17194
2017
eng
19
article
1
2018-11-15
--
--
Nanoscale patterning, macroscopic reconstruction, and enhanced surface stress by organic adsorption on vicinal surfaces
Self-organization is a promising method within the framework of bottom-up architectures to generate nanostructures in an efficient way. The present work demonstrates that self- organization on the length scale of a few to several tens of nanometers can be achieved by a proper combination of a large (organic) molecule and a vicinal metal surface if the local bonding of the molecule on steps is significantly stronger than that on low-index surfaces. In this case thermal annealing may lead to large mass transport of the subjacent substrate atoms such that nanometer-wide and micrometer-long molecular stripes or other patterns are being formed on high-index planes. The formation of these patterns can be controlled by the initial surface orientation and adsorbate coverage. The patterns arrange self-organized in regular arrays by repulsive mechanical interactions over long distances accompanied by a significant enhancement of surface stress. We demonstrate this effect using the planar organic molecule PTCDA as adsorbate and Ag(10 8 7) and Ag(775)surfaces as substrate. The patterns are directly observed by STM, the formation of vicinal surfaces is monitored by highresolution electron diffraction, the microscopic surface morphology changes are followed by spectromicroscopy, and the macroscopic changes of surface stress are measured by a cantilever bending method. The in situ combination of these complementary techniques provides compelling evidence for elastic interaction and a significant stress contribution to long-range order and nanopattern formation.
New Journal of Physics
10.1088/1367-2630/aa55b8
urn:nbn:de:bvb:20-opus-171947
New Journal of Physics (2017) 19:013019; https://doi.org/10.1088/1367-2630/aa55b8
true
true
Florian Pollinger
Stefan Schmitt
Dirk Sander
Zhen Tian
Jürgen Kirschner
Pavo Vrdoljak
Christoph Stadler
Florian Maier
Helder Marchetto
Thomas Schmidt
Achim Schöll
Eberhard Umbach
eng
uncontrolled
physics
eng
uncontrolled
patterning
eng
uncontrolled
reconstruction
eng
uncontrolled
surface stress
eng
uncontrolled
STM
eng
uncontrolled
SPA-LEED
eng
uncontrolled
vicinal surfaces
eng
uncontrolled
adsoption
Physik
open_access
Physikalisches Institut
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/17194/Pollinger_2017_New_J._Phys._19_013019.pdf
6403
2011
eng
article
1
2013-02-05
--
--
Differential Effects of Prenatal Stress in 5-Htt Deficient Mice: Towards Molecular Mechanisms of Gene x Environment Interactions
Prenatal stress (PS) has been shown to influence the development of the fetal brain and to increase the risk for the development of psychiatric disorders in later life. Furthermore, the variation of human serotonin transporter (5-HTT, SLC6A4) gene was suggested to exert a modulating effect on the association between early life stress and the risk for depression. In the present study, we used a 5-Htt6PS paradigm to investigate whether the effects of PS are dependent on the 5-Htt genotype. For this purpose, the effects of PS on cognition, anxiety- and depression-related behavior were examined using a maternal restraint stress paradigm of PS in C57BL6 wild-type (WT) and heterozygous 5-Htt deficient (5-Htt +/2) mice. Additionally, in female offspring, a genome-wide hippocampal gene expression profiling was performed using the Affymetrix GeneChipH Mouse Genome 430 2.0 Array. 5-Htt +/2 offspring showed enhanced memory performance and signs of reduced anxiety as compared to WT offspring. In contrast, exposure of 5-Htt +/2 mice to PS was associated with increased depressive-like behavior, an effect that tended to be more pronounced in female offspring. Further, 5-Htt genotype, PS and their interaction differentially affected the expression of numerous genes and related pathways within the female hippocampus. Specifically, MAPK and neurotrophin signaling were regulated by both the 5-Htt +/2 genotype and PS exposure, whereas cytokine and Wnt signaling were affected in a 5-Htt genotype6PS manner, indicating a gene6environment interaction at the molecular level. In conclusion, our data suggest that although the 5-Htt +/2 genotype shows clear adaptive capacity, 5-Htt +/2 mice –particularly females– at the same time appear to be more vulnerable to developmental stress exposure when compared to WT offspring. Moreover, hippocampal gene expression profiles suggest that distinct molecular mechanisms mediate the behavioral effects of the 5-Htt genotype, PS exposure, and their interaction.
