12134
2014
eng
13-32
96
article
1
2015-10-28
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Treatment of invasive fungal infections in cancer patients—updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
Invasive fungal infections are a main cause of morbidity and mortality in cancer patients undergoing intensive chemotherapy regimens. Early antifungal treatment is mandatory to improve survival. Today, a number of effective and better-tolerated but more expensive antifungal agents compared to the former gold standard amphotericin B deoxycholate are available. Clinical decision-making must consider results from numerous studies and published guidelines, as well as licensing status and cost pressure. New developments in antifungal prophylaxis improving survival rates result in a continuous need for actualization. The treatment options for invasive Candida infections include fluconazole, voriconazole, and amphotericin B and its lipid formulations, as well as echinocandins. Voriconazole, amphotericin B, amphotericin B lipid formulations, caspofungin, itraconazole, and posaconazole are available for the treatment of invasive aspergillosis. Additional procedures, such as surgical interventions, immunoregulatory therapy, and granulocyte transfusions, have to be considered. The Infectious Diseases Working Party of the German Society of Hematology and Oncology here presents its 2008 recommendations discussing the dos and do-nots, as well as the problems and possible solutions, of evidence criteria selection.
Annals of Hematology
10.1007/s00277-013-1867-1
24026426
urn:nbn:de:bvb:20-opus-121340
Annals of Hematology (2014) 93:13–32 DOI 10.1007/s00277-013-1867-1
Sabine Mousset
Dieter Buchheidt
Werner Heinz
Markus Ruhnke
Oliver A. Cornely
Gerlinde Egerer
William Krüger
Hartmut Link
Silke Neumann
Helmut Ostermann
Jens Panse
Olaf Penack
Christina Rieger
Martin Schmidt-Hieber
Gerda Silling
Thomas Südhoff
Andrew J. Ullmann
Hans-Heinrich Wolf
Georg Maschmeyer
Angelika Böhme
eng
uncontrolled
cancer
eng
uncontrolled
invasive fungal infections
eng
uncontrolled
antifungals
eng
uncontrolled
mycoses
eng
uncontrolled
hematologic malignancies
eng
uncontrolled
aspergillosis
eng
uncontrolled
antifungal agents
eng
uncontrolled
invasive candidiasis
Medizin und Gesundheit
open_access
Medizinische Klinik und Poliklinik II
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12134/044_Mousset_Annals_of_Hematology.pdf
12932
2013
eng
ID 102934
article
1
2016-03-10
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Immunological Aspects of Candida and Aspergillus Systemic Fungal Infections
Patients with allogeneic stem cell transplantation (SCT) have a high risk of invasive fungal infections (IFIs) even after neutrophil regeneration. Immunological aspects might play a very important role in the IFI development in these patients. Some data are available supporting the identification of high-risk patients with IFI for example patients receiving stem cells fromTLR4 haplotype S4 positive donors. Key defense mechanisms against IFI include the activation of neutrophils, the phagocytosis of germinating conidia by dendritic cells, and the fight of the cells of the innate immunity such as monocytes and natural killer cells against germlings and hyphae. Furthermore, immunosuppressive drugs interact with immune effector cells influencing the specific fungal immune defense and antimycotic drugs might interact with immune response. Based on the current knowledge on immunological mechanism in Aspergillus fumigatus, the first approaches of an immunotherapy using human T cells are in development. This might be an option for the future of aspergillosis patients having a poor prognosis with conventional treatment.
Interdisciplinary Perspectives on Infectious Diseases
10.1155/2013/102934
urn:nbn:de:bvb:20-opus-129327
Interdisciplinary Perspectives on Infectious Diseases, Volume 2013, Article ID 102934, 7 pages, http://dx.doi.org/10.1155/2013/102934
Christoph Mueller-Loebnitz
Helmut Ostermann
Anke Franzke
Juergen Loeffler
Lutz Uharek
Max Topp
Hermann Einsele
eng
uncontrolled
Infectious Diseases
Medizin und Gesundheit
open_access
Medizinische Klinik und Poliklinik II
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12932/049_Mueller-Loebnitz_Ostermann.pdf