TY  - JOUR
A1  - Rushdi, Mohammed I.
A1  - Abdel-Rahman, Iman A. M.
A1  - Attia, Eman Zekry
A1  - Saber, Hani
A1  - Saber, Abdullah A.
A1  - Bringmann, Gerhard
A1  - Abdelmohsen, Usama Ramadan
T1  - The biodiversity of the genus Dictyota: phytochemical and pharmacological natural products prospectives
JF  - Molecules
N2  - Although a broad variety of classes of bioactive compounds have already been isolated from seaweeds of the genus Dictyota, most different species are still chemically and biologically unexplored. Dictyota species are well-known brown seaweeds belonging to the Dictyotaceae (Phaeophyta). The phytochemical composition within the genus Dictyota has recently received considerable interest, and a vast array of components, including diterpenes, sesquiterepenes, sterols, amino acids, as well as saturated and polyunsaturated fatty acids, have been characterized. The contribution of these valued metabolites to the biological potential, which includes anti-proliferative, anti-microbial, antiviral, antioxidant, anti-inflammatory, and anti-hyperpigmentation activities, of the genus Dictyota has also been explored. Therefore, this is the most comprehensive review, focusing on the published literature relevant to the chemically and pharmacologically diverse biopharmaceuticals isolated from different species of the genus Dictyota during the period from 1976 to now.
KW  - Phaeophyceae
KW  - Dictyotaceae
KW  - marine macroalgae
KW  - brown seaweeds
KW  - natural products
KW  - bioactivities
KW  - Dictyota
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-302428
SN  - 1420-3049
VL  - 27
IS  - 3
ER  - 
TY  - JOUR
A1  - Dashti, Yousef
A1  - Grkovic, Tanja
A1  - Abdelmohsen, Usama Ramadan
A1  - Hentschel, Ute
A1  - Quinn, Ronald J.
T1  - Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp EG49 and Nocardiopsis sp RV163
JF  - MARINE DRUGS
N2  - Two sponge-derived actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163, were grown in co-culture and the presence of induced metabolites monitored by H-1 NMR. Ten known compounds, including angucycline, diketopiperazine and beta-carboline derivatives 1-10, were isolated from the EtOAc extracts of Actinokineospora sp. EG49 and Nocardiopsis sp. RV163. Co-cultivation of Actinokineospora sp. EG49 and Nocardiopsis sp. RV163 induced the biosynthesis of three natural products that were not detected in the single culture of either microorganism, namely N-(2-hydroxyphenyl)-acetamide (11), 1,6-dihydroxyphenazine (12) and 5a, 6,11a, 12-tetrahydro-5a, 11a-dimethyl[1,4]benzoxazino[3,2-b][1,4]benzoxazine (13a). When tested for biological activity against a range of bacteria and parasites, only the phenazine 12 was active against Bacillus sp. P25, Trypanosoma brucei and interestingly, against Actinokineospora sp. EG49. These findings highlight the co-cultivation approach as an effective strategy to access the bioactive secondary metabolites hidden in the genomes of marine actinomycetes.
KW  - co-cultivation
KW  - induced metabolites
KW  - sponge-associated actinomyetes
KW  - NMR fingerprint
KW  - bioactivity
KW  - natural products
KW  - A-D
KW  - aspergillus fumigatus
KW  - marine
KW  - biosynthesis
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-116547
SN  - 1660-3397
VL  - 12
IS  - 5
ER  -