urn:nbn:de:bvb:20-opus-75795
7579
In: PLoS ONE (2011) 6(8): e22715. doi:10.1371/journal.pone.0022715
Daniel Van den Hove
Sissi Brigitte Jakob
Karla-Gerlinde Schraut
Gunter Kenis
Angelika Gertrud Schmitt
Susanne Kneitz
Claus-Jürgen Scholz
Valentina Wiescholleck
Gabriela Ortega
Jos Prickaerts
Harry Steinbusch
Klaus-Peter Lesch
deu
swd
Medizin
Medizin und Gesundheit
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6403/vandenHove_journal.pone.0022715.pdf
12259
2013
eng
32
10
article
1
2015-12-02
--
--
Crematoenones - a novel substance class exhibited by ants functions as appeasement signal
Background: Parasitic, commensalistic, and mutualistic guests in social insect colonies often circumvent their hosts' nestmate recognition system to be accepted. These tolerance strategies include chemical mimicry and chemical insignificance. While tolerance strategies have been studied intensively in social parasites, little is known about these mechanisms in non-parasitic interactions. Here, we describe a strategy used in a parabiotic association, i.e. two mutualistic ant species that regularly share a common nest although they have overlapping food niches. One of them, Crematogaster modiglianii, produces an array of cuticular compounds which represent a substance class undescribed in nature so far. They occur in high abundances, which suggests an important function in the ant's association with its partner Camponotus rufifemur.
Results: We elucidated the structure of one of the main compounds from cuticular extracts using gas chromatography, mass spectrometry, chemical derivatizations and nuclear magnetic resonance spectroscopy (NMR). The compound consists of two fused six-membered rings with two alkyl groups, one of which carries a keto functionality. To our knowledge, this is the first report on the identification of this substance class in nature. We suggest naming the compound crematoenone. In behavioural assays, crematoenones reduced interspecific aggression. Camponotus showed less aggression to allospecific cuticular hydrocarbons when combined with crematoenones. Thus, they function as appeasement substances. However, although the crematoenone composition was highly colony-specific, interspecific recognition was mediated by cuticular hydrocarbons, and not by crematoenones.
Conclusions: Crematenones enable Crematogaster to evade Camponotus aggression, and thus reduce potential costs from competition with Camponotus. Hence, they seem to be a key factor in the parabiosis, and help Crematogaster to gain a net benefit from the association and thus maintain a mutualistic association over evolutionary time. To our knowledge, putative appeasement substances have been reported only once so far, and never between non-parasitic species. Since most organisms associated with social insects need to overcome their nestmate recognition system, we hypothesize that appeasement substances might play an important role in the evolution and maintenance of other mutualistic associations as well, by allowing organisms to reduce costs from antagonistic behaviour of other species.
Frontiers in Zoology
10.1186/1742-9994-10-32
1742-9994
urn:nbn:de:bvb:20-opus-122595
Frontiers in Zoology 2013, 10:32. doi:10.1186/1742-9994-10-32
Florian Menzel
Nico Blüthgen
Till Tolasch
Jürgen Conrad
Uwe Beifuss
Till Beuerle
Thomas Schmitt
eng
uncontrolled
cuticular hydrocarbons
eng
uncontrolled
appeasement substance
eng
uncontrolled
bees
eng
uncontrolled
ecology
eng
uncontrolled
parasitism
eng
uncontrolled
alkyloctahydronaphthalene
eng
uncontrolled
usurpation
eng
uncontrolled
venom
eng
uncontrolled
pheromone
eng
uncontrolled
crematogaster
eng
uncontrolled
parabiotic ants
eng
uncontrolled
Dufours gland
eng
uncontrolled
polyergus rufescens
eng
uncontrolled
formicidae
eng
uncontrolled
interspecific aggression
eng
uncontrolled
nestmate recognition cues
eng
uncontrolled
parabiotic association
Arthropoden (Gliederfüßer)
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12259/035_Menzel_Frontiers_in_Zoology.pdf
13511
2011
eng
e22715
8
6
article
1
2016-06-17
--
--
Differential Effects of Prenatal Stress in 5-Htt Deficient Mice: Towards Molecular Mechanisms of Gene x Environment Interactions
Prenatal stress (PS) has been shown to influence the development of the fetal brain and to increase the risk for the development of psychiatric disorders in later life. Furthermore, the variation of human serotonin transporter (5-HTT, SLC6A4) gene was suggested to exert a modulating effect on the association between early life stress and the risk for depression. In the present study, we used a 5-HttxPS paradigm to investigate whether the effects of PS are dependent on the 5-Htt genotype. For this purpose, the effects of PS on cognition, anxiety-and depression-related behavior were examined using a maternal restraint stress paradigm of PS in C57BL6 wild-type (WT) and heterozygous 5-Htt deficient (5-Htt +/-) mice. Additionally, in female offspring, a genome-wide hippocampal gene expression profiling was performed using the Affymetrix GeneChip (R) Mouse Genome 430 2.0 Array. 5-Htt +/- offspring showed enhanced memory performance and signs of reduced anxiety as compared to WT offspring. In contrast, exposure of 5-Htt +/- mice to PS was associated with increased depressive-like behavior, an effect that tended to be more pronounced in female offspring. Further, 5-Htt genotype, PS and their interaction differentially affected the expression of numerous genes and related pathways within the female hippocampus. Specifically, MAPK and neurotrophin signaling were regulated by both the 5-Htt +/- genotype and PS exposure, whereas cytokine and Wnt signaling were affected in a 5-Htt genotypexPS manner, indicating a genexenvironment interaction at the molecular level. In conclusion, our data suggest that although the 5-Htt +/- genotype shows clear adaptive capacity, 5-Htt +/- mice -particularly females-at the same time appear to be more vulnerable to developmental stress exposure when compared to WT offspring. Moreover, hippocampal gene expression profiles suggest that distinct molecular mechanisms mediate the behavioral effects of the 5-Htt genotype, PS exposure, and their interaction.
