16125
2018
eng
article
1
2018-04-29
--
--
Predictive value of \(^{18}\)F-FDG PET in patients with advanced medullary thyroid carcinoma treated with vandetanib
Introduction: Therapeutic options in advanced medullary thyroid carcinoma (MTC) have markedly improved since the introduction of tyrosine kinase inhibitors (TKI). We
aimed to assess the role of metabolic imaging using 2-deoxy-2-(\(^{18}\)F)fluoro-D-glucose (\(^{18}\)F-FDG) positron emission tomography/computed tomography (PET/CT) shortly before and 3 months after initiation of TKI treatment.
Methods: Eighteen patients with advanced and progressive MTC scheduled for vandetanib treatment underwent baseline \(^{18}\)F-FDG PET/CT prior to and 3 months after TKI treatment initiation. During follow-up, CT scans were performed every 3 months and analyzed according to Response Evaluation Criteria In Solid Tumors (RECIST). The predictive value for estimating progression-free (PFS) and overall survival (OS) was examined by investigating \(^{18}\)F-FDG mean/maximum standardized uptake values (SUVmean/max) of the metabolically most active lesion as well as by analyzing clinical parameters (tumor marker doubling times {calcitonin, carcinoembryonic antigen (CEA)}, prior therapies, RET (rearranged during transfection) mutational status, and disease type).
Results: Within a median follow-up of 5.2 years, 9 patients experienced disease progression after a median time interval of 2.1y whereas the remainder had ongoing disease control (n=5 partial response and n=4 stable disease). Eight of the 9 patients with progressive disease died from MTC after a median of 3.5y after TKI initiation.
Pre-therapeutic SUVmean >4.0 predicted a significantly shorter PFS (PFS: 1.9y vs. 5.2y; p=0.04). Furthermore, sustained high 18F-FDG uptake at 3 months with a SUVmean>2.8 tended to portend an unfavorable prognosis with a PFS of 1.9y (vs. 3.5y; p=0.3). Prolonged CEA doubling times were significantly correlated with longer PFS (r=0.7) and OS (r=0.76, p<0.01, respectively). None of the other clinical parameters had prognostic significance.
Conclusions: Pre-therapeutic \(^{18}\)F-FDG PET/CT holds prognostic information in patients with advanced MTC scheduled for treatment with the TKI vandetanib. Low tumor metabolism of SUVmean < 4.0 prior to treatment predicts longer progression-free survival.
Journal of Nuclear Medicine
10.2967/jnumed.117.199778
0161-5505
https://www.ncbi.nlm.nih.gov/pubmed/29025983
urn:nbn:de:bvb:20-opus-161256
This research was originally published in JNM. Rudolf A. Werner, Jan-Stefan Schmid, Takahiro Higuchi, Mehrbod S. Javadi, Steven P. Rowe, Bruno Märkl, Christoph Aulmann, Martin Fassnacht, Matthias Kroiss, Christoph Reiners, Andreas K. Buck, Michael C. Kreissl, Constantin Lapa. Predictive value of 18F-FDG PET in patients with advanced medullary thyroid carcinoma treated with vandetanib. J Nucl Med. May 1, 2018;vol. 59 no. 5: 756-761. © SNMMI.
