TY  - JOUR
A1  - Gessler, Manfred
A1  - Thomas, G. H.
A1  - Couillin, P.
A1  - Junien, C.
A1  - McGillivray, B. C.
A1  - Hayden, M.
A1  - Jaschek, G.
A1  - Bruns, G. A.
T1  - A deletion map of the WAGR region on chromosome II
N2  - The WAGR (Wilms tumor, aniridia, genitourinary anomalies, and mental retardation) region has been assigned to chromosome 11p13 on the basis of overlapping constitutional deletions found in affected individuals. We have utilized 31 DNA probes which map to the WAGR deletion region, together with six reference loci and 13 WAGR-related deletions, to subdivide this area into 16 intervals. Specific intervals have been correlated with phenotypic features, leading to the identification of individual subregions for the aniridia and Wilms tumor loci. Delineation, by specific probes, of multiple intervals above and below the critical region and of five intervals within the overlap area provides a framework map for molecular characterization of WAGR gene loci and of deletion boundary regions.
KW  - Biochemie
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59255
ER  - 
TY  - JOUR
A1  - van Heyningen, V.
A1  - Bickmore, W. A.
A1  - Seawright, A.
A1  - Fletcher, J. M.
A1  - Maule, J.
A1  - Fekete, G.
A1  - Gessler, Manfred
A1  - Bruns, G. A.
A1  - Huerre-Jeanpierre, C.
A1  - Junien, C.
T1  - Role for the Wilms tumor gene in genital development?
N2  - No abstract available
KW  - Biochemie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59238
ER  - 
TY  - JOUR
A1  - Gessler, Manfred
A1  - Hameister, H.
A1  - Henry, I.
A1  - Junien, C.
A1  - Braun, T.
A1  - Arnold, H. H.
T1  - The human MyoD1 (MYF3) gene maps on the short arm of chromosome 11 but is not associated with the WAGR locus or the region for the Beckwith-Wiedemann syndrome
N2  - The human gene encoding the myogenic determination factor myf3 (mouse MyoD1) has been mapped to the short arm of chromosome 11. Analysis of several somatic cell hybrids containing various derivatives with deletions or translocations revealed that the human MyoD (MYF3) gene is not associated with the WAGR locus at chromosomal band 11pl3 nor with the loss of the heterozygosity region at 11p15.5 related to the Beckwith-Wiedemann syndrome. Subregional mapping by in situ hybridization with an myf3 specific probe shows that the gene resides at the chromosomal band llp14, possibly at llp14.3.
KW  - Biochemie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59221
ER  -