TY  - JOUR
A1  - Giansanti, Manuela
A1  - Theinert, Tobias
A1  - Boeing, Sarah Katharina
A1  - Haas, Dorothee
A1  - Schlegel, Paul-Gerhardt
A1  - Vacca, Paola
A1  - Nazio, Francesca
A1  - Caruana, Ignazio
T1  - Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
JF  - Molecular Cancer
N2  - Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to viral infection, playing a key role in human health and disease. At present, a growing number of evidence suggests a role of autophagy as a primitive innate immune form of defense for eukaryotic cells, interacting with components of innate immune signaling pathways and regulating thymic selection, antigen presentation, cytokine production and T/NK cell homeostasis. In cancer, autophagy is intimately involved in the immunological control of tumor progression and response to therapy. However, very little is known about the role and impact of autophagy in T and NK cells, the main players in the active fight against infections and tumors. Important questions are emerging: what role does autophagy play on T/NK cells? Could its modulation lead to any advantages? Could specific targeting of autophagy on tumor cells (blocking) and T/NK cells (activation) be a new intervention strategy? In this review, we debate preclinical studies that have identified autophagy as a key regulator of immune responses by modulating the functions of different immune cells and discuss the redundancy or diversity among the subpopulations of both T and NK cells in physiologic context and in cancer.
KW  - autophagy
KW  - effector cells
KW  - mitophagy
KW  - metabolism
KW  - T and NK development
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-357515
VL  - 22
ER  -