Johns Hopkins University School of Medicine
Journal of Nuclear Medicine May 1, 2018 vol. 59 no. 5 756-761. doi:10.2967/jnumed.117.199778
701983
Deutsches Urheberrecht
Rudolf Werner
Jan-Stefan Schmid
Takahiro Higuchi
Mehrbod S. Javadi
Steven P. Rowe
Bruno Märkl
Christoph Aulmann
Martin Fassnacht
Matthias Kroiß
Christoph Reiners
Andreas Buck
Michael Kreissl
Constantin Lapa
eng
uncontrolled
positron emission tomography
deu
swd
Medullärer Schilddrüsenkrebs
deu
swd
Positronen-Emissions-Tomografie
eng
uncontrolled
medullary thyroid carcinoma
eng
uncontrolled
tyrosine kinase inhibitor
eng
uncontrolled
vandetanib
eng
uncontrolled
2- deoxy-2-(18F)fluoro-D-glucose
eng
uncontrolled
18F-FDG
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Medizinische Klinik und Poliklinik I
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16125/Werner_Rudolf_Vandetanib_JNM_accepted_version.pdf
16127
2018
eng
article
1
2018-04-29
--
--
Functional renal imaging with \(^{18}\)F-FDS PET in rat models of renal disorders
Background: Precise regional quantitative assessment of renal function is limited with conventional \(^{99m}\)Tc-labeled renal radiotracers. A recent study reported that the positron emission tomography (PET) radiotracer 2-deoxy-2-(\(^{18}\)F-fluorosorbitol (\(^{18}\)F-FDS) has ideal pharmacokinetics for functional renal imaging. Furthermore, (\(^{18}\)F-FDS is available via simple reduction from routinely used 2-deoxy-2-(\(^{18}\)F-fluoro-D-glucose ((\(^{18}\)F-FDG). We aimed to further investigate the potential of (\(^{18}\)F-FDS PET as a functional renal imaging agent using rat models of kidney diseases.
Methods: Two different rat models of renal impairment were investigated: Glycerol induced acute renal failure (ARF) by intramuscular administration of glycerol in hind legs and unilateral ureteral obstruction (UUO) by ligation of the left ureter. 24h after these treatments, dynamic 30 min 18F-FDS PET data were acquired using a dedicated small animal PET system. Urine 18F-FDS radioactivity 30 min after radiotracer injection was measured together with co-injected \(^{99m}\)Tc-diethylenetriaminepentaacetic acid (\(^{99m}\)Tc-DTPA) urine activity. Results: Dynamic PET imaging demonstrated rapid (\(^{18}\)F-FDS accumulation in the renal cortex and rapid radiotracer excretion via kidneys in control healthy rats. On the other hand, significantly delayed renal radiotracer uptake (continuous slow uptake) was observed in ARF rats and UUO-treated kidneys. Measured urine radiotracer concentrations of (\(^{18}\)F-FDS and \(^{99m}\)Tc-DTPA were well correlated (R=0.84, P<0.05).
Conclusions: (\(^{18}\)F-FDS PET demonstrated favorable kinetics for functional renal imaging in rat models of kidney diseases. Advantages of high spatiotemporal resolution of PET imaging and simple tracer production could potentially complement or replace conventional renal scintigraphy in select cases and significantly improve the diagnostic performance of renal functional imaging.
Journal of Nuclear Medicine
10.2967/jnumed.117.203828
0161-5505
29242399
urn:nbn:de:bvb:20-opus-161279
This research was originally published in JNM. Rudolf A. Werner, Hiroshi Wakabayashi, Xinyu Chen, Mitsuru Hirano, Tetsuya Shinaji, Constantin Lapa, Steven P. Rowe, Mehrbod S. Javadi and Takahiro Higuchi. Functional renal imaging with 18F-FDS PET in rat models of renal disorders. J Nucl Med. May 1, 2018;vol. 59 no. 5: 828-832. © SNMMI.
