TY  - JOUR
A1  - Griebsch, Nora-Isabell
A1  - Kern, Johanna
A1  - Hansen, Jonas
A1  - Rullmann, Michael
A1  - Luthardt, Julia
A1  - Helfmeyer, Stephanie
A1  - Dekorsy, Franziska J.
A1  - Soeder, Marvin
A1  - Hankir, Mohammed K.
A1  - Zientek, Franziska
A1  - Becker, Georg-Alexander
A1  - Patt, Marianne
A1  - Meyer, Philipp M.
A1  - Dietrich, Arne
A1  - Blüher, Matthias
A1  - Ding, Yu-Shin
A1  - Hilbert, Anja
A1  - Sabri, Osama
A1  - Hesse, Swen
T1  - Central serotonin/noradrenaline transporter availability and treatment success in patients with obesity
JF  - Brain Sciences
N2  - Serotonin (5-hydroxytryptamine, 5-HT) as well as noradrenaline (NA) are key modulators of various fundamental brain functions including the control of appetite. While manipulations that alter brain serotoninergic signaling clearly affect body weight, studies implicating 5-HT transporters and NA transporters (5-HTT and NAT, respectively) as a main drug treatment target for human obesity have not been conclusive. The aim of this positron emission tomography (PET) study was to investigate how these central transporters are associated with changes of body weight after 6 months of dietary intervention or Roux-en-Y gastric bypass (RYGB) surgery in order to assess whether 5-HTT as well as NAT availability can predict weight loss and consequently treatment success. The study population consisted of two study cohorts using either the 5-HTT-selective radiotracer [\(^{11}\)C]DASB to measure 5-HTT availability or the NAT-selective radiotracer [\(^{11}\)C]MRB to assess NAT availability. Each group included non-obesity healthy participants, patients with severe obesity (body mass index, BMI, >35 kg/m\(^2\)) following a conservative dietary program (diet) and patients undergoing RYGB surgery within a 6-month follow-up. Overall, changes in BMI were not associated with changes of both 5-HTT and NAT availability, while 5-HTT availability in the dorsal raphe nucleus (DRN) prior to intervention was associated with substantial BMI reduction after RYGB surgery and inversely related with modest BMI reduction after diet. Taken together, the data of our study indicate that 5-HTT and NAT are involved in the pathomechanism of obesity and have the potential to serve as predictors of treatment outcomes.
KW  - obesity
KW  - serotonin
KW  - noradrenaline
KW  - serotonin transporter
KW  - noradrenaline transporter
KW  - Roux-en-Y gastric bypass surgery
KW  - body mass index (BMI; kg/m\(^2\))
KW  - radiotracer
KW  - PET
KW  - PET imaging
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-290294
SN  - 2076-3425
VL  - 12
IS  - 11
ER  - 
TY  - JOUR
A1  - Chen, Xinyu
A1  - Werner, Rudolf A.
A1  - Javadi, Mehrbod S.
A1  - Maya, Yoshifumi
A1  - Decker, Michael
A1  - Lapa, Constantin
A1  - Herrmann, Ken
A1  - Higuchi, Takahiro
T1  - Radionuclide imaging of neurohormonal system of the heart
JF  - Theranostics
N2  - Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included.
KW  - SPECT
KW  - radiotracer
KW  - heart failure
KW  - cardiac neurohormonal system
KW  - nuclear cardiology
KW  - PET
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-149205
VL  - 5
IS  - 6
ER  -