13848
2015
eng
2843-2850
21
128
article
1
2016-09-19
--
--
Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey
Background: Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population.
Methods: A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging examination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH.
Results: NONFH was diagnosed in 218 subjects (0.725%) and the estimated NONFH cases were 8.12 million among Chinese people aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females (1.02% vs. 0.51%, \(\chi^2\) = 24.997, P < 0.001). Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents (0.85% vs. 0.61%, \(\chi^2\) = 5.847, P = 0.016). Our multivariate regression analysis showed that high blood levels of triglycerides, total cholesterol, LDL-cholesterol, and non-HDL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head, heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH.
Conclusions: Our findings highlight that NONFH is a significant public health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a number of risk factors with atherosclerosis.
Chinese Medical Journal
10.4103/0366-6999.168017
urn:nbn:de:bvb:20-opus-138482
Chinese Medical Journal 128, 21 (2015), pp. 2843-2850. doi:10.4103/0366-6999.168017
De-Wei Zhao
Mang Yu
Kai Hu
Wei Wang
Lei Yang
Ben-Jie Wang
Xiao-Hong Gao
Yong-Ming Guo
Yong-Qing Xu
Yu-Shan Wei
Si-Miao Tian
Fan Yang
Nan Wang
Shi-Bo Huang
Hui Xie
Xiao-Wei Wei
Hai-Shen Jiang
Yu-Qiang Zang
Jun Ai
Yuan-Liang Chen
Guang-Hua Lei
Yu-Jin Li
Geng Tian
Zong-Sheng Li
Yong Cao
Li Ma
eng
uncontrolled
nontraumatic osteonecrosis of the femoral head
eng
uncontrolled
risk factors
eng
uncontrolled
idiopathic osteonecrosis
eng
uncontrolled
early-stage osteonecrosis
eng
uncontrolled
implantation
eng
uncontrolled
bone
eng
uncontrolled
marrow
eng
uncontrolled
follow-up
eng
uncontrolled
intake
eng
uncontrolled
avascular necrosis
eng
uncontrolled
occupational-status
eng
uncontrolled
cigarette smoking
eng
uncontrolled
alcohol
eng
uncontrolled
prevalence
Medizin und Gesundheit
open_access
Medizinische Klinik und Poliklinik I
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13848/ChineseMedJournal.pdf
9719
2013
eng
article
1
--
--
--
The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed
Bone Morphogenetic Proteins (BMPs) are secreted protein hormones that act as morphogens and exert essential roles during embryonic development of tissues and organs. Signaling by BMPs occurs via hetero-oligomerization of two types of serine/threonine kinase transmembrane receptors. Due to the small number of available receptors for a large number of BMP ligands ligand-receptor promiscuity presents an evident problem requiring additional regulatory mechanisms for ligand-specific signaling. Such additional regulation is achieved through a plethora of extracellular antagonists, among them members of the Chordin superfamily, that modulate BMP signaling activity by binding. The key-element in Chordin-related antagonists for interacting with BMPs is the von Willebrand type C (VWC) module, which is a small domain of about 50 to 60 residues occurring in many different proteins. Although a structure of the VWC domain of the Chordin-member Crossveinless 2 (CV2) bound to BMP-2 has been determined by X-ray crystallography, the molecular mechanism by which the VWC domain binds BMPs has remained unclear. Here we present the NMR structure of the Danio rerio CV2 VWC1 domain in its unbound state showing that the key features for high affinity binding to BMP-2 is a pre-oriented peptide loop.
Molecules
10.3390/molecules181011658
urn:nbn:de:bvb:20-opus-97196
In: Molecules (2013) 18: 10, 11658-11682, doi:10.3390/molecules181011658
Thomas D. Mueller
Juliane E. Fiebig
Stella E. Weidauer
Li-Yan Qiu
Markus Bauer
Peter Schmieder
Monika Beerbaum
Jin-Li Zhang
Hartmut Oschkinat
Walter Sebald
eng
uncontrolled
bone morphogenetic proteins
eng
uncontrolled
TGF-β superfamily
eng
uncontrolled
BMP antagonist
eng
uncontrolled
protein-protein recognition
eng
uncontrolled
NMR spectroscopy
eng
uncontrolled
von Willebrand type C domain
Medizin und Gesundheit
open_access
Theodor-Boveri-Institut für Biowissenschaften
Julius-von-Sachs-Institut für Biowissenschaften
Förderzeitraum 2013
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/9719/Mueller_molecules181011658.pdf
13983
2015
eng
8804
6
article
1
2016-10-27
--
--
Meta-analysis identifies seven susceptibility loci involved in the atopic march
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P = 2.1 x 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P = 5.3 x 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.
Nature Communications
10.1038/ncomms9804
urn:nbn:de:bvb:20-opus-139835
Nature Communications 6:8804 doi: 10.1038/ncomms9804 (2015).