Johns Hopkins University School of Medicine
Journal of Nuclear Medicine May 1, 2018 vol. 59 no. 5 828-832. doi:10.2967/jnumed.117.203828
701983
Deutsches Urheberrecht
Rudolf Werner
Hiroshi Wakabyashi
Xinyu Chen
Mitsuru Hirano
Tetsuya Shinaji
Constantin Lapa
Steven Rowe
Mehrbod Javadi
Takahiro Higuchi
eng
uncontrolled
unilateral ureteral obstruction
deu
swd
Nierenfunktionsstörung
deu
swd
Positronen-Emissions-Tomografie
eng
uncontrolled
18F-FDS
eng
uncontrolled
99mTc-DTPA
eng
uncontrolled
PET
eng
uncontrolled
renal failure
eng
uncontrolled
Glomerular filtration
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16127/Werner_Rudolf_Kidney_JNM_accepted_version.pdf
16129
2018
eng
article
1
2018-04-29
--
--
SSTR-RADS Version 1.0 as a Reporting System for SSTR-PET Imaging and Selection of Potential PRRT Candidates: A Proposed Standardization Framework
Reliable standards and criteria for somatostatin receptor (SSTR) positron emission tomography (PET) are still lacking. We herein propose a structured reporting system on a 5-point scale for SSTR-PET imaging, titled SSTR-RADS version 1.0, which might serve as a standardized assessment for both diagnosis and treatment planning in neuroendocrine tumors (NET). SSTR-RADS could guide the imaging specialist in interpreting SSTR-PET scans, facilitate communication with the referring clinician so that appropriate work-up for equivocal findings is pursued, and serve as a reliable tool for patient selection for planned Peptide Receptor Radionuclide Therapy.
Journal of Nuclear Medicine
10.2967/jnumed.117.206631
0161-5505
29572257
urn:nbn:de:bvb:20-opus-161298
This research was originally published in JNM. Rudolf A. Werner, Lilja B. Solnes, Mehrbod Som Javadi, Alexander Weich, Michael A. Gorin, Kenneth J. Pienta, Takahiro Higuchi, Andreas K. Buck, Martin G. Pomper, Steven P. Rowe, Constantin Lapa. SSTR-RADS Version 1.0 as a Reporting System for SSTR-PET Imaging and Selection of Potential PRRT Candidates: A Proposed Standardization Framework. J. Nucl. Med. July 1, 2018, vol. 59, no. 7, 1085-1091. © SNMMI
Johns Hopkins University School of Medicine
701983
Journal of Nuclear Medicine July 1, 2018 vol. 59 no. 7 1085-1091 © SNMMI
Deutsches Urheberrecht
Rudolf Werner
Lilja Solnes
Mehrbod Javadi
Alexander Weich
Michael Gorin
Kenneth Pienta
Takahiro Higuchi
Andreas Buck
Martin Pomper
Steven Rowe
Constantin Lapa
eng
uncontrolled
Radionuclide Therapy
deu
swd
Standardisierung
deu
swd
Positronen-Emissions-Tomografie
eng
uncontrolled
68Ga-DOTATATE/-TOC
eng
uncontrolled
Gastrointestinal
eng
uncontrolled
Neuroendocrine
eng
uncontrolled
Neuroendocrine Tumor
eng
uncontrolled
Oncology
eng
uncontrolled
GI
eng
uncontrolled
PET
eng
uncontrolled
PET/CT
eng
uncontrolled
PRRT
eng
uncontrolled
RADS
eng
uncontrolled
SSTR
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Medizinische Klinik und Poliklinik II
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16129/Werner_Rudolf_Standardization_JNM_accepted_version.pdf
16560
2018
eng
1-8
article
1
2018-07-24
--
--
Longitudinal \(^{18}\)F-FDG PET imaging in a Rat Model of Autoimmune Myocarditis
Aims: Although mortality rate is very high, diagnosis of acute myocarditis remains challenging with conventional tests. We aimed to elucidate the potential role of longitudinal 2-Deoxy-2-\(^{18}\)F-fluoro-D-glucose (\(^{18}\)F-FDG) positron emission tomography (PET) inflammation monitoring in a rat model of experimental autoimmune myocarditis.
