4544
2010
deu
conferenceobject
6. Würzburger Wirtschaftssymposium 2010
Contact & Cooperation Würzburg e.V. , i.a.c. Würzburg e.V.
1
2010-12-22
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Chef, lass uns mal Kultur machen! Festschrift zum 6. Würzburger Wirtschaftssymposium
Am Montag, den 29. November 2010 fand das 6. Würzburger Wirtschaftssymposium unter dem Leitmotiv "Chef, lass uns mal Kultur machen!" statt. Die gemeinnützige Veranstaltung versteht sich seit jeher als Ort der Begegnung und des gemeinsamen Gedankenaustauschs, Studenten und Mitarbeiter aller Fachbereiche nahmen ebenso teil wie interessierte Bürger außerhalb der Würzburger Hochschulen. Die Festschrift enthält Interviews mit sowie Gastbeiträge von Referenten des 6. Würzburger Wirtschaftssymposiums. Darüber hinaus greifen Gastbeiträge von Experten aus Wissenschaft, Wirtschaft, Politik und Gesellschaft weitere Facetten auf und stellen das Thema damit auf eine breitere Grundlage.
978-3-923959-66-2
urn:nbn:de:bvb:20-opus-53329
5332
Schwaneck, Stefan (Herausgeber)
Stefan Schwaneck
Christopher Welge
Ann-Kathrin Bopp
Sarah Faulhaber
Susanne Hampel
Maike Pfletschinger
Lisa Nebelung
Berit Hamme
Birger Priddat
Thomas Salmen
Georg Rosenthal
Bernd Neumann
Steffen Deeg
Frank Buytendijk
Thomas Gonzalez
Gloria Träger
Benjamin Mayer
Christoph Mohamad
Heinz Reinders
Bernhard Bohmeier
deu
swd
Festschrift
deu
swd
Unternehmenskultur
deu
swd
Kulturwirtschaft
deu
swd
Geistiges Eigentum
deu
swd
Jugendkultur
deu
uncontrolled
Wirtschaft
deu
uncontrolled
Kultur
deu
uncontrolled
Unternehmenskultur
deu
uncontrolled
Kreativ- und Kulturwirtschaft
deu
uncontrolled
Mainfranken Theater
eng
uncontrolled
business culture
eng
uncontrolled
economics
eng
uncontrolled
intellectual property
Wirtschaft
open_access
Universität Würzburg
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/4544/Wirtschaftssymposium_2010.pdf
31359
2023
eng
8
24
article
1
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2023-04-13
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Investigation of the compatibility between warheads and peptidomimetic sequences of protease inhibitors — a comprehensive reactivity and selectivity study
Covalent peptidomimetic protease inhibitors have gained a lot of attention in drug development in recent years. They are designed to covalently bind the catalytically active amino acids through electrophilic groups called warheads. Covalent inhibition has an advantage in terms of pharmacodynamic properties but can also bear toxicity risks due to non-selective off-target protein binding. Therefore, the right combination of a reactive warhead with a well-suited peptidomimetic sequence is of great importance. Herein, the selectivities of well-known warheads combined with peptidomimetic sequences suited for five different proteases were investigated, highlighting the impact of both structure parts (warhead and peptidomimetic sequence) for affinity and selectivity. Molecular docking gave insights into the predicted binding modes of the inhibitors inside the binding pockets of the different enzymes. Moreover, the warheads were investigated by NMR and LC-MS reactivity assays against serine/threonine and cysteine nucleophile models, as well as by quantum mechanics simulations.
