TY  - CHAP
A1  - Lut, Kateryna
A1  - Starenkova, Hanna
ED  - Lazebna, Nataliia
ED  - Kumar, Dinesh
T1  - The Relationship between Language, Culture, and Development of Society
T2  - Studies in Modern English
N2  - The paper analyses specific characteristics of language that influence the development of culture and societies. The problem of the connection between language and culture has occupied the minds of many famous scientists: some believe that language is a part of the culture as a whole; others think that language is only a form of cultural expression. Undoubtedly, language constitutes a vital component of the cultural background underlying social development. Language is an essential means of communication and interaction. However, language is at the same time sovereign about culture as a whole and can be separate from culture or compared to culture as an equal element (i.e., that language is neither a form nor a component of culture).
KW  - language
KW  - culture
KW  - expression
KW  - development
KW  - communication
KW  - interaction
KW  - component
KW  - social
KW  - connection
KW  - background
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-296484
PB  - Würzburg University Press
CY  - Würzburg
ER  - 
TY  - JOUR
A1  - Feldheim, Jonas
A1  - Wend, David
A1  - Lauer, Mara J.
A1  - Monoranu, Camelia M.
A1  - Glas, Martin
A1  - Kleinschnitz, Christoph
A1  - Ernestus, Ralf-Ingo
A1  - Braunger, Barbara M.
A1  - Meybohm, Patrick
A1  - Hagemann, Carsten
A1  - Burek, Malgorzata
T1  - Protocadherin Gamma C3 (PCDHGC3) is strongly expressed in glioblastoma and its high expression is associated with longer progression-free survival of patients
JF  - International Journal of Molecular Sciences
N2  - Protocadherins (PCDHs) belong to the cadherin superfamily and represent the largest subgroup of calcium-dependent adhesion molecules. In the genome, most PCDHs are arranged in three clusters, α, β, and γ on chromosome 5q31. PCDHs are highly expressed in the central nervous system (CNS). Several PCDHs have tumor suppressor functions, but their individual role in primary brain tumors has not yet been elucidated. Here, we examined the mRNA expression of PCDHGC3, a member of the PCDHγ cluster, in non-cancerous brain tissue and in gliomas of different World Health Organization (WHO) grades and correlated it with the clinical data of the patients. We generated a PCDHGC3 knockout U343 cell line and examined its growth rate and migration in a wound healing assay. We showed that PCDHGC3 mRNA and protein were significantly overexpressed in glioma tissue compared to a non-cancerous brain specimen. This could be confirmed in glioma cell lines. High PCDHGC3 mRNA expression correlated with longer progression-free survival (PFS) in glioma patients. PCDHGC3 knockout in U343 resulted in a slower growth rate but a significantly faster migration rate in the wound healing assay and decreased the expression of several genes involved in WNT signaling. PCDHGC3 expression should therefore be further investigated as a PFS-marker in gliomas. However, more studies are needed to elucidate the molecular mechanisms underlying the PCDHGC3 effects.
KW  - glioblastoma multiforme
KW  - glioma
KW  - astrocytoma
KW  - recurrence
KW  - relapse
KW  - mRNA
KW  - protein
KW  - brain
KW  - expression
KW  - PCDHGC3
KW  - WNT signaling
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284433
SN  - 1422-0067
VL  - 23
IS  - 15
ER  -