TY  - JOUR
A1  - Tacke, Reinhold
A1  - Bentlagem, A.
A1  - Towart, R.
A1  - Meyer, H.
A1  - Bossert, F.
A1  - Vater, W.
A1  - Stoepe, K.
T1  - Sila-Analoga von Nifedipin-ähnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin-3.5-dicarbonsäure-dialkylestern, I
N2  - no abstract available
KW  - Chemie
Y1  - 1980
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82430
ER  - 
TY  - JOUR
A1  - Tacke, R.
A1  - Bentlage, A.
A1  - Sheldrick, W. S.
A1  - Ernst, L.
A1  - Towart, R.
A1  - Stoepel, K.
T1  - Sila-Pharmaka, 24. Mitt. [1]. Sila-Analoga von Nifedipin-ähnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin- 3.5-dicarbonsäure-dialkylestern, II.
T1  - Sila-Drugs, 24th Communication [1]. Sila-Analogues of Nifedipine-Like Dialkyl 4-Aryl-2,6-dimethyl-1,4-dihydropyridine- 3,5-dicarboxylates, II.
JF  - Zeitschrift für Naturforschung B
N2  - In the course of systematic studies on sila-substituted drugs the nifedipine-like 1.4-dihydropyridine derivatives 4a, 4b and 4c were prepared and investigated with respect to sila-substitution effects. By X-ray diffraction analyses 4a, 4b and 4c were found to be isostructural. The C/Si-analogues exhibit similar spasmolytic activities (in vitro, guinea pig ileum), comparable with that of nifedipine. However, the compounds differ substantially in their in vivo activity, as measured by the antihypertensive effect on the renal-hypertensive rat. The experimental results are discussed with respect to the carbon/silicon exchange.
KW  - sila-analogues of Nifedipine derivatives
KW  - X-ray
KW  - pharmacological activity
KW  - structure-activity relationships
Y1  - 1982
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128381
VL  - 37
IS  - 4
ER  -