PLoS ONE
10.1371/journal.pone.0022715
urn:nbn:de:bvb:20-opus-135111
PLoS ONE 6(8): e22715. doi:10.1371/journal.pone.0022715
false
true
Daniel Van den Hove
Sissi Brigitte Jakob
Karla-Gerlinde Schraut
Gunter Kenis
Angelika Gertrud Schmitt
Susanne Kneitz
Claus-Jürgen Scholz
Valentina Wiescholleck
Gabriela Ortega
Jos Prickaerts
Harry Steinbusch
Klaus-Peter Lesch
eng
uncontrolled
Serotonin transporter polymorphism
eng
uncontrolled
Acute tryptophan depletion
eng
uncontrolled
Anxiety-like behavior
eng
uncontrolled
Long-term depression
eng
uncontrolled
Knock-out mice
eng
uncontrolled
Major depression
eng
uncontrolled
Interferon-alpha
eng
uncontrolled
Physiological functions
eng
uncontrolled
Restraint stress
eng
uncontrolled
Bipolar disorder
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13511/036_vandenHove_PlosONE.PDF
19831
2020
eng
report
1
2020-01-20
--
--
Technical Report on Bridge-Local Guaranteed Latency with Strict Priority Scheduling
Bridge-local latency computation is often regarded with caution, as historic efforts with the Credit-Based Shaper (CBS) showed that CBS requires network wide information for tight bounds. Recently, new shaping mechanisms and timed gates were applied to achieve such guarantees nonetheless, but they require support for these new mechanisms in the forwarding devices.
This document presents a per-hop latency bound for individual streams in a class-based network that applies the IEEE 802.1Q strict priority transmission selection algorithm. It is based on self-pacing talkers and uses the accumulated latency fields during the reservation process to provide upper bounds with bridge-local information. The presented delay bound is proven mathematically and then evaluated with respect to its accuracy. It indicates the required information that must be provided for admission control, e.g., implemented by a resource reservation protocol such as IEEE 802.1Qdd. Further, it hints at potential improvements regarding new mechanisms and higher accuracy given more information.
urn:nbn:de:bvb:20-opus-198310
Siemens AG
false
true
CC BY-SA: Creative-Commons-Lizenz: Namensnennung, Weitergabe unter gleichen Bedingungen 4.0 International
Alexej Grigorjew
Florian Metzger
Tobias Hoßfeld
Johannes Specht
Franz-Josef Götz
Jürgen Schmitt
Feng Chen
deu
swd
Echtzeit
deu
swd
Rechnernetz
deu
swd
Latenz
deu
swd
Ethernet
eng
uncontrolled
Latency Bound
eng
uncontrolled
Formal analysis
Informatik, Informationswissenschaft, allgemeine Werke
GENERAL
open_access
Institut für Informatik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19831/Grigorjew_Guaranteed_Latency_Technical_Report.pdf
20582
2020
eng
8
report
1
2020-06-10
--
--
Asynchronous Traffic Shaping with Jitter Control
Asynchronous Traffic Shaping enabled bounded latency with low complexity for time sensitive networking without the need for time synchronization. However, its main focus is the guaranteed maximum delay. Jitter-sensitive applications may still be forced towards synchronization. This work proposes traffic damping to reduce end-to-end delay jitter. It discusses its application and shows that both the prerequisites and the guaranteed delay of traffic damping and ATS are very similar. Finally, it presents a brief evaluation of delay jitter in an example topology by means of a simulation and worst case estimation.
