TY  - JOUR
A1  - Rapa, Shara Francesca
A1  - Di Iorio, Biagio Raffaele
A1  - Campiglia, Pietro
A1  - Heidland, August
A1  - Marzocco, Stefania
T1  - Inflammation and oxidative stress in chronic kidney disease — Potential therapeutic role of minerals, vitamins and plant-derived metabolites
JF  - International Journal of Molecular Sciences
N2  - Chronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia and mineral and bone disorders, as well as enhanced cardiovascular mortality. In addition to conventional therapy with anti-inflammatory and antioxidative agents, growing evidence has indicated that certain minerals, vitamins and plant-derived metabolites exhibit beneficial effects in these disturbances. In the current work, we review the anti-inflammatory and antioxidant properties of various agents which could be of potential benefit in CKD/ESRD. However, the related studies were limited due to small sample sizes and short-term follow-up in many trials. Therefore, studies of several anti-inflammatory and antioxidant agents with long-term follow-ups are necessary.
KW  - chronic kidney disease (CKD)
KW  - inflammation
KW  - oxidative stress
KW  - uremic toxins
KW  - minerals
KW  - vitamins
KW  - plant-derived metabolites
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284998
SN  - 1422-0067
VL  - 21
IS  - 1
ER  -