TY  - THES
A1  - Büntemeyer, Tjark-Ole
T1  - Wertigkeit der Leberresektion bei Metastasen des Nebennierenkarzinoms - Analyse anhand des Deutschen Nebennierenkarzinom-Registers
T1  - Role of Liverresection in adrenocortical carcinoma liver metastases
N2  - Patienten mit einem hepatisch metastasierten Nebennierenkarzinom und ohne Hinweise auf extrahepatische Tumormanifestationen profitieren von einer Operation im Hinblick auf das Gesamtüberleben. Dies gilt sowohl für synchron- als auch für metachron metastasierte Patienten.
N2  - Liver resection in case of ACC liver metastases can achieve long term survival, but disease free survival is short despite metastasectomy. Time to recurrence is a predictive factor for the outcome.
KW  - Nebenniere
KW  - Leberresektion
KW  - Nebennierenkarzinom
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-155743
ER  - 
TY  - JOUR
A1  - Baur, Johannes
A1  - Büntemeyer, Tjark-Ole
A1  - Megerle, Felix
A1  - Deutschbein, Timo
A1  - Spitzweg, Christine
A1  - Quinkler, Marcus
A1  - Nawroth, Peter
A1  - Kroiss, Matthias
A1  