10.25972/OPUS-20582
urn:nbn:de:bvb:20-opus-205824
Siemens AG
University of Duisburg-Essen
false
true
CC BY-SA: Creative-Commons-Lizenz: Namensnennung, Weitergabe unter gleichen Bedingungen 4.0 International
Alexej Grigorjew
Florian Metzger
Tobias Hoßfeld
Johannes Specht
Franz-Josef Götz
Feng Chen
Jürgen Schmitt
deu
swd
Echtzeit
deu
swd
Rechnernetz
deu
swd
Latenz
deu
swd
Ethernet
eng
uncontrolled
TSN
eng
uncontrolled
jitter
eng
uncontrolled
traffic damping
Informatik, Informationswissenschaft, allgemeine Werke
open_access
Institut für Informatik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/20582/atsplus.pdf
16538
2016
eng
320
7
article
1
2018-07-23
--
--
Genome-Wide Expression Profiling Reveals S100B as Biomarker for Invasive Aspergillosis
Invasive aspergillosis (IA) is a devastating opportunistic infection and its treatment constitutes a considerable burden for the health care system. Immunocompromised patients are at an increased risk for IA, which is mainly caused by the species Aspergillus fumigatus. An early and reliable diagnosis is required to initiate the appropriate antifungal therapy. However, diagnostic sensitivity and accuracy still needs to be improved, which can be achieved at least partly by the definition of new biomarkers. Besides the direct detection of the pathogen by the current diagnostic methods, the analysis of the host response is a promising strategy toward this aim. Following this approach, we sought to identify new biomarkers for IA. For this purpose, we analyzed gene expression profiles of hematological patients and compared profiles of patients suffering from IA with non-IA patients. Based on microarray data, we applied a comprehensive feature selection using a random forest classifier. We identified the transcript coding for the S100 calcium-binding protein B (S100B) as a potential new biomarker for the diagnosis of IA. Considering the expression of this gene, we were able to classify samples from patients with IA with 82.3% sensitivity and 74.6% specificity. Moreover, we validated the expression of S100B in a real-time reverse transcription polymerase chain reaction (RT-PCR) assay and we also found a down-regulation of S100B in A. fumigatus stimulated DCs. An influence on the IL1B and CXCL1 downstream levels was demonstrated by this S100B knockdown. In conclusion, this study covers an effective feature selection revealing a key regulator of the human immune response during IA. S100B may represent an additional diagnostic marker that in combination with the established techniques may improve the accuracy of IA diagnosis.
Frontiers in Microbiology
10.3389/fmicb.2016.00320
urn:nbn:de:bvb:20-opus-165386
Frontiers in Microbiology 2016 7:320. doi: 10.3389/fmicb.2016.00320
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Andreas Dix
Kristin Czakai
Jan Springer
Mirjam Fliesser
Michael Bonin
Reinhard Guthke
Anna L. Schmitt
Hermann Einsele
Jörg Linde
Jürgen Löffler
eng
uncontrolled
human biomarker
eng
uncontrolled
invasive aspergillosis
eng
uncontrolled
allogeneic stem cell transplantation
eng
uncontrolled
gene expression data
eng
uncontrolled
fungal infection
Medizin und Gesundheit
open_access
Medizinische Klinik und Poliklinik II
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16538/Dix_Frontiers_Microbiology_2016.pdf
17674
2018
eng
145
10
article
1
2019-02-15
--
--
Streptozotocin impairs proliferation and differentiation of adult hippocampal neural stem cells in vitro-correlation with alterations in the expression of proteins associated with the insulin system
Rats intracerebroventricularily (icv) treated with streptozotocin (STZ), shown to generate an insulin resistant brain state, were used as an animal model for the sporadic form of Alzheimer's disease (sAD). Previously, we showed in an in vivo study that 3 months after STZ icv treatment hippocampal adult neurogenesis (AN) is impaired. In the present study, we examined the effects of STZ on isolated adult hippocampal neural stem cells (NSCs) using an in vitro approach. We revealed that 2.5 mM STZ inhibits the proliferation of NSCs as indicated by reduced number and size of neurospheres as well as by less BrdU-immunoreactive NSCs. Double immunofluorescence stainings of NSCs already being triggered to start with their differentiation showed that STZ primarily impairs the generation of new neurons, but not of astrocytes. For revealing mechanisms possibly involved in mediating STZ effects we analyzed expression levels of insulin/glucose system-related molecules such as the glucose transporter (GLUT) 1 and 3, the insulin receptor (IR) and the insulin-like growth factor (IGF) 1 receptor. Applying quantitative Real time-PCR (qRT-PCR) and immunofluorescence stainings we showed that STZ exerts its strongest effects on GLUT3 expression, as GLUT3 mRNA levels were found to be reduced in NSCs, and less GLUT3-immunoreactive NSCs as well as differentiating cells were detected after STZ treatment. These findings suggest that cultured NSCs are a good model for developing new strategies to treat nerve cell loss in AD and other degenerative disorders.
