TY  - JOUR
A1  - McNeill, Rhiannon V.
A1  - Radtke, Franziska
A1  - Nieberler, Matthias
A1  - Koreny, Carolin
A1  - Chiocchetti, Andreas G.
A1  - Kittel-Schneider, Sarah
T1  - Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3
JF  - Stem Cell Research
N2  - Single nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility of using magnetic activated cell sorting to allow the unbiased selection of fully reprogrammed iPSCs.
KW  - induced pluripotent stem cells
KW  - ADHD patients
KW  - risk SNP rs1397547
KW  - gene ADGRL3
KW  - iPSCs
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-350099
VL  - 67
ER  -