International Journal of Molecular Sciences
1422-0067
10.3390/ijms24087226
urn:nbn:de:bvb:20-opus-313596
2023-05-05T10:53:22+00:00
sword
swordwue
attachment; filename=deposit.zip
97130647bd10a2d0c06acd6efed8caba
International Journal of Molecular Sciences (2023) 24:8, 7226. https://doi.org/10.3390/ijms24087226
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Patrick Müller
Mergim Meta
Jan Laurenz Meidner
Marvin Schwickert
Jessica Meyr
Kevin Schwickert
Christian Kersten
Collin Zimmer
Stefan Josef Hammerschmidt
Ariane Frey
Albin Lahu
Sergio de la Hoz-Rodríguez
Laura Agost-Beltrán
Santiago Rodríguez
Kira Diemer
Wilhelm Neumann
Florenci V. Gonzàlez
Bernd Engels
Tanja Schirmeister
eng
uncontrolled
covalent inhibitors
eng
uncontrolled
in vitro study
eng
uncontrolled
protease inhibitors
eng
uncontrolled
peptidomimetic sequence
eng
uncontrolled
warhead
eng
uncontrolled
reactivity and selectivity study
Chemie und zugeordnete Wissenschaften
open_access
Institut für Physikalische und Theoretische Chemie
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/31359/ijms-24-07226-v3.pdf
30411
2023
eng
4
13
article
1
--
2023-02-16
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Performance of T-Track\(^®\) TB, a novel dual marker RT-qPCR-based whole-blood test for improved detection of active tuberculosis
Tuberculosis (TB) is one of the leading causes of death by an infectious disease. It remains a major health burden worldwide, in part due to misdiagnosis. Therefore, improved diagnostic tests allowing the faster and more reliable diagnosis of patients with active TB are urgently needed. This prospective study examined the performance of the new molecular whole-blood test T-Track\(^®\) TB, which relies on the combined evaluation of IFNG and CXCL10 mRNA levels, and compared it to that of the QuantiFERON\(^®\)-TB Gold Plus (QFT-Plus) enzyme-linked immunosorbent assay (ELISA). Diagnostic accuracy and agreement analyses were conducted on the whole blood of 181 active TB patients and 163 non-TB controls. T-Track\(^®\) TB presented sensitivity of 94.9% and specificity of 93.8% for the detection of active TB vs. non-TB controls. In comparison, the QFT-Plus ELISA showed sensitivity of 84.3%. The sensitivity of T-Track\(^®\) TB was significantly higher (p < 0.001) than that of QFT-Plus. The overall agreement of T-Track\(^®\) TB with QFT-Plus to diagnose active TB was 87.9%. Out of 21 samples with discordant results, 19 were correctly classified by T-Track\(^®\) TB while misclassified by QFT-Plus (T-Track\(^®\) TB-positive/QFT-Plus-negative), and two samples were misclassified by T-Track\(^®\) TB while correctly classified by QFT-Plus (T-Track\(^®\) TB-negative/QFT-Plus-positive). Our results demonstrate the excellent performance of the T-Track\(^®\) TB molecular assay and its suitability to accurately detect TB infection and discriminate active TB patients from non-infected controls.
Diagnostics
2075-4418
10.3390/diagnostics13040758
urn:nbn:de:bvb:20-opus-304113
2023-03-14T05:54:11+00:00
sword
swordwue
attachment; filename=deposit.zip
899b1a612d1bf1e9bddb7300821fc6ef
Diagnostics (2023) 13:4, 758. https://doi.org/10.3390/diagnostics13040758
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Johannes P. Meier
Selina Möbus
Florian Heigl
Alexandra Asbach-Nitzsche
Hans Helmut Niller
Annelie Plentz
Korkut Avsar
Marion Heiß-Neumann
Bernhard Schaaf
Uwe Cassens
Bernd Seese
Daniel Teschner
Sabin Handzhiev
Uwe Graf
Christoph Lübbert
Monika Steinmaurer
Konstantina Kontogianni
Christoph Berg
Andreas Maieron
Stefan H. Blaas
Ralf Wagner
Ludwig Deml
Sascha Barabas
eng
uncontrolled
tuberculosis
eng
uncontrolled
TB
eng
uncontrolled
active TB
eng
uncontrolled
infection detection
eng
uncontrolled
T-Track\(^®\) TB
eng
uncontrolled
QuantiFERON\(^®\)-TB Gold Plus
eng
uncontrolled
mRNA
eng
uncontrolled
RT-qPCR
eng
uncontrolled
CXCL10
eng
uncontrolled
IFNG
Medizin und Gesundheit
open_access
Medizinische Klinik und Poliklinik II
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/30411/diagnostics-13-00758-v2.pdf