TY  - JOUR
A1  - Baune, Bernhard T.
A1  - Konrad, Carsten
A1  - Grotegerd, Dominik
A1  - Suslow, Thomas
A1  - Birosova, Eva
A1  - Ohrmann, Patricia
A1  - Bauer, Jochen
A1  - Arolt, Volker
A1  - Heindel, Walter
A1  - Domschke, Katharina
A1  - Schöning, Sonja
A1  - Rauch, Astrid V.
A1  - Uhlmann, Christina
A1  - Kugel, Harald
A1  - Dannlowski, Udo
T1  - Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain
JF  - Journal of Neuroinflammation
N2  - Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes. In this study the potential dual role of several IL-6 polymorphisms in brain morphology is investigated. 
Methodology: In a large sample of healthy individuals (N = 303), associations between genetic variants of IL-6 (rs1800795; rs1800796, rs2069833, rs2069840) and brain volume (gray matter volume) were analyzed using voxel-based morphometry (VBM). Selection of single nucleotide polymorphisms (SNPs) followed a tagging SNP approach (e. g., Stampa algorigthm), yielding a capture 97.08% of the variation in the IL-6 gene using four tagging SNPs. Principal findings/results In a whole-brain analysis, the polymorphism rs1800795 (-174 C/G) showed a strong main effect of genotype (43 CC vs. 150 CG vs. 100 GG; x = 24, y = -10, z = -15; F(2,286) = 8.54, p(uncorrected) = 0.0002; p(AlphaSim-corrected) = 0.002; cluster size k = 577) within the right hippocampus head. Homozygous carriers of the G-allele had significantly larger hippocampus gray matter volumes compared to heterozygous subjects. None of the other investigated SNPs showed a significant association with grey matter volume in whole-brain analyses. 
Conclusions/significance: These findings suggest a possible neuroprotective role of the G-allele of the SNP rs1800795 on hippocampal volumes. Studies on the role of this SNP in psychiatric populations and especially in those with an affected hippocampus (e.g., by maltreatment, stress) are warranted.
KW  - aging brain
KW  - hippocampal neurogenesis
KW  - cholinergic neurons
KW  - neurothrophic factor
KW  - Alzheimers disease
KW  - neurite outgrowth
KW  - inflammatory cytokines
KW  - major depression
KW  - nervour system
KW  - dentate gyrus
KW  - genetics
KW  - inflammation
KW  - interleukin 6
KW  - neuroprotection
KW  - voxel-based morphometry
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-130804
VL  - 9
IS  - 125
ER  - 
TY  - JOUR
A1  - Werner, Rudolf
A1  - Wakabayashi, Hiroshi
A1  - Bauer, Jochen
A1  - Schütz, Claudia
A1  - Zechmeister, Christina
A1  - Hayakawa, Nobuyuki
A1  - Javadi, Mehrbod S.
A1  - Lapa, Constantin
A1  - Jahns, Roland
A1  - Ergün, Süleyman
A1  - Jahns, Valerie
A1  - Higuchi, Takahiro
T1  - Longitudinal \(^{18}\)F-FDG PET imaging in a Rat Model of Autoimmune Myocarditis
JF  - European Heart Journal Cardiovascular Imaging
N2  - Aims: Although mortality rate is very high, diagnosis of acute myocarditis remains challenging with conventional tests. We aimed to elucidate the potential role of longitudinal 2-Deoxy-2-\(^{18}\)F-fluoro-D-glucose (\(^{18}\)F-FDG) positron emission tomography (PET) inflammation monitoring in a rat model of experimental autoimmune myocarditis.

Methods and results: Autoimmune myocarditis was induced in Lewis rats by immunizing with porcine cardiac myosin emulsified in complete Freund’s adjuvant. Time course of disease was assessed by longitudinal \(^{18}\)F-FDG PET imaging. A correlative analysis between in- and ex vivo \(^{18}\)F-FDG signalling and macrophage infiltration using CD68 staining was conducted. Finally, immunohistochemistry analysis of the cell-adhesion markers CD34 and CD44 was performed at different disease stages determined by longitudinal \(^{18}\)F-FDG PET imaging. After immunization, myocarditis rats revealed a temporal increase in 18F-FDG uptake (peaked at week 3), which was followed by a rapid decline thereafter. Localization of CD68 positive cells was well correlated with in vivo \(^{18}\)F-FDG PET signalling (R\(^2\) = 0.92) as well as with ex vivo 18F-FDG autoradiography (R\(^2\) = 0.9, P < 0.001, respectively). CD44 positivity was primarily observed at tissue samples obtained at acute phase (i.e. at peak 18F-FDG uptake), while CD34-positive staining areas were predominantly identified in samples harvested at both sub-acute and chronic phases (i.e. at \(^{18}\)F-FDG decrease).

Conclusion: \(^{18}\)F-FDG PET imaging can provide non-invasive serial monitoring of cardiac inflammation in a rat model of acute myocarditis.
KW  - positron emission tomography
KW  - Myokarditis
KW  - myocarditis
KW  - inflammation
KW  - 18F-FDG
KW  - PET
KW  - personalized treatment
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-165601
SN  - 2047-2404
ER  -