TY  - JOUR
A1  - Meyer, Malin Tordis
A1  - Watermann, Christoph
A1  - Dreyer, Thomas
A1  - Wagner, Steffen
A1  - Wittekindt, Claus
A1  - Klussmann, Jens Peter
A1  - Ergün, Süleyman
A1  - Baumgart-Vogt, Eveline
A1  - Karnati, Srikanth
T1  - Differential expression of peroxisomal proteins in distinct types of parotid gland tumors
JF  - International Journal of Molecular Sciences
N2  - Salivary gland cancers are rare but aggressive tumors that have poor prognosis and lack effective cure. Of those, parotid tumors constitute the majority. Functioning as metabolic machinery contributing to cellular redox balance, peroxisomes have emerged as crucial players in tumorigenesis. Studies on murine and human cells have examined the role of peroxisomes in carcinogenesis with conflicting results. These studies either examined the consequences of altered peroxisomal proliferators or compared their expression in healthy and neoplastic tissues. None, however, examined such differences exclusively in human parotid tissue or extended comparison to peroxisomal proteins and their associated gene expressions. Therefore, we examined differences in peroxisomal dynamics in parotid tumors of different morphologies. Using immunofluorescence and quantitative PCR, we compared the expression levels of key peroxisomal enzymes and proliferators in healthy and neoplastic parotid tissue samples. Three parotid tumor subtypes were examined: pleomorphic adenoma, mucoepidermoid carcinoma and acinic cell carcinoma. We observed higher expression of peroxisomal matrix proteins in neoplastic samples with exceptional down regulation of certain enzymes; however, the degree of expression varied between tumor subtypes. Our findings confirm previous experimental results on other organ tissues and suggest peroxisomes as possible therapeutic targets or markers in all or certain subtypes of parotid neoplasms.
KW  - peroxisomes
KW  - parotid gland
KW  - salivary
KW  - tumors
KW  - pleomorphic adenoma
KW  - mucoepidermoid carcinoma
KW  - acinic cell carcinoma
KW  - differential expression
KW  - immunohistochemistry
KW  - mRNA
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-261047
SN  - 1422-0067
VL  - 22
IS  - 15
ER  -