TY  - JOUR
A1  - Luber, Verena
A1  - Lutz, Mathias
A1  - Abele-Horn, Marianne
A1  - Einsele, Hermann
A1  - Grigoleit, Götz Ulrich
A1  - Mielke, Stephan
T1  - Excretion of Ascaris lumbricoides following reduced‐intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole
JF  - Transplant Infectious Disease
N2  - Here, we present the unique case of a 51‐year‐old German patient with multiple myeloma excreting Ascaris lumbricoides in his stool five weeks after allogeneic hematopoietic stem cell transplantation. Stool analysis remained negative for the presence of eggs, and there was no eosinophilia in the peripheral blood at any time around stem cell transplantation. The patient was commenced on a three‐day treatment with mebendazole, which was well tolerated. No serious interactions with the concomitant post‐transplant medication or negative effects on the hematopoiesis were observed, and the myeloma still is in complete remission. To our knowledge, this is the first report on excretion of A lumbricoides in the context of allogeneic stem cell transplantation. The case is remarkable with view to the fact that the parasite has supposedly survived all courses of myeloma treatment including autologous and allogeneic conditioning. Parasitosis with A lumbricoides has a worldwide prevalence of about a billion and is extremely rare in northern Europe. Possibly the patient got infected during a trip to Egypt years before multiple myeloma was diagnosed.
KW  - sirolimus
KW  - mycophenolic acid
KW  - multiple myeloma
KW  - mebendazole
KW  - hematopoietic stem cell transplantation
KW  - Ascaris lumbricoides
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-219608
SN  - 1399-3062
VL  - 22
IS  - 1
ER  - 
TY  - JOUR
A1  - Hansen, Niels
A1  - Seiler, Carola
A1  - Rumpf, Julian
A1  - Kraft, Peter
A1  - Dlaske, Henry
A1  - Abele-Horn, Marianne
A1  - Muellges, Wolfgang
T1  - Human Tuberculous Meningitis Caused by \(Mycobacterium\) \(caprae\)
JF  - Case Reports in Neurology
N2  - INTRODUCTION: Tuberculous meningitis (TM) causes substantial morbidity and mortality in humans. Human TM has been known to be induced by bacteria from the Mycobacterium tuberculosis complex (MTBC), such as M. tuberculosis and M. bovis.
CASE PRESENTATION: We describe a case of meningitis treated with fosfomycin, which showed partial effectiveness in an 80-year-old patient. After a lethal myocardial infarction, M. caprae (MC) was identified in cerebrospinal fluid culture. This isolated acid-fast organism was first identified as MTBC by MTBC-specific PCR (16S rDNA-PCR). Furthermore, species-specific identification of the isolate was done by gyrB PCR-restriction fragment length polymorphism analysis of a part of gyrB DNA. Colony morphology of the isolated MC strain showed dysgonic growth on Lowenstein-Jensen medium. The strain was susceptible to pyrazinamide (PZA).
CONCLUSION: This isolated strain was convincingly identified as MC according to the phenotypic and genotypic characteristics and PZA sensitivity. This is the first report of MC causing TM.
KW  - Mycobacterium caprae
KW  - Mycobacterium caprae
KW  - fosfomycin
KW  - Tuberkulose
KW  - Mycobacterium tuberculosis complex
KW  - tuberculous meningitis
KW  - cerebrospinal fluid culture
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-123425
VL  - 4
IS  - 1
ER  -