TY  - JOUR
A1  - Preiser, J. C.
A1  - Schmartz, D.
A1  - Van der Linden, P.
A1  - Content, J.
A1  - Vanden Bussche, P.
A1  - Buurman, W.
A1  - Sebald, Werner
A1  - Dupont, E.
A1  - Pinsky, M. R.
A1  - Vincent, J. L.
T1  - Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog
N2  - To investigate the possible hemodynamic efl'ects of interleukin-6 (IL-6), a single dose of 15 mcg/kg of recombinant IL-6 isolated from Escherichia coli was injected intravenously in six pentobarbital-anesthetized dogs. After 30 min, saline infusion was performed to maintain the - pulmonary artery balloon-occluded pressure at baseline Ievel. The animals were observed for up to 5 hours. No other hemodynamic alteration was observed than a gradual decline in cardiac output attributed to anesthesia. Hematologic variables, blood glucose, and total serum proteins were also constant. IL-6 levels were markedly elevated in the blood, bot no tumor necrosis factor activity was detected. Thus a primary role for IL-6 in the early cardiovascular alterations associated with septic shock seems unlikely.
KW  - Biochemie
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62511
ER  -