Methods and results: Autoimmune myocarditis was induced in Lewis rats by immunizing with porcine cardiac myosin emulsified in complete Freund’s adjuvant. Time course of disease was assessed by longitudinal \(^{18}\)F-FDG PET imaging. A correlative analysis between in- and ex vivo \(^{18}\)F-FDG signalling and macrophage infiltration using CD68 staining was conducted. Finally, immunohistochemistry analysis of the cell-adhesion markers CD34 and CD44 was performed at different disease stages determined by longitudinal \(^{18}\)F-FDG PET imaging. After immunization, myocarditis rats revealed a temporal increase in 18F-FDG uptake (peaked at week 3), which was followed by a rapid decline thereafter. Localization of CD68 positive cells was well correlated with in vivo \(^{18}\)F-FDG PET signalling (R\(^2\) = 0.92) as well as with ex vivo 18F-FDG autoradiography (R\(^2\) = 0.9, P < 0.001, respectively). CD44 positivity was primarily observed at tissue samples obtained at acute phase (i.e. at peak 18F-FDG uptake), while CD34-positive staining areas were predominantly identified in samples harvested at both sub-acute and chronic phases (i.e. at \(^{18}\)F-FDG decrease).
Conclusion: \(^{18}\)F-FDG PET imaging can provide non-invasive serial monitoring of cardiac inflammation in a rat model of acute myocarditis.
European Heart Journal Cardiovascular Imaging
2047-2404
10.1093/ehjci/jey119
urn:nbn:de:bvb:20-opus-165601
Johns Hopkins School of Medicine
701983
European Heart Journal - Cardiovascular Imaging (2018) 0, 1–8 doi:10.1093/ehjci/jey119
CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International
Rudolf Werner
Hiroshi Wakabayashi
Jochen Bauer
Claudia Schütz
Christina Zechmeister
Nobuyuki Hayakawa
Mehrbod S. Javadi
Constantin Lapa
Roland Jahns
Süleyman Ergün
Valerie Jahns
Takahiro Higuchi
eng
uncontrolled
positron emission tomography
deu
swd
Myokarditis
eng
uncontrolled
myocarditis
eng
uncontrolled
inflammation
eng
uncontrolled
18F-FDG
eng
uncontrolled
PET
eng
uncontrolled
personalized treatment
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für Pharmakologie und Toxikologie
Institut für Anatomie und Zellbiologie
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16560/Werner_EHJ_Cardiovascular_Imaging_2018.pdf
17028
2018
eng
1-9
article
1
2018-10-27
--
--
Impact of Tumor Burden on Quantitative [\(^{68}\)Ga]DOTATOC Biodistribution
Purpose: As has been previously reported, the somatostatin receptor (SSTR) imaging agent [\(^{68}\)Ga]-labeled 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotate ([\(^{68}\)Ga]DOTATATE) demonstrates lower uptake in normal organs in patients with a high neuroendocrine tumor (NET) burden. Given the higher SSTR affinity of [\(^{68}\)Ga]DOTATATE, we aimed to quantitatively investigate the biodistribution of [\(^{68}\)Ga]-labeled 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotide ([68Ga]DOTATOC) to determine a potential correlation between uptake in normal organs and NET burden.
Procedures: Of the 44 included patients, 36/44 (82%) patients demonstrated suspicious radiotracer uptake on [\(^{68}\)Ga]DOTATOC positron emission tomography (PET)/x-ray computed tomography (CT). Volumes of Interest (VOIs) were defined for tumor lesions and normal organs (spleen, liver, kidneys, adrenals). Mean body weight corrected standardized uptake value (SUV\(_{mean}\)) for normal organs was assessed and was used to calculate the corresponding mean specific activity uptake (Upt: fraction of injected activity per kg of tissue). For the entire tumor burden, SUV\(_{mean}\), maximum standardized uptake value (SUV\(_{max}\)), and the total mass (TBM) was calculated and the decay corrected tumor fractional uptake (TBU) was assessed. A Spearman’s rank correlation coefficient was used to determine the correlations between normal organ uptake and tumor burden.
