TY  - JOUR
A1  - Schlagenhauf, Ulrich
A1  - Jakob, Lena
A1  - Eigenthaler, Martin
A1  - Segerer, Sabine
A1  - Jockel-Schneider, Yvonne
A1  - Rehn, Monika
T1  - Regular consumption of Lactobacillus reuteri-containing lozenges reduces pregnancy gingivitis: an RCT
JF  - Journal of Clinical Periodontology
N2  - Aim: 
This randomized controlled trial assessed the impact of Lactobacillus reuteri on pregnancy gingivitis in healthy women. 

Materials and Methods: 
Forty-five healthy women (24 test/21 placebo) with pregnancy gingivitis in the third trimester of pregnancy were enrolled. At baseline Gingival Index (GI) and Plaque Index (PlI) were assessed at the Ramfjord teeth and venous blood taken for TNF-alpha analysis. Subsequently participants were randomly provided with lozenges to be consumed 2 9 daily until birth (approx. 7 weeks) containing >= 10(8) CFU L. reuteri ATCC PTA 5289 and >= 10(8) CFU L. reuteri DSM 17938 (test) or being devoid of L. reuteri (placebo). Within 2 days after birth recording of GI, PlI and blood sampling were repeated. 

Results: 
At baseline, mean GI and mean PlI did not differ significantly between both groups. In the test group mean TNF-alpha serum level was significantly (p < 0.02) lower than in the placebo group. At reevaluation, mean GI and mean PlI of the test group were both significantly (p < 0.0001) lower than in the placebo group. Mean TNF-alpha serum level did no longer differ significantly between the groups. 

Conclusions: 
The consumption of L. reuteri lozenges may be a useful adjunct in the control of pregnancy gingivitis.
KW  - chronic periodontitis
KW  - probiotic lozenges
KW  - subgingival
KW  - bacteria
KW  - postpartum
KW  - microbiota
KW  - disease
KW  - L. reuteri
KW  - plaque
KW  - pregnancy
KW  - pregnancy gingivitis
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-186783
VL  - 43
IS  - 11
ER  -