Frontiers in Aging Neuroscience
10.3389/fnagi.2018.00145
urn:nbn:de:bvb:20-opus-176741
Frontiers in Aging Neuroscience 2018, Volume 10, Article 145. DOI: 10.3389/fnagi.2018.00145
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Ping Sun
Gabriela Ortega
Yan Tan
Qian Hua
Peter F. Riederer
Jürgen Deckert
Angelika G. Schmitt-Böhrer
eng
uncontrolled
Alzheimer’s disease
eng
uncontrolled
streptozotocin
eng
uncontrolled
proliferation
eng
uncontrolled
neural stem cells
eng
uncontrolled
insulin-like growth factor 1 receptor
eng
uncontrolled
insulin receptor
eng
uncontrolled
glucose transporter
eng
uncontrolled
differentiation
Krankheiten
open_access
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Förderzeitraum 2018
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/17674/Sun_Frontiers_in_Aging_Neuroscience.pdf
31934
2023
eng
11
12
article
1
--
2023-05-28
--
Physical function of RA patients tapering treatment — a post hoc analysis of the randomized controlled RETRO trial
Several studies have shown that tapering or stopping disease-modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis (RA) patients in sustained remission is feasible. However, tapering/stopping bears the risk of decline in physical function as some patients may relapse and face increased disease activity. Here, we analyzed the impact of tapering or stopping DMARD treatment on the physical function of RA patients. The study was a post hoc analysis of physical functional worsening for 282 patients with RA in sustained remission tapering and stopping DMARD treatment in the prospective randomized RETRO study. HAQ and DAS-28 scores were determined in baseline samples of patients continuing DMARD (arm 1), tapering their dose by 50% (arm 2), or stopping after tapering (arm 3). Patients were followed over 1 year, and HAQ and DAS-28 scores were evaluated every 3 months. The effect of treatment reduction strategy on functional worsening was assessed in a recurrent-event Cox regression model with a study-group (control, taper, and taper/stop) as the predictor. Two-hundred and eighty-two patients were analyzed. In 58 patients, functional worsening was observed. The incidences suggest a higher probability of functional worsening in patients tapering and/or stopping DMARDs, which is likely due to higher relapse rates in these individuals. At the end of the study, however, functional worsening was similar among the groups. Point estimates and survival curves show that the decline in functionality according to HAQ after tapering or discontinuation of DMARDs in RA patients with stable remission is associated with recurrence, but not with an overall functional decline.
Journal of Clinical Medicine
2077-0383
10.3390/jcm12113723
urn:nbn:de:bvb:20-opus-319349
2023-06-07T11:30:26+00:00
sword
swordwue
attachment; filename=deposit.zip
09a4d0bccad10e0d14898537102e0e2f
Journal of Clinical Medicine (2023) 12:11, 3723. https://doi.org/10.3390/jcm12113723
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Marlene Stephan
Koray Tascilar
Melek Yalcin-Mutlu
Melanie Hagen
Judith Haschka
Michaela Reiser
Fabian Hartmann
Arnd Kleyer
Axel J. Hueber
Bernhard Manger
Camille Figueiredo
Jayme Fogagnolo Cobra
Hans-Peter Tony
Stephanie Finzel
Stefan Kleinert
Jörg Wendler
Florian Schuch
Monika Ronneberger
Martin Feuchtenberger
Martin Fleck
Karin Manger
Wolfgang Ochs
Matthias Schmitt-Haendle
Hannes Martin Lorenz
Hubert Nüsslein
Rieke Alten
Joerg Henes
Klaus Krüger
Georg Schett
Jürgen Rech
eng
uncontrolled
HAQ
eng
uncontrolled
Rheumatoid Arthritis
eng
uncontrolled
PROM’s
eng
uncontrolled
DMARD
eng
uncontrolled
DAS28
Medizin und Gesundheit
open_access
Medizinische Klinik und Poliklinik II
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/31934/jcm-12-03723.pdf