Ingo Marenholz
Jorge Esparza-Gordillo
Franz Rüschendorf
Anja Bauerfeind
David P. Strachan
Ben D. Spycher
Hansjörg Baurecht
Patricia Magaritte-Jeannin
Annika Sääf
Marjan Kerkhof
Markus Ege
Svetlana Baltic
Melanie C. Matheson
Jin Li
Sven Michel
Wei Q. Ang
Wendy McArdle
Andreas Arnold
Georg Homuth
Florence Demenais
Emmanuelle Bouzigon
Cilla Söderhäll
Göran Pershagen
Johan C. de Jongste
Dirkje S. Postma
Charlotte Braun-Fahrländer
Elisabeth Horak
Ludmila M. Ogorodova
Valery P. Puzyrev
Elena Yu Bragina
Thomas J. Hudson
Charles Morin
David L. Duffy
Guy B. Marks
Colin F. Robertson
Grant W. Montgomery
Bill Musk
Philip J. Thompson
Nicholas G. Martin
Alan James
Patrick Sleiman
Elina Toskala
Elke Rodriguez
Regina Fölster-Holst
Andre Franke
Wolfgang Lieb
Christian Gieger
Andrea Heinzmann
Ernst Rietschel
Thomas Keil
Sven Cichon
Markus M. Nöthen
Craig E. Pennel
Peter D. Sly
Carsten O. Schmidt
Anja Matanovic
Valentin Schneider
Matthias Heinig
Norbert Hübner
Patrick G. Holt
Susanne Lau
Michael Kabesch
Stefan Weidinger
Hakon Hakonarson
Manuel A. R. Ferreira
Catherine Laprise
Maxim B. Freidin
Jon Genuneit
Gerard H. Koppelman
Erik Melén
Marie-Hélène Dizier
A. John Henderson
Young Ae Lee
eng
uncontrolled
chromosome 11Q13
eng
uncontrolled
risk
eng
uncontrolled
genomewide association
eng
uncontrolled
hay fever
eng
uncontrolled
birth cohort
eng
uncontrolled
filaggrin mutations
eng
uncontrolled
food allergy
eng
uncontrolled
juvenile myoclonic epilepsy
eng
uncontrolled
childhood asthma
eng
uncontrolled
dermatitis
Medizin und Gesundheit
open_access
Institut für Klinische Epidemiologie und Biometrie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13983/ncomms9804.pdf
17084
2017
eng
7
6
article
1
2018-10-31
--
--
The draft genome of blunt snout bream (Megalobrama amblycephala) reveals the development of intermuscular bone and adaptation to herbivorous diet
The blunt snout bream Megalobrama amblycephala is the economically most important cyprinid fish species. As an herbivore, it can be grown by eco-friendly and resource-conserving aquaculture. However, the large number of intermuscular bones in the trunk musculature is adverse to fish meat processing and consumption. As a first towards optimizing this aquatic livestock, we present a 1.116-Gb draft genome of M. amblycephala, with 779.54 Mb anchored on 24 linkage groups. Integrating spatiotemporal transcriptome analyses, we show that intermuscular bone is formed in the more basal teleosts by intramembranous ossification and may be involved in muscle contractibility and coordinating cellular events. Comparative analysis revealed that olfactory receptor genes, especially of the beta type, underwent an extensive expansion in herbivorous cyprinids, whereas the gene for the umami receptor T1R1 was specifically lost in M. amblycephala. The composition of gut microflora, which contributes to the herbivorous adaptation of M. amblycephala, was found to be similar to that of other herbivores. As a valuable resource for the improvement of M. amblycephala livestock, the draft genome sequence offers new insights into the development of intermuscular bone and herbivorous adaptation.
GigaScience
10.1093/gigascience/gix039
urn:nbn:de:bvb:20-opus-170844
GigaScience 2017, Volume 6, Issue 7. DOI: 10.1093/gigascience/gix039
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Han Liu
Chunhai Chen
Zexia Gao
Jiumeng Min
Yongming Gu
Jianbo Jian
Xiewu Jiang
Huimin Cai
Ingo Ebersberger
Meng Xu
Xinhui Zhang
Jianwei Chen
Wei Luo
Boxiang Chen
Junhui Chen
Hong Liu
Jiang Li
Ruifang Lai
Mingzhou Bai
Jin Wei
Shaokui Yi
Huanling Wang
Xiaojuan Cao
Xiaoyun Zhou
Yuhua Zhao
Kaijian Wei
Ruibin Yang
Bingnan Liu
Shancen Zhao
Xiaodong Fang
Manfred Schartl
Xueqiao Qian
Weimin Wang
eng
uncontrolled
Megalobrama amblycephala
eng
uncontrolled
whole genome
eng
uncontrolled
herbivorous diet
eng
uncontrolled
intermuscular bone
eng
uncontrolled
transcriptome
eng
uncontrolled
gut microflora
Medizin und Gesundheit
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/17084/069_Liu_GIGASCIENCE.pdf