TY  - JOUR
A1  - Tumir, Lidija-Marija
A1  - Pavlović Saftić, Dijana
A1  - Crnolatac, Ivo
A1  - Ban, Željka
A1  - Maslać, Matea
A1  - Griesbeck, Stefanie
A1  - Marder, Todd B.
A1  - Piantanida, Ivo
T1  - The nature of the (oligo/hetero)arene linker connecting two triarylborane cations controls fluorimetric and circular dichroism sensing of various ds-DNAs and ds-RNAs
JF  - Molecules
N2  - A series of tetracationic bis-triarylborane dyes, differing in the aromatic linker connecting two dicationic triarylborane moieties, showed very high submicromolar affinities toward ds-DNA and ds-RNA. The linker strongly influenced the emissive properties of triarylborane cations and controlled the fluorimetric response of dyes. The fluorene-analog shows the most selective fluorescence response between AT-DNA, GC-DNA, and AU-RNA, the pyrene-analog’s emission is non-selectively enhanced by all DNA/RNA, and the dithienyl-diketopyrrolopyrrole analog’s emission is strongly quenched upon DNA/RNA binding. The emission properties of the biphenyl-analog were not applicable, but the compound showed specific induced circular dichroism (ICD) signals only for AT-sequence-containing ds-DNAs, whereas the pyrene-analog ICD signals were specific for AT-DNA with respect to GC-DNA, and also recognized AU-RNA by giving a different ICD pattern from that observed upon interaction with AT-DNA. The fluorene- and dithienyl-diketopyrrolopyrrole analogs were ICD-signal silent. Thus, fine-tuning of the aromatic linker properties connecting two triarylborane dications can be used for the dual sensing (fluorimetric and CD) of various ds-DNA/RNA secondary structures, depending on the steric properties of the DNA/RNA grooves.
KW  - triarylborane
KW  - fluorescent probe
KW  - circular dichroism
KW  - DNA recognition
KW  - RNA recognition
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-319322
SN  - 1420-3049
VL  - 28
IS  - 11
ER  -