19662
2012
eng
224
227
3
224
article
1
--
2012-06-05
--
Adjuvant treatment of recalcitrant Bullous pemphigoid with immunoadsorption
Elimination of pathogenic autoantibodies by immunoadsorption (IA) has been described as an effective adjuvant treatment in severe bullous autoimmune diseases, especially in pemphigus. There is much less experience in the treatment of bullous pemphigoid (BP). BP was diagnosed in a 62-year-old Caucasian woman presenting a pruritic rash with multiple tense blisters. Standard treatments with topical and oral corticosteroids, steroid-sparing agents including dapsone, azathioprine, mycophenolate mofetil (MMF) and intravenous immunoglobulins were ineffective or had to be discontinued due to adverse events. An immediate clinical response could be achieved by two treatment cycles of adjuvant protein A immunoadsorption (PA-IA) in addition to continued treatment with MMF (2 g/day) and prednisolone (1 mg/kg/day). Tolerance was excellent. Clinical improvement remained stable after discontinuation of IA and went along with sustained reduction of circulating autoantibodies. Our data demonstrate that PA-IA might be a safe and effective adjuvant treatment in severe and recalcitrant BP.
Dermatology
1018-8665
1421-9832
10.1159/000339071
22678083
urn:nbn:de:bvb:20-opus-196620
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:19:23+00:00
attachment; filename=deposit.zip
92c982b2f0ff2d913139d8796181b472
Dermatology (2012) 224:3, 224-227. https://doi.org/10.1159/000339071
true
true
Deutsches Urheberrecht
P.A. Müller
E.B. Bröcker
E. Klinker
J. Stoevesandt
S. Benoit
eng
uncontrolled
Bullous pemphigoid
eng
uncontrolled
Immunoadsorption
eng
uncontrolled
Immunoapheresis
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Institut für Klinische Transfusionsmedizin und Hämotherapie
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19662/DRM339071.pdf
6878
1990
eng
article
1
2013-11-21
--
--
The polyphase thermal history of the Erbendorf-Vohenstrauß (ZEV) and the Erbendorf Greenschist (EGZ) zones of NE Bavaria in the light of Ar-Ar spectra
no abstract available
urn:nbn:de:bvb:20-opus-81862
8186
In: European journal of mineralogy (1990), 2, Beih. 1, p. 231
Deutsches Urheberrecht
Ulrich Schüssler
M. Okrusch
M. Patzak
P. Müller
H. Kreuzer
deu
swd
Erbendorf
deu
swd
Vohenstrauß
Geowissenschaften
open_access
Institut für Geographie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6878/Schuessler08.pdf