TY  - JOUR
A1  - Glaser, Jan
A1  - Schurigt, Uta
A1  - Suzuki, Brian M.
A1  - Caffrey, Connor R.
A1  - Holzgrabe, Ulrike
T1  - Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl
JF  - Molecules
N2  - Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula of Schistosoma (S.) mansoni. Compound 1 did not show any anti-schistosomal activity. However, strong phenotypic changes, including the formation of vacuoles, degeneration and death were observed after in vitro treatment with compounds 23 (thymyl cinnamate) and 27 (eugenyl cinnamate). Electron microscopy analysis of the induced vacuoles in the dying parasites suggests that 23 and 27 interfere with autophagy.
KW  - thymyl cinnamate
KW  - vacuoles
KW  - autophagy
KW  - anti-schistosomal activity
KW  - schistosoma
KW  - schistosomula
KW  - parasite
KW  - eugenyl cinnamate
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-125712
VL  - 20
ER  -