TY  - JOUR
A1  - Butt, Elke
A1  - Howard, Cory M.
A1  - Raman, Dayanidhi
T1  - LASP1 in cellular signaling and gene expression: more than just a cytoskeletal regulator
JF  - Cells
N2  - LIM and SH3 protein 1 was originally identified as a structural cytoskeletal protein with scaffolding function. However, recent data suggest additional roles in cell signaling and gene expression, especially in tumor cells. These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosphorylation-dependent interaction between LASP1 and cellular proteins that orchestrate primary tumor progression and metastasis. More specifically, we will describe the role of LASP1 in chemokine receptor, and PI3K/AKT signaling. We outline the nuclear role for LASP1 in terms of epigenetics and transcriptional regulation and modulation of oncogenic mRNA translation. Finally, newly identified roles for the cytoskeletal function of LASP1 next to its known canonical F-actin binding properties are included.
KW  - LASP1
KW  - AKT
KW  - CXCR4
KW  - structure
KW  - cytoskeleton
KW  - phosphorylation
KW  - transcriptional regulation
KW  - epigenetics
KW  - nucleus
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-297447
SN  - 2073-4409
VL  - 11
IS  - 23
ER  -