TY  - JOUR
A1  - Maier, Gerrit S.
A1  - Weissenberger, Manuel
A1  - Rudert, Maximilian
A1  - Roth, Klaus E.
A1  - Horas, Konstantin
T1  - The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology—a narrative overview of the literature
JF  - Annals of Translational Medicine
N2  - Vitamin D is considered to play an important role in musculoskeletal health. It’s classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almost innumerable diseases. Further, it is estimated that more than one billion people globally are affected by insufficient vitamin D levels. As such, research on vitamin D has been particularly popular over the past years. In orthopaedics and traumatology, most studies describe favourable effects of vitamin D in general. However, the relative importance of vitamin D is oftentimes debated. In this narrative review of the literature, we consider first, the properties of vitamin D and how vitamin D, vitamin D deficiency and the vitamin D receptor (VDR) impact on musculoskeletal health. Secondly, we provide an overview of studies reporting the prevalence of vitamin D deficiency in traumatology and diverse orthopaedic diseases including bone oncology. Lastly, we emphasise recent findings and touch on future perspectives in vitamin D research.
KW  - vitamin D
KW  - vitamin D deficiency (VDR)
KW  - orthopaedics
KW  - orthopedics
KW  - traumatology
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-370110
VL  - 9
ER  -