TY  - JOUR
A1  - Gaiser, Timo
A1  - Geissinger, Eva
A1  - Schattenberg, Torsten
A1  - Scharf, Hanns-Peter
A1  - Dürken, Matthias
A1  - Dinter, Dietmar
A1  - Rosenwald, Andreas
A1  - Marx, Alexander
T1  - Case report: a unique pediatric case of a primary CD8 expressing ALK-1 positive anaplastic large cell lymphoma of skeletal muscle
JF  - Diagnostic Pathology
N2  - Primary involvement of skeletal muscle is a very rare event in ALK-1 positive anaplastic large cell lymphoma (ALCL). We describe a case of a 10-year old boy presenting with a three week history of pain and a palpable firm swelling at the dorsal aspect of the left thigh. Histological examination of the lesion revealed a tumoral and diffuse polymorphic infiltration of the muscle by large lymphoid cells. Tumor cells displayed eccentric, lobulated "horse shoe" or "kidney-shape" nuclei. The cells showed immunohistochemical positivity for CD30, ALK-1, CD2, CD3, CD7, CD8, and Perforin. Fluorescence in situ hybridization analysis revealed a characteristic rearrangement of the ALK-1 gene in 2p23 leading to the diagnosis of ALK-1 positive ALCL. Chemotherapy according to the ALCL-99-NHL-BFM protocol was initiated and resulted in a complete remission after two cycles. This case illustrates the unusual presentation of a pediatric ALCL in soft tissue with a good response to chemotherapy.
KW  - pediatric lymphoma
KW  - psoas muscle
KW  - classification
KW  - translocation
KW  - features
KW  - gene
KW  - ALK-1
KW  - anaplastic large cell lymphoma
KW  - CD30
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-135381
VL  - 7
IS  - 38
ER  -