mehrbod S. Javadi
Sanjay K. Jain
Takahiro Higuchi
eng
uncontrolled
2-deoxy-2-18F-fluoro-D-sorbitol
deu
swd
Positronen-Emissions-Tomografie
eng
uncontrolled
18F-FDS
eng
uncontrolled
renal imaging
eng
uncontrolled
Positron-Emission Tomography
eng
uncontrolled
split renal function
eng
uncontrolled
kidney
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/17463/Rudolf_Werner_Novel_Functional_Renal_PET_Imagin_Clinical_Nuclear_Medicine.pdf
26009
2021
eng
6105-6119
12
11
article
1
2022-03-14
--
--
Current and future perspectives on functional molecular imaging in nephro-urology: theranostics on the horizon
In recent years, a paradigm shift from single-photon-emitting radionuclide radiotracers toward positron-emission tomography (PET) radiotracers has occurred in nuclear oncology. Although PET-based molecular imaging of the kidneys is still in its infancy, such a trend has emerged in the field of functional renal radionuclide imaging. Potentially allowing for precise and thorough evaluation of renal radiotracer urodynamics, PET radionuclide imaging has numerous advantages including precise anatomical co-registration with CT images and dynamic three-dimensional imaging capability. In addition, relative to scintigraphic approaches, PET can allow for significantly reduced scan time enabling high-throughput in a busy PET practice and further reduces radiation exposure, which may have a clinical impact in pediatric populations. In recent years, multiple renal PET radiotracers labeled with C-11, Ga-68, and F-18 have been utilized in clinical studies. Beyond providing a precise non-invasive read-out of renal function, such radiotracers may also be used to assess renal inflammation. This manuscript will provide an overview of renal molecular PET imaging and will highlight the transformation of conventional scintigraphy of the kidneys toward novel, high-resolution PET imaging for assessing renal function. In addition, future applications will be introduced, e.g. by transferring the concept of molecular image-guided diagnostics and therapy (theranostics) to the field of nephrology.
Theranostics
10.7150/thno.58682
urn:nbn:de:bvb:20-opus-260090
publish
Theranostics (2021) 11:12, 6105-6119. doi:10.7150/thno.58682
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Yoshitaka Toyama
Rudolf A. Werner
Camilo A. Ruiz-Bedoya
Alvaro A. Ordonez
Kei Takase
Constantin Lapa
Sanjay K. Jain
Martin G. Pomper
Steven P. Rowe
Takahiro Higuchi
eng
uncontrolled
glomerular filtration rate
eng
uncontrolled
renal
eng
uncontrolled
kidney
eng
uncontrolled
renal function
eng
uncontrolled
positron emission tomography
eng
uncontrolled
nephrology
eng
uncontrolled
urology
eng
uncontrolled
molecular imaging
eng
uncontrolled
theranostics
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Deutsches Zentrum für Herzinsuffizienz (DZHI)
Förderzeitraum 2021
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/26009/v11p6105.pdf