Results: The median SUV\(_{mean}\) was 18.7 for the spleen (kidneys, 9.2; adrenals, 6.8; liver, 5.6). For tumor burden, the median values were SUV\(_{mean}\) 6.9, SUV\(_{max}\) 35.5, TBM 42.6g, and TBU 1.2%. With increasing volume of distribution, represented by lean body mass and body surface area (BSA), Upt decreased in kidneys, liver, and adrenal glands and SUV\(_{mean}\) increased in the spleen. Correlation improved only for both kidneys and adrenals when the influence of the tumor uptake on the activity available for organ uptake was taken into account by the factor 1/(1-TBU). TBU was neither predictive for SUV\(_{mean}\) nor for Upt in any of the organs. The distribution of organ Upt vs. BSA/(1-TBU) were not different for patients with minor TBU (<3%) vs. higher TBU (>7%), indicating that the correlations observed in the present study are explainable by the body size effect. High tumor mass and uptake mitigated against G1 NET.
Conclusions: There is no significant impact on normal organ biodistribution with increasing tumor burden on [\(^{68}\)Ga]DOTATOC PET/CT. Potential implications include increased normal organ dose with [\(^{177}\)Lu-DOTA]\(^0\)-D-Phe\(^1\)-Tyr\(^3\)-Octreotide and decreased absolute lesion detection with [\(^{68}\)Ga]DOTATOC in high NET burden.
Molecular Imaging and Biology
urn:nbn:de:bvb:20-opus-170280
Johns Hopkins School of Medicine
Molecular Imaging and Biology (2018). https://doi.org/10.1007/s11307-018-1293-9
701983
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Rudolf Werner
Heribert Hänscheid
Jeffrey P. Leal
Mehrbod S. Javadi
Takahiro Higuchi
Martin A. Lodge
Andreas K. Buck
Martin G. Pomper
Constantin Lapa
Steven P. Rowe
eng
uncontrolled
somatostatin receptor
deu
swd
Positronen-Emissions-Tomografie
eng
uncontrolled
quantification
eng
uncontrolled
[68Ga]DOTATOC
eng
uncontrolled
neuroendocrine tumor
eng
uncontrolled
SSTR-PET
eng
uncontrolled
theranostics
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/17028/Rudolf_Werner_MIB_2018_ImpactOfTumorBurden.pdf
16139
2017
deu
Abstract Nr.: V119
2
56
conferenceobject
Schattauer Verlag
1
2018-05-02
--
--
Bildgebung der frühen linksventrikulären Dysfunktion mit ECG-gated F-18-FDG PET in einem Diabetes-Ratten-Modell
Einleitung: Die linksventrikuläre diastolische Dysfunktion (LVDD) ist bei Diabetikern noch vor Entwicklung einer klinisch apparenten Herzinsuffizienz eines der ersten Anzeichen einer kardialen Beteiligung. Daher soll in dieser Studie untersucht werden, ob die LVDD mit ECG-gated F-18-FDG PET in einem Diabetes-Rattenmodell dargestellt werden kann.
Methodik: Es wurden F-18-FDG PET Scans in einem Typ-2-Diabetes Rattenmodell (ZDF fa/fa, n=6) und in ZL Kontrollen (n=6) vorgenommen (Alter, jeweils 13 Wochen). Unter Hyperinsulinemic-Euglycemic Clamp-Technik wurden 37 MBq 18F-FDG über die Schwanzvene appliziert. 15-35 Minuten nach Tracergabe wurden mittels eines Kleintier-PET-Scanners sowie unter EKG-Ableitung PET Scans angefertigt (16 frames/cardiac cycle). Die linksventrikuläre Ejektionsfraktion (EF) und die Peak Füllrate (PFR) wurden mittels einer geeigneten Software (Heart Function View) gemessen, wobei die Software an die Größe des Rattenherzes angepasst wurde.
