TY  - JOUR
A1  - Petritsch, Bernhard
A1  - Köstler, Herbert
A1  - Gassenmaier, Tobias
A1  - Kunz, Andreas S
A1  - Bley, Thorsten A
A1  - Horn, Michael
T1  - An investigation into potential gender-specific differences in myocardial triglyceride content assessed by \(^{1}\)H-Magnetic Resonance Spectroscopy at 3Tesla
JF  - Journal of International Medical Research
N2  - Objective:
Over the past decade, myocardial triglyceride content has become an accepted biomarker for chronic metabolic and cardiac disease. The purpose of this study was to use proton (hydrogen 1)-magnetic resonance spectroscopy (\(^{1}\)H-MRS) at 3Tesla (3 T) field strength to assess potential gender-related differences in myocardial triglyceride content in healthy individuals.

Methods:
Cardiac MR imaging was performed to enable accurate voxel placement and obtain functional and morphological information. Double triggered (i.e., ECG and respiratory motion gating) \(^{1}\)H-MRS was used to quantify myocardial triglyceride levels for each gender. Two-sample t-test and Mann-Whitney U-test were used for statistical analyses.

Results:
In total, 40 healthy volunteers (22 male, 18 female; aged >18 years and age matched) were included in the study. Median myocardial triglyceride content was 0.28% (interquartile range [IQR] 0.17–0.42%) in male and 0.24% (IQR 0.14–0.45%) in female participants, and no statistically significant difference was observed between the genders. Furthermore, no gender-specific difference in ejection fraction was observed, although on average, male participants presented with a higher mean ± SD left ventricular mass (136.3 ± 25.2 g) than female participants (103.9 ± 16.1 g).

Conclusions:
The study showed that \(^{1}\)H-MRS is a capable, noninvasive tool for acquisition of myocardial triglyceride metabolites. Myocardial triglyceride concentration was shown to be unrelated to gender in this group of healthy volunteers.
KW  - cardiac
KW  - magnetic resonance imaging
KW  - 1H-Magnetic resonance spectroscopy (1H-MRS)
KW  - myocardium
KW  - triglycerides
KW  - metabolism
KW  - gender
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-168808
VL  - 44
IS  - 3
ER  - 
TY  - THES
A1  - Machann, Wolfram
T1  - MRT nach Myokardinfarkt - Wandfunktionsanalyse und metabolische Bildgebung
T1  - MRI after myocardial infarction - Wall motion analysis and metabolic imaging
N2  - Die kardiale MRT konnte in dieser Arbeit für die Infarktdiagnostik und Therapiekontrolle erfolgreich eingesetzt werden. Auf Grund einer Vielzahl von Sequenztechniken, dem Vorteil der Nichtinvasivität und dem Fehlen von ionisierenden Strahlen hat sich die MRT zu einem wichtigen Diagnostikwerkzeug zur Bestimmung von Prognoseparametern bei kardialen Erkrankungen entwickelt.
N2  - Cardiac MRI could be used successfully for the diagnosis of myocardial infarction and for therapy control. Due to a multiplicity of MRI sequences, the advantage of a non invasive approach and the lack of ionising rays, MRI developed to an important diagnostic tool for the determination of parameters in cardiac diseases
KW  - NMR-Tomographie
KW  - Herz
KW  - Natrium
KW  - MRI
KW  - cardiac
KW  - sodium
Y1  - 2008
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-28457
ER  -