6254
2010
eng
article
1
2012-11-12
--
--
Genomic Damage in Endstage Renal Disease - Contribution of Uremic Toxins
Patients with end-stage renal disease (ESRD), whether on conservative, peritoneal or hemodialysis therapy, have elevated genomic damage in peripheral blood lymphocytes and an increased cancer incidence, especially of the kidney. The damage is possibly due to accumulation of uremic toxins like advanced glycation endproducts or homocysteine. However, other endogenous substances with genotoxic properties, which are increased in ESRD, could be involved, such as the blood pressure regulating hormones angiotensin II and aldosterone or the inflammatory cytokine TNF-. This review provides an overview of genomic damage observed in ESRD patients, focuses on possible underlying causes and shows modulations of the damage by modern dialysis strategies and vitamin upplementation.
urn:nbn:de:bvb:20-opus-68653
6865
In: Toxins (2010) 2, 2340-2358, DOI: 10.3390/toxins2102340
Nicole Schupp
August Heidland
Helga Stopper
deu
swd
Toxin
eng
uncontrolled
dialysis
eng
uncontrolled
genotoxicity
eng
uncontrolled
uremic toxins
Chemie und zugeordnete Wissenschaften
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6254/Stopper090_toxins_02_02340.pdf
16656
2016
eng
3592042
2016
article
1
2018-08-06
--
--
DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers
Patients with chronic kidney disease (CKD) exhibit an increased cancer risk compared to a healthy control population. To be able to estimate the cancer risk of the patients and to assess the impact of interventional therapies thereon, it is of particular interest to measure the patients’ burden of genomic damage. Chromosomal abnormalities, reduced DNA repair, and DNA lesions were found indeed in cells of patients with CKD. Biomarkers for DNA damage measurable in easily accessible cells like peripheral blood lymphocytes are chromosomal aberrations, structural DNA lesions, and oxidatively modified DNA bases. In this review the most common methods quantifying the three parameters mentioned above, the cytokinesis-block micronucleus assay, the comet assay, and the quantification of 8-oxo-7,8-dihydro-2′-deoxyguanosine, are evaluated concerning the feasibility of the analysis and regarding the marker’s potential to predict clinical outcomes.
Oxidative Medicine and Cellular Longevity
10.1155/2016/3592042
urn:nbn:de:bvb:20-opus-166569
Oxidative Medicine and Cellular Longevity, Volume 2016, Article ID 3592042. DOI: 10.1155/2016/3592042
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Nicole Schupp
Helga Stopper
August Heidland
eng
uncontrolled
chronic kidney disease
eng
uncontrolled
cancer risk
eng
uncontrolled
DNA damage
eng
uncontrolled
biomarkers
Medizin und Gesundheit
open_access
Institut für Pharmakologie und Toxikologie
Medizinische Klinik und Poliklinik I
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16656/Schupp_Oxidative_Medicine_and_Cellular_Longevity.pdf