TY  - JOUR
A1  - Glutsch, Valerie
A1  - Wobser, Marion
A1  - Schilling, Bastian
A1  - Gesierich, Anja
A1  - Goebeler, Matthias
A1  - Kneitz, Hermann
T1  - PRAME expression as helpful immunohistochemical marker in rhabdoid melanoma
JF  - Dermatopathology
N2  - Background: Rhabdoid melanoma is a rare variant of malignant melanoma with characteristic cytomorphologic features. Due to the potential loss of conventional melanocytic markers, histopathologic diagnosis is often challenging. We hypothesize that immunostaining for PReferentially expressed Antigen in MElanoma (PRAME) might have the potential to uncover the melanocytic origin of these dedifferentiated tumors. Methods: Four cases of rhabdoid primary melanomas were assessed by immunohistochemistry for expression of PRAME and conventional melanocytic markers. Immunohistochemical expression patterns were analyzed in the rhabdoid primaries and, if available, associated metastases. Results: All four cases of rhabdoid primary melanomas showed a strong nuclear positivity for PRAME, while the expression of conventional melanocytic markers S100, MART-1, SOX-10 and HMB-45 was variable between the analyzed cases. Conclusions: In summary, we report four cases of rhabdoid primary melanoma with high to intermediate expression of PRAME despite the partial and variable loss of other melanocytic markers. Hence, PRAME might facilitate the recognition of this highly aggressive entity to avoid misdiagnosis due to histopathologic pitfalls.
KW  - PRAME
KW  - rhabdoid differentiation
KW  - rhabdoid melanoma
KW  - immunohistochemistry
KW  - melanocytic markers
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284115
SN  - 2296-3529
VL  - 9
IS  - 2
SP  - 148
EP  - 157
ER  -