16516
2016
eng
569
10
article
1
2018-07-20
--
--
Cognitive Processing in Non-Communicative Patients: What Can Event-Related Potentials Tell Us?
Event-related potentials (ERP) have been proposed to improve the differential diagnosis of non-responsive patients. We investigated the potential of the P300 as a reliable marker of conscious processing in patients with locked-in syndrome (LIS). Eleven chronic LIS patients and 10 healthy subjects (HS) listened to a complex-tone auditory oddball paradigm, first in a passive condition (listen to the sounds) and then in an active condition (counting the deviant tones). Seven out of nine HS displayed a P300 waveform in the passive condition and all in the active condition. HS showed statistically significant changes in peak and area amplitude between conditions. Three out of seven LIS patients showed the P3 waveform in the passive condition and five of seven in the active condition. No changes in peak amplitude and only a significant difference at one electrode in area amplitude were observed in this group between conditions. We conclude that, in spite of keeping full consciousness and intact or nearly intact cortical functions, compared to HS, LIS patients present less reliable results when testing with ERP, specifically in the passive condition. We thus strongly recommend applying ERP paradigms in an active condition when evaluating consciousness in non-responsive patients.
Frontiers in Human Neuroscience
10.3389/fnhum.2016.00569
urn:nbn:de:bvb:20-opus-165165
Front. Hum. Neurosci. 10:569.
Zulay R. Lugo
Lucia R. Quitadamo
Luigi Bianchi
Fréderic Pellas
Sandra Veser
Damien Lesenfants
Ruben G. L. Real
Cornelia Herbert
Christoph Guger
Boris Kotchoubey
Donatella Mattia
Andrea Kübler
Steven Laureys
Quentin Noirhomme
eng
uncontrolled
P300
eng
uncontrolled
event-related potentials
eng
uncontrolled
locked-in syndrome
eng
uncontrolled
vegetative state
eng
uncontrolled
unresponsive wakefulness syndrome
eng
uncontrolled
minimally conscious state
Psychologie
open_access
Institut für Psychologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16516/052_Lugo_FRONTIERS IN HUMAN NEUROSCIENCE.pdf
11555
2014
eng
654
8
article
1
2015-07-11
--
--
Task instructions modulate the attentional mode affecting the auditory MMN and the semantic N400
Event-related potentials (ERPs) have been proven to be a useful tool to complement clinical assessment and to detect residual cognitive functions in patients with disorders of consciousness. These ERPs are of ten recorded using passive or unspecific instructions. Patient data obtained this way are then compared to data from healthy participants, which are usually recorded using active instructions. The present study investigates the effect of attentive modulations and particularly the effect of activevs. passive instruction on the ERP components mismatch negativity (MMN) and N400. A sample of 18 healthy participants listened to three auditory paradigms: anoddball, aword priming, and a sentence paradigm. Each paradigm was presented three times with different instructions: ignoring auditory stimuli, passive listening, and focused attention on the auditory stimuli. After each task, the participants indicated their subjective effort. The N400 decreased from the focused task to the passive task, and was extinct in the ignore task. The MMN exhibited higher amplitudes in the focused and passive task compared to the ignore task. The data indicate an effect of attention on the supratemporal component of the MMN. Subjective effort was equally high in the passive and focused tasks but reduced in the ignore task. We conclude that passive listening during EEG recording is stressful and attenuates ERPs, which renders the interpretation of the results obtained in such conditions difficult.
Frontiers in Human Neuroscience
10.3389/fnhum.2014.00654
25221494
urn:nbn:de:bvb:20-opus-115553
Frontiers in Human Neuroscience 8:654. doi:10.3389/fnhum.2014.00654
247919
Helena Erlbeck
Andrea Kübler
Boris Kotchoubey
Sandra Veser
eng
uncontrolled
ERP
eng
uncontrolled
priming
eng
uncontrolled
selective attention
eng
uncontrolled
event-related potentials
eng
uncontrolled
vigilance decrement
eng
uncontrolled
brain potentials
eng
uncontrolled
vegetative state
eng
uncontrolled
consciousness
eng
uncontrolled
component
eng
uncontrolled
predicts recovery
eng
uncontrolled
mismatch negativity
eng
uncontrolled
attention
eng
uncontrolled
instruction
eng
uncontrolled
N400
eng
uncontrolled
MMN
Psychologie
open_access
Institut für Psychologie
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/11555/053_Erlbeck_FRONTIERS_IN_HUMAN_NEUROSCIENCE.pdf
11358
2014
eng
article
1
2015-05-21
--
--
Studentized continuous wavelet transform (t-CWT) in the analysis of individual ERPs: real and simulated EEG data
This study aimed at evaluating the performance of the Studentized Continuous Wavelet Transform (t-CWT) as a method for the extraction and assessment of event-related brain potentials (ERP) in data from a single subject. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of the t-CWT were assessed and compared to a variety of competing procedures using simulated EEG data at six low signal-to-noise ratios. Results show that the t-CWT combines high sensitivity and specificity with favorable PPV and NPV. Applying the t-CWT to authentic EEG data obtained from 14 healthy participants confirmed its high sensitivity. The t-CWT may thus be well suited for the assessment of weak ERPs in single-subject settings.
10.3389/fnins.2014.00279
urn:nbn:de:bvb:20-opus-113581
Frontiers in Neuroscience 8:279 (2014). 10.3389/fnins.2014.00279
247919
287320
Ruben G. L. Real
Boris Kotchoubey
Andrea Kübler
eng
uncontrolled
electroencephalogram
eng
uncontrolled
wavelet
eng
uncontrolled
EEG
eng
uncontrolled
t-CWT
eng
uncontrolled
significance
eng
uncontrolled
detection
eng
uncontrolled
ERP
Psychologie
open_access
Institut für Psychologie
OpenAIRE
Förderzeitraum 2014
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/11358/141_Real_FrontiersNeuroscience.pdf