TY  - JOUR
A1  - Müller-Scholden, Lara
A1  - Kirchhof, Jan
A1  - Morbach, Caroline
A1  - Breunig, Margret
A1  - Meijer, Rudy
A1  - Rücker, Viktoria
A1  - Tiffe, Theresa
A1  - Yurdadogan, Tino
A1  - Wagner, Martin
A1  - Gelbrich, Götz
A1  - Bots, Michiel L.
A1  - Störk, Stefan
A1  - Heuschmann, Peter U.
T1  - Segment-specific association of carotid-intima-media thickness with cardiovascular risk factors – findings from the STAAB cohort study
JF  - BMC Cardiovascular Disorders
N2  - Background
The guideline recommendation to not measure carotid intima-media thickness (CIMT) for cardiovascular risk prediction is based on the assessment of just one single carotid segment. We evaluated whether there is a segment-specific association between different measurement locations of CIMT and cardiovascular risk factors.

Methods
Subjects from the population-based STAAB cohort study comprising subjects aged 30 to 79 years of the general population from Würzburg, Germany, were investigated. CIMT was measured on the far wall of both sides in three different predefined locations: common carotid artery (CCA), bulb, and internal carotid artery (ICA). Diabetes, dyslipidemia, hypertension, smoking, and obesity were considered as risk factors. In multivariable logistic regression analysis, odds ratios of risk factors per location were estimated for the endpoint of individual age- and sex-adjusted 75th percentile of CIMT.

Results
2492 subjects were included in the analysis. Segment-specific CIMT was highest in the bulb, followed by CCA, and lowest in the ICA. Dyslipidemia, hypertension, and smoking were associated with CIMT, but not diabetes and obesity. We observed no relevant segment-specific association between the three different locations and risk factors, except for a possible interaction between smoking and ICA.

Conclusions
As no segment-specific association between cardiovascular risk factors and CIMT became evident, one simple measurement of one location may suffice to assess the cardiovascular risk of an individual.
KW  - Carotid intima-media thickness (CIMT)
KW  - Carotid segment
KW  - Carotid ultrasound
KW  - Cardiovascular risk factors
KW  - Cardiovascular risk prediction
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-200720
VL  - 19
IS  - 84
ER  -