Ergebnisse: Im Alter von 13 Wochen entwickeln ZDF Diabetes-Ratten eine im Vergleich zu Kontrolltieren eine signifikante myokardiale Hypertrophie, bestätigt durch post-mortem Analyse des Herzgewichtes (994±78mg vs. 871±44mg in ZDF Diabetes-Ratten vs. ZL Kontrollen, p<0.01). ECG-gated PET zeigte eine signifikante Abnahme der LV diastolischen PFR (10.4±0.5 vs. 11.8±0.4 EDV/sec in ZDF Diabetes-Ratten vs. ZL Kontrollen, p<0.001), jedoch zeigte sich kein signifikanter Unterschied zwischen LVEF und der Herzfrequenz in den untersuchten ZDF Diabetes-Ratten und Kontrollen (LVEF: 60.0±4.5 vs. 63.7±4.1%, n.s. und HR: 305±25 vs. 323±24 bpm, n.s.).
Schlussfolgerung: Im Diabetes-Ratten-Modell kann unter Verwendung eines ECG-gated FDG-PET Protokolls die diastolische Dysfunktion als Parameter der frühen diabetischen Kardiomyopathie nachgewiesen werden.
Nuklearmedizin
http://www.nuklearmedizin.de/jahrestagungen/abstr_online2017/print_abstract_pdf.php
0029-5566
10.3413/Nukmed-0880-17-02
urn:nbn:de:bvb:20-opus-161396
This article is not an exact copy of the original published article in Nuklearmedizin.
The definitive publisher-authenticated version of „Bildgebung der frühen linksventrikulären Dysfunktion mit ECG-gated F-18-FDG PET in einem Diabetes-Ratten-Modell. Nuklearmedizin 2017; 56 (Abstract Nr.: V119).“ is available online at http://www.nuklearmedizin.de/jahrestagungen/abstr_online2017/print_abstract_pdf.php
Johns Hopkins School of Medicine
701983
Nuklearmedizin 2017 (Vol. 56): Heft 2 (A41-A42). doi:10.3413/Nukmed-0880-17-02
Deutsches Urheberrecht
Rudolf Werner
Nobuyuki Hayakawa
Paula-Anah Arias-Loza
Hiroshi Wakabayashi
Tetsuya Shinaji
Constantin Lapa
Theo Pelzer
Takahiro Higuchi
deu
swd
Positronen-Emissions-Tomografie
deu
uncontrolled
Diabetes
deu
uncontrolled
diabetische Kardiomyopathie
deu
uncontrolled
Positronen-Emissions-Tomografie
deu
uncontrolled
PET
deu
uncontrolled
EKG
deu
uncontrolled
ECG
deu
uncontrolled
ECG-gated
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Medizinische Klinik und Poliklinik I
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16139/Werner_Rudolf_Diabetische Kardiomyopathie_accepted_version.pdf
16111
2017
eng
i52-53
Supplement
18
conferenceobject
Oxford University Press
1
2018-04-25
--
--
Effect of Antidepressants on Radiolabeled Metaiodobenzylguanidine (MIBG) Uptake
No abstract available.
European Heart Journal - Cardiovascular Imaging
10.1093/ehjci/jex080
2047-2404
urn:nbn:de:bvb:20-opus-161116
This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of
record Eur Heart J Cardiovasc Imaging. ISSN: 2047-2404. Supplement, vol. 18, i52-53, May 2017 is available online at: 10.1093/ehjci/jex080.
701983
European Heart Journal - Cardiovascular Imaging. Supplement, vol. 18, i52-53, May 2017. doi: 10.1093/ehjci/jex080
Johns Hopkins School of Medicine, Baltimore, MD, U.S.
Deutsches Urheberrecht
Rudolf Werner
Ryohei Kobayashi
Hiroshi Wakabayashi
Constantin Lapa
Andreas Menke
Takahiro Higuchi
deu
swd
MIBG
eng
uncontrolled
Metaiodobenzylguanidine
eng
uncontrolled
mIBG
eng
uncontrolled
antidepressants
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16111/Werner_Rudolf_mIBG .pdf
16112
2017
eng
i1-i3
Supplement
18
conferenceobject
Oxford University Press
1
2018-04-25
--
--
PET-Guided Histological Characterization of Myocardial Infiltrating Cells in a Rat Model of Myocarditis
No abstract available.
