TY  - JOUR
A1  - Müller, J. G.
A1  - Krenn, V.
A1  - Schindler, C.
A1  - Czub, S.
A1  - Stahl-Henning, C.
A1  - Coulibaly, C.
A1  - Hunsmann, G.
A1  - Kneitz, C.
A1  - Kerkau, T.
A1  - Rethwilm, A.
A1  - ter Meulen, V.
A1  - Müller-Hermelink, H. K.
T1  - Alterations of Thymus Cortical Epithelium and Interdigitating Dendritic Cells but No Increase of Thymocyte Cell Death in the Early Course of Simian Immunodeficiency Virus Infection
JF  - American Journal of Pathology
N2  - The role of the thymus in the pathogenesis of simian acquired immunodeficiency syndrome was investigated in 18 juvenile rhesus monkeys (Macaca mulatta). The thymus was infected from the first week post-SIVmac inoculation, but the amount of virus-positive cells was very low « 1 in 1 04 T cells) as demonstrated by polymerase chain reaction and in situ hybridization. First morphological alteration was a narrowing of the cortex at 12 and 24 wpi. Morphometry revealed no increase of pyknotic T cells but a decrease of the proliferation rate andflow cytometry showed a reduction of the immature \(CD4^+/CD8^+\) double-positive T cells. Ultrastructural analysis revealed vacuolization, shrinkage, andfinally cytolysis of the cortical epithelial cells and the interdigitating dendritic cells. Immunofluorescence staining exhibited a widespread loss of cortical epithelial cells. This damage to the thymic microenvironment could explain the breakdown of the intrathymic T cell proliferation. It preceded fully developed simian acquired immunodeficiency syndrome and is therefore considered to play a major role in its pathogenesis.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128250
VL  - 143
IS  - 3
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Sibylle
A1  - Liebert, UG
A1  - Baczko, K,
A1  - ter Meulen, V.
T1  - Molecular Biological Analysis of Measles Virus Gene Expression in the CNS of Acutely and Persistently Infected Rat Brain Cells
KW  - Virologie
Y1  - 1988
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-81784
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Sibylle
A1  - Liebert, UG
A1  - Baczko, K.
A1  - ter Meulen, V.
T1  - Molecular Biological Aspects of Virus-Induced Subacute Encephalomyelitis in Lewis Rats
N2  - no abstract available
KW  - Biologie
Y1  - 1988
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-81776
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Sibylle
A1  - Schneider-Schaulies, Jürgen
A1  - Schuster, A.
A1  - Bayer, M.
A1  - Pavlovic, J.
A1  - ter Meulen, V.
T1  - Cell type specific MxA-mediated inhibition of measles virus transcription in human brain cells
N2  - No abstract available
KW  - Virologie
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62255
ER  - 
TY  - JOUR
A1  - Segev, Y.
A1  - Rager-Zisman, B.
A1  - Isakov, N.
A1  - Schneider-Schaulies, Sibylle
A1  - ter Meulen, V.
A1  - Udem, S. A.
A1  - Segal, S.
A1  - Wolfson, M.
T1  - Reversal of measles virus mediated increase of phosphorylating activity in persistently infected mouse neuroblastoma cells by anti measles antibodies
N2  - No abstract available
KW  - Virologie
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62362
ER  - 
TY  - JOUR
A1  - Schnorr, J. J.
A1  - Schneider-Schaulies, Sibylle
A1  - Simon-Jödicke, A.
A1  - Pavlovic, J.
A1  - Horisberger, M. A.
A1  - ter Meulen, V.
T1  - MxA dependent inhibition of Measles Virus glycoprotein synthesis in a stably transfected human monocytic cell line
N2  - No abstract available
KW  - Virologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62353
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Sibylle
A1  - Liebert, U. G.
A1  - Rager-Zisman, B.
A1  - Wolfson, M.
A1  - ter Meulen, V.
T1  - Antibody-dependent transcriptional regulation of measles virus in persistently infected neural cells
N2  - No abstract available
KW  - Virologie
Y1  - 1992
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62329
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Sibylle
A1  - Kreth, H. W.
A1  - Hofmann, G.
A1  - Billeter, M. A.
A1  - ter Meulen, V.
T1  - Expression of measles virus RNA in peripheral blood mononuclear cells of patients with measles, SSPE, and autoimmune diseases
N2  - No abstract available
KW  - Virologie
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62297
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Sibylle
A1  - Liebert, U. G.
A1  - Baczko, K.
A1  - ter Meulen, V.
T1  - Restricted expression of measles virus in primary rat astroglial cells
N2  - No abstract available
KW  - Virologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62283
ER  - 
TY  - JOUR
A1  - Liebert, U. G.
A1  - Schneider-Schaulies, Sibylle
A1  - Baczko, K.
A1  - ter Meulen, V.
T1  - Antibody-induced restriction of viral gene expression in measles encephalitis in rats
N2  - No abstract available
KW  - Virologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62271
ER  -