12993
2012
eng
573-579
4
224
article
1
2016-03-14
--
--
A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity
Rationale
The endocannabinoid (eCB) system is implicated in several psychiatric disorders. Investigating emotional–motivational dysfunctions as underlying mechanisms, a study in humans revealed that in the C385A polymorphism of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the eCB anandamide (AEA), A carriers, who are characterized by increased signaling of AEA as compared to C/C carriers, exhibited reduced brain reactivity towards unpleasant faces and enhanced reactivity towards reward. However, the association of eCB system with emotional–motivational reactivity is complex and bidirectional due to upcoming compensatory processes.
Objectives
Therefore, we further investigated the relationship of the FAAH polymorphism and emotional–motivational reactivity in humans.
Methods
We assessed the affect-modulated startle, and ratings of valence and arousal in response to higher arousing pleasant, neutral, and unpleasant pictures in 67 FAAH C385A C/C carriers and 45 A carriers.
Results
Contrarily to the previous functional MRI study, A carriers compared to C/C carriers exhibited an increased startle potentiation and therefore emotional responsiveness towards unpleasant picture stimuli and reduced startle inhibition indicating reduced emotional reactivity in response to pleasant pictures, while both groups did not differ in ratings of arousal and valence.
Conclusions
Our findings emphasize the bidirectionality and thorough examination of the eCB system’s impact on emotional reactivity as a central endophenotype underlying various psychiatric disorders.
Psychopharmacology
10.1007/s00213-012-2785-y
urn:nbn:de:bvb:20-opus-129936
Psychopharmacology (2012) 224:573–579. DOI 10.1007/s00213-012-2785-y
Annette Conzelmann
Andreas Reif
Christian Jacob
Peter Weyers
Klaus-Peter Lesch
Beat Lutz
Paul Pauli
eng
uncontrolled
startle reflex
eng
uncontrolled
FAAH
eng
uncontrolled
genetics
eng
uncontrolled
endocannabinoid
eng
uncontrolled
emotion
Psychologie
open_access
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Institut für Pädagogik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12993/Conzelmann_10.1007-00213-012-2785-y.pdf
12684
2012
eng
573-579
4
224
article
1
2016-02-10
--
--
A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity
RATIONALE:
The endocannabinoid (eCB) system is implicated in several psychiatric disorders. Investigating emotional-motivational dysfunctions as underlying mechanisms, a study in humans revealed that in the C385A polymorphism of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the eCB anandamide (AEA), A carriers, who are characterized by increased signaling of AEA as compared to C/C carriers, exhibited reduced brain reactivity towards unpleasant faces and enhanced reactivity towards reward. However, the association of eCB system with emotional-motivational reactivity is complex and bidirectional due to upcoming compensatory processes.
OBJECTIVES:
Therefore, we further investigated the relationship of the FAAH polymorphism and emotional-motivational reactivity in humans.
METHODS:
We assessed the affect-modulated startle, and ratings of valence and arousal in response to higher arousing pleasant, neutral, and unpleasant pictures in 67 FAAH C385A C/C carriers and 45 A carriers.
RESULTS:
Contrarily to the previous functional MRI study, A carriers compared to C/C carriers exhibited an increased startle potentiation and therefore emotional responsiveness towards unpleasant picture stimuli and reduced startle inhibition indicating reduced emotional reactivity in response to pleasant pictures, while both groups did not differ in ratings of arousal and valence.
CONCLUSIONS:
Our findings emphasize the bidirectionality and thorough examination of the eCB system's impact on emotional reactivity as a central endophenotype underlying various psychiatric disorders.
Psychopharmacology
10.1007/s00213-012-2785-y
urn:nbn:de:bvb:20-opus-126845
Psychopharmacology (2012) 224:573–579 DOI 10.1007/s00213-012-2785-y
Annette Conzelmann
Andreas Reif
Christian Jacob
Peter Weyers
Klaus-Peter Lesch
Beat Lutz
Paul Pauli
eng
uncontrolled
startle reflex
eng
uncontrolled
endocannabinoid
eng
uncontrolled
FAAH
eng
uncontrolled
genetics
eng
uncontrolled
emotion
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Institut für Psychologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12684/Conzelmann_2Fs00213-012-2785-y.pdf