European Heart Journal - Cardiovascular Imaging
2047-2404
10.1093/ehjci/jex071
urn:nbn:de:bvb:20-opus-161127
This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of record . Eur Heart J Cardiovasc Imaging. ISSN: 2047-2404. Supplement, vol. 18, i1-i3, May 2017 is available online at: 10.1093/ehjci/jex071.
European Heart Journal - Cardiovascular Imaging, Volume 18, Issue suppl_1, May 2017, Pages i1–i3, https://doi.org/10.1093/ehjci/jex071
701983
Johns Hopkins School of Medicine, Baltimore, MD, U.S.
Deutsches Urheberrecht
Rudolf Werner
Hiroshi Wakabayashi
Roland Jahns
Süleyman Ergün
Valerie Jahns
Takahiro Higuchi
deu
swd
Myokarditis
eng
uncontrolled
positron emission tomography
eng
uncontrolled
myocarditis
eng
uncontrolled
PET
eng
uncontrolled
18F-FDG
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für Pharmakologie und Toxikologie
Institut für Anatomie und Zellbiologie
Medizinische Klinik und Poliklinik I
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16112/Werner_Rudolf_Myocarditis.pdf
16113
2017
eng
1461-1496
4 Supplement (2017) Aug
24
conferenceobject
1
2018-04-25
--
--
Intracellular behavior of the novel sympathetic nerve agent \(^{18}\)F-LMI1195
No abstract available.
Journal of Nuclear Cardiology
10.1007/s12350-017-0984-y
1071-3581
urn:nbn:de:bvb:20-opus-161137
This is a post-peer-review, pre-copyedit version of an article published in J Nucl Cardiol. ISSN: 1071-3581. Supplement (2017) Aug;24;4: 1461-1496. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12350-017-0984-y
Johns Hopkins University School of Medicine, Baltimore, MD, U.S.
Journal of Nuclear Cardiology August 2017, Volume 24, Issue 4, Supplement, pp 1461–1496. doi:10.1007/s12350-017-0984-y
701983
Deutsches Urheberrecht
Rudolf Werner
Xinyu Chen
Constantin Lapa
Simon Robinson
Takahiro Higuchi
deu
swd
Herz
eng
uncontrolled
PET
eng
uncontrolled
sympathetic nerve
eng
uncontrolled
autonomic nervous system
eng
uncontrolled
18F-LMI1195
eng
uncontrolled
positron emission tomography
eng
uncontrolled
heart
eng
uncontrolled
cardiac
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16113/Werner_Rudolf_18F-LMI1195.edited.pdf
16114
2017
eng
169
no. supplement 1
58
conferenceobject
1
2018-04-25
--
--
Predictive value of FDG-PET in patients with advanced medullary thyroid cancer undergoing vandetanib treatment
Introduction: The prognosis of medullary thyroid carcinoma (MTC) is poor using common chemotherapeutic approaches. However, during the last years encouraging results of recently introduced tyrosine kinase inhibitors (TKI) such as vandetanib have been published. In this study we aimed to correlate the results of \(^{18}\)F-fluorodeoxyglucose ([\(^{18}\)F]FDG) positron emission tomography (PET) imaging with treatment outcome.
Methods: Eighteen patients after thyroidectomy with recurrent/advanced MTC lesions receiving vandetanib (300 mg orally/day) could be analysed. A baseline \(^{18}\)F-FDG PET prior to and a follow-up \(^{18}\)F-FDG PET 3 months after TKI initiation were performed. During follow-up, tumor progression was assessed every 3 months including computed tomography according to RECIST. Progression-free survival (PFS) was correlated with the maximum standardized uptake value of \(^{18}\)F-FDG in lymph nodes (SUV(LN)max) or visceral metastases (SUV(MTS)max) as well as with clinical parameters using ROC analysis.
