TY  - JOUR
A1  - Ferianec, Vladimír
A1  - Fülöp, Matej
A1  - Ježovičová, Miriam
A1  - Radošinská, Jana
A1  - Husseinová, Marta
A1  - Feriancová, Michaela
A1  - Radošinská, Dominika
A1  - Barančík, Miroslav
A1  - Muchová, Jana
A1  - Hȍgger, Petra
A1  - Ďuračková, Zdeňka
T1  - The oak−wood extract Robuvit\(^®\) improves recovery and oxidative stress after hysterectomy: a randomized, double-blind, placebo-controlled pilot study
JF  - Nutrients
N2  - Hysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (Quercus robur) containing at least 40% polyphenols of the ellagitannins class, Robuvit\(^®\), on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. The supplementation with Robuvit\(^®\) (300 mg/day) during 4 weeks significantly improved general and mental health, while under placebo some items significantly deteriorated. Oxidative stress and enhancement of MMP–9 activity was significantly reduced by Robuvit\(^®\) versus placebo. After 8 weeks of intervention, the patients’ condition improved independently of the intervention. Our results suggest that the use of Robuvit\(^®\) as a natural supplement relieves post-operative symptoms of patients after hysterectomy and reduces oxidative stress. The study was registered with ID ISRCTN 11457040 (13/09/2019).
KW  - hysterectomy
KW  - Robuvit\(^®\)
KW  - oak wood extract
KW  - post-operative recovery
KW  - oxidative stress
KW  - matrix metalloproteinases
KW  - complementary medicine
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-203265
SN  - 2072-6643
VL  - 12
IS  - 4
ER  -