16818
2018
eng
1
44
article
1
2018-09-12
--
--
Visual and Semiquantitative Accuracy in Clinical Baseline 123I-Ioflupane SPECT/CT Imaging
PURPOSE:
We aimed to (a) elucidate the concordance of visual assessment of an initial I-ioflupane scan by a human interpreter with comparison to results using a fully automatic semiquantitative method and (b) to assess the accuracy compared to follow-up (f/u) diagnosis established by movement disorder specialists.
METHODS:
An initial I-ioflupane scan was performed in 382 patients with clinically uncertain Parkinsonian syndrome. An experienced reader performed a visual evaluation of all scans independently. The findings of the visual read were compared with semiquantitative evaluation. In addition, available f/u clinical diagnosis (serving as a reference standard) was compared with results of the human read and the software.
RESULTS:
When comparing the semiquantitative method with the visual assessment, discordance could be found in 25 (6.5%) of 382 of the cases for the experienced reader (ĸ = 0.868). The human observer indicated region of interest misalignment as the main reason for discordance. With neurology f/u serving as reference, the results of the reader revealed a slightly higher accuracy rate (87.7%, ĸ = 0.75) compared to semiquantification (86.2%, ĸ = 0.719, P < 0.001, respectively). No significant difference in the diagnostic performance of the visual read versus software-based assessment was found.
CONCLUSIONS:
In comparison with a fully automatic semiquantitative method in I-ioflupane interpretation, human assessment obtained an almost perfect agreement rate. However, compared to clinical established diagnosis serving as a reference, visual read seemed to be slightly more accurate as a solely software-based quantitative assessment.
Clinical Nuclear Medicine
1536-0229
urn:nbn:de:bvb:20-opus-168181
Clinical Nuclear Medicine 2019, 44, 1, p 1–3 doi: 10.1097/RLU.0000000000002333
701983
false
true
CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International
Rudolf A. Werner
Charles Marcus
Sara Sheikhbahaei
Lilja B. Solnes
Jeffrey P. Leal
Yong Du
Steven P. Rowe
Takahiro Higuchi
Andreas K. Buck
Constantin Lapa
Mehrbod S. Javadi
deu
uncontrolled
Single-Photon-Emissions-Computertomographie
deu
swd
SPECT
eng
uncontrolled
Parkinson’s disease
eng
uncontrolled
Parkinsonism
eng
uncontrolled
DaTscan
eng
uncontrolled
123I-Ioflupane
eng
uncontrolled
SPECT
eng
uncontrolled
SPECT/CT
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16818/Werner_Visual_and_Semiquantitative_Accuracy_Clinical_Nuclear_Medicine_2019.pdf
16221
2018
eng
1646
Supplement No 1
59
conferenceobject
1
2018-05-27
--
--
The Impact of Ageing on Dopamine Transporter Imaging
No abstract available.
Journal of Nuclear Medicine
0161-5505
urn:nbn:de:bvb:20-opus-162213
http://jnm.snmjournals.org/content/59/supplement_1/1646.abstract
This research was originally published in JNM. Rudolf A. Werner, Charles Marcus, Sara Sheikhbahaei, Takahiro Higuchi, Lilja B. Solnes, Steven P. Rowe, Andreas K. Buck, Constantin Lapa, Mehrbod S. Javadi. The Impact of Ageing on Dopamine Transporter Imaging. J Nucl Med. May 1, 2018; vol. 59 no. supplement 1:1646. © SNMMI.
Johns Hopkins School of Medicine
701983
Journal of Nuclear Medicine May 1, 2018 vol. 59 no. supplement 1 1646
Deutsches Urheberrecht
Rudolf A. Werner
Charles Marcus
Sara Sheikhbahaei
Takahiro Higuchi
Lilja B. Solnes
Steven P. Rowe
Andreas K. Buck
Constantin Lapa
Mehrbod S. Javadi
deu
swd
Parkinson-Krankheit
eng
uncontrolled
Parkinson
eng
uncontrolled
Parkinson Disease
eng
uncontrolled
DaTscan
eng
uncontrolled
Ioflupane
eng
uncontrolled
SPECT
eng
uncontrolled
molecular imaging
eng
uncontrolled
ageing
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16221/Werner_Rudolf_Ageing_DaTscan_JNM_accepted_version.pdf
14920
2015
eng
545-558
6
5
article
1
2017-05-24
--
--
Radionuclide imaging of neurohormonal system of the heart
Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included.
Theranostics
10.7150/thno.10900
urn:nbn:de:bvb:20-opus-149205
Theranostics 5(6), 545-558 (2015). DOI: 10.7150/thno.10900
CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International
Xinyu Chen
Rudolf A. Werner
Mehrbod S. Javadi
Yoshifumi Maya
Michael Decker
Constantin Lapa
Ken Herrmann
Takahiro Higuchi
eng
uncontrolled
SPECT
eng
uncontrolled
radiotracer
eng
uncontrolled
heart failure
eng
uncontrolled
cardiac neurohormonal system
eng
uncontrolled
nuclear cardiology
eng
uncontrolled
PET
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für Pharmazie und Lebensmittelchemie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14920/065_Chen_Theranostics.pdf
23036
2020
eng
7
article
1
2021-03-10
--
--
Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging
Background
Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT\(^+\)).
Methods
The new U-SPECT5-E with two stationary detectors was used for acquiring data with \(^{99m}\)Tc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT\(^+\) for comparison.
Results
Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT\(^+\). In the visually analysed sections of the reconstructed mini Derenzo phantoms, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT\(^+\)) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60 to 1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR.
Conclusions
While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.
EJNMMI Physics
10.1186/s40658-020-00335-6
urn:nbn:de:bvb:20-opus-230361
publish
EJNMMI Physics (2020) 7:64. https://doi.org/10.1186/s40658-020-00335-6
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Jan V. Hoffmann
Jan P. Janssen
Takayuki Kanno
Takayuki Shibutani
Masahisa Onoguchi
Constantin Lapa
Jan-Peter Grunz
Andreas K. Buck
Takahiro Higuchi
eng
uncontrolled
small-animal imaging
eng
uncontrolled
SPECT
eng
uncontrolled
mouse
eng
uncontrolled
ollimator
eng
uncontrolled
post-reconstruction filtering
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik)
Deutsches Zentrum für Herzinsuffizienz (DZHI)
Förderzeitraum 2020
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/23036/s40658-020-00335-6.pdf
16913
2018
eng
article
1
2018-10-12
--
--
Moving into the Next Era of PET Myocardial Perfusion Imaging - Introduction of Novel \(^{18}\)F-labeled Tracers
The heart failure (HF) epidemic continues to rise with coronary artery disease (CAD) as one of its main causes. Novel concepts for risk stratification to guide the referring cardiologist towards revascularization procedures are of significant value. Myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) agents has demonstrated high accuracy for the detection of clinically relevant stenoses. With positron emission tomography (PET) becoming more widely available, mainly due to its diagnostic performance in oncology, perfusion imaging with that modality is more practical than in the past and overcomes existing limitations of SPECT MPI. Advantages of PET include more reliable quantification of absolute myocardial blood flow, the routine use of computed tomography for attenuation correction, a higher spatiotemporal resolution and a higher count sensitivity. Current PET radiotracers such as rubidium-82 (half-life, 76 sec), oxygen-15 water (2 min) or nitrogen-13 ammonia (10 min) are labeled with radionuclides with very short half-lives, necessitating that stress imaging is performed under pharmacological vasodilator stress instead of exercise testing. However, with the introduction of novel 18F-labeled MPI PET radiotracers (half-life, 110 min), the intrinsic advantages of PET can be combined with exercise testing. Additional advantages of those radiotracers include, but are not limited to: potentially improved cost-effectiveness due to the use of pre-existing delivery systems and superior imaging qualities, mainly due to the shortest positron range among available PET MPI probes. In the present review, widely used PET MPI radiotracers will be reviewed and potential novel 18F-labeled perfusion radiotracers will be discussed.
The International Journal of Cardiovascular Imaging
1569-5794
10.1007/s10554-018-1469-z
urn:nbn:de:bvb:20-opus-169134
Johns Hopkins University, Baltimore, MD, U.S.
International Journal of Cardiovascular Imaging (2019) 35: 569. https://doi.org/10.1007/s10554-018-1469-z
701983
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Rudolf A. Werner
Xinyu Chen
Steven P. Rowe
Constantin Lapa
Mehrbod S. Javadi
Takahiro Higuchi
eng
uncontrolled
heart failure with mid-range ejection fraction
deu
swd
Positronenemissionstomografie
eng
uncontrolled
coronary artery disease
eng
uncontrolled
precision medicine
eng
uncontrolled
positron emission tomography
eng
uncontrolled
PET
eng
uncontrolled
SPECT
eng
uncontrolled
myocardial perfusion imaging
eng
uncontrolled
MPI
eng
uncontrolled
18F-flurpiridaz
eng
uncontrolled
18FFBnTP
eng
uncontrolled
HFmrEF
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16913/Werner2018_IJCI_PETMyocardialPerfusionImaging.pdf
16220
2018
eng
626
Supplement No. 1
59
conferenceobject
1
2018-05-27
--
--
Diagnostic Accuracy of Visual Assessment of an Initial DaT-Scan in Comparison to a Fully Automatic Semiquantitative Method
No abstract available.
Journal of Nuclear Medicine
0161-5505
http://jnm.snmjournals.org/content/59/supplement_1/626.abstract
urn:nbn:de:bvb:20-opus-162208
This research was originally published in JNM. Rudolf A. Werner, Charles Marcus, Sara Sheikhbahaei, Takahiro Higuchi, Lilja B. Solnes, Steven P. Rowe, Andreas K. Buck, Constantin Lapa, Mehrbod S. Javadi. Diagnostic Accuracy of Visual Assessment of an Initial DaT-Scan in Comparison to a Fully Automatic Semiquantitative Method. J Nucl Med. May 1, 2018; vol. 59 no. supplement 1:626. © SNMMI.
Johns Hopkins School of Medicine
701983
Journal of Nuclear Medicine May 1, 2018 vol. 59 no. supplement 1 626
Deutsches Urheberrecht
Rudolf A. Werner
Charles Marcus
Sara Sheikhbahaei
Takahiro Higuchi
Lilja B. Solnes
Steven P. Rowe
Andreas K. Buck
Constantin Lapa
Mehrbod S. Javadi
deu
swd
Parkinson-Krankheit
eng
uncontrolled
SPECT
eng
uncontrolled
Parkinson
eng
uncontrolled
Parkinson Disease
eng
uncontrolled
DaTscan
eng
uncontrolled
Ioflupane
eng
uncontrolled
molecular imaging
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16220/Werner_Rudolf_Accuracy_DaT-Scan_JNM_accepted_version.pdf