Results: Within median 3.6 years of follow-up, 9 patients showed disease progression at median 8.5 months after TKI initiation. An elevated glucose consumption assessed by baseline \(^{18}\)F-FDG PET (SUV(LN)max > 7.25) could predict a shorter PFS (2 y) with an accuracy of 76.5% (SUV(LN)max <7.25, 4.3 y; p=0.03). Accordingly, preserved tumor metabolism in the follow-up PET (SUV(MTS)max >2.7) also demonstrated an unfavorable prognosis (accuracy, 85.7%). On the other hand, none of the clinical parameters reached significance in response prediction.
Conclusions: In patients with advanced and progressive MTC, tumors with higher metabolic activity at baseline are more aggressive and more prone to progression as reflected by a shorter PFS; they should be monitored more closely. Preserved glucose consumption 3 months after treatment initiation was also related to poorer prognosis.
Journal of Nuclear Medicine
0161-5505
http://jnm.snmjournals.org/content/58/supplement_1/169
urn:nbn:de:bvb:20-opus-161147
This research was originally published in JNM.
Rudolf A. Werner, Takahiro Higuchi, Dirk O. Muegge, Mehrbod S. Javadi, B. Märkl, C. Aulmann, Andreas K. Buck, Martin Fassnacht, Constantin Lapa, Michael C. Kreissl.
Predictive value of FDG-PET in patients with advanced medullary thyroid cancer undergoing vandetanib treatment. J Nucl Med. May 1, 2017; vol. 58 no. supplement 1:169. © SNMMI.
Johns Hopkins School of Medicine, Baltimore, MD, U.S.
Hospital Augsburg, Augsburg, Germany
Journal of Nuclear Medicine May 1, 2017 vol. 58 no. supplement 1 169
701983
Deutsches Urheberrecht
Rudolf Werner
Takahiro Higuchi
Dirk Muegge
Mehrbod S. Javadi
Bruno Märkl
Christoph Aulmann
Andreas K. Buck
Martin Fassnacht
Constantin Lapa
Michael C. Kreissl
eng
uncontrolled
18F-FDG
eng
uncontrolled
vandetanib
eng
uncontrolled
TKI
eng
uncontrolled
PET
eng
uncontrolled
positron emission tomography
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Medizinische Klinik und Poliklinik I
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16114/Werner_Rudolf_Vandetanib_Kongressbeitrag_accepted_version.pdf
16116
2017
eng
247
No. Supplement 1
58
conferenceobject
Society of Nuclear Medicine and Molecular Imaging
1
2018-04-25
--
--
Less is sometimes more – Accurate Dose Mapping after Endoradiotherapy with \(^{177}\)Lu-DOTATATE/-TOC by One-Single Measurement after 96 h
No abstract available.
Journal of Nuclear Medicine
0161-5505
http://jnm.snmjournals.org/content/58/supplement_1/247.abstract
urn:nbn:de:bvb:20-opus-161168
This research was originally published in JNM. Werner R.A., Lapa C., Buck A.K., Lassmann M., Hänscheid H.Less is sometimes more – Accurate Dose Mapping after Endoradiotherapy with 177Lu-DOTATATE/-TOC by One-Single Measurement after 96 h. J Nucl Med May 1, 2017 vol. 58 no. supplement 1:247. © SNMMI
Johns Hopkins School of Medicine, Baltimore, MD, U.S.
701983
Journal of Nuclear Medicine May 1, 2017 vol. 58 no. supplement 1:247. © SNMMI.
Deutsches Urheberrecht
Rudolf Werner
Constantin Lapa
Andreas Buck
Michael Lassmann
Heribert Hänscheid
eng
uncontrolled
Neuroendocrine Tumor
eng
uncontrolled
theranostics
eng
uncontrolled
177Lu-DOTATATE
eng
uncontrolled
177Lu-DOTATOC
eng
uncontrolled
PRRT
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16116/Werner_Rudolf_Theranostics_Kongressbeitrag_accepted_version.pdf