TY  - JOUR
A1  - Freitag‐Wolf, Sandra
A1  - Munz, Matthias
A1  - Junge, Olaf
A1  - Graetz, Christian
A1  - Jockel‐Schneider, Yvonne
A1  - Staufenbiel, Ingmar
A1  - Bruckmann, Corinna
A1  - Lieb, Wolfgang
A1  - Franke, Andre
A1  - Loos, Bruno G.
A1  - Jepsen, Søren
A1  - Dommisch, Henrik
A1  - Schaefer, Arne S.
T1  - Sex‐specific genetic factors affect the risk of early‐onset periodontitis in Europeans
JF  - Journal of Clinical Periodontology
N2  - Aims
Various studies have reported that young European women are more likely to develop early‐onset periodontitis compared to men. A potential explanation for the observed variations in sex and age of disease onset is the natural genetic variation within the autosomal genomes. We hypothesized that genotype‐by‐sex (G × S) interactions contribute to the increased prevalence and severity.
Materials and methods
Using the case‐only design, we tested for differences in genetic effects between men and women in 896 North‐West European early‐onset cases, using imputed genotypes from the OmniExpress genotyping array. Population‐representative 6823 controls were used to verify that the interacting variables G and S were uncorrelated in the general population.
Results
In total, 20 loci indicated G × S associations (P < 0.0005), 3 of which were previously suggested as risk genes for periodontitis (ABLIM2, CDH13, and NELL1). We also found independent G × S interactions of the related gene paralogs MACROD1/FLRT1 (chr11) and MACROD2/FLRT3 (chr20). G × S‐associated SNPs at CPEB4, CDH13, MACROD1, and MECOM were genome‐wide‐associated with heel bone mineral density (CPEB4, MECOM), waist‐to‐hip ratio (CPEB4, MACROD1), and blood pressure (CPEB4, CDH13).
Conclusions
Our results indicate that natural genetic variation affects the different heritability of periodontitis among sexes and suggest genes that contribute to inter‐sex phenotypic variation in early‐onset periodontitis.
KW  - alveolar bone loss
KW  - gene × sex interaction
KW  - genetic risk
KW  - heritability
KW  - inflammation
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-262445
VL  - 48
IS  - 11
SP  - 1404
EP  - 1413
ER  -