TY  - JOUR
A1  - Montoya Peláez, Guillermo L.
A1  - Sierra, Jelver A.
A1  - Alzate, Fernando
A1  - Holzgrabe, Ulrike
A1  - Ramirez-Pineda, José R.
T1  - Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
JF  - Revista Brasileira de Farmacognosia - Brazilian Journal of Pharmacognosy
N2  - Pentacyclic triterpenes are a large family of plant metabolites that exhibit a wide array of biological activities. The genus Cecropia, which encompasses many plant species, has been used as traditional medicine for the treatment of inflammatory diseases and is known to produce many active pentacyclic triterpenes. In this study we investigated the chemical composition of a pentacyclic triterpene fraction from the roots of Cecropia telenitida Cuatrec., Urticaceae. A novel compound, which we termed yarumic acid, and four known molecules (serjanic acid, spergulagenic acid A, 20-hydroxy-ursolic acid and goreishic acid I) were isolated and characterised. In a dendritic cell (DC)-based assay, we demonstrated that non-toxic doses of these pentacyclic triterpenes inhibited the secretion of at least one of the proinflammatory cytokines tested (IL-1 beta, IL-12p40, IL-12p70, TNF-alpha). Spergulagenic acid A also inhibited nitric oxide production in lipopolysaccharide-stimulated dendritic cell. Serjanic acid and spergulagenic acid A, which were the most potent abundant compounds in the pentacyclic triterpene fraction, showed the most activity in the dendritic cell-based assay. These results show that all pentacyclic triterpenes might contribute to the anti-inflammatory activities of C. telenitida. Moreover, yarumic acid as well as the four known pentacyclic triterpenes, can be exploited as potential immunomodulatory/anti-inflammatory agents.
KW  - psidium guajava;
KW  - oleanane saponins
KW  - kappa-B activation
KW  - cytokine production
KW  - chenopodium quinoa
KW  - obtusifolia bertol
KW  - nitric oxide
KW  - ursolic acid
KW  - bone marrow
KW  - macrophages
KW  - pentacyclic triterpene
KW  - dendritic cells
KW  - anti-inflammatory activity
KW  - cytokine modulation
KW  - natural product
KW  - cecropia telenitida
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-131851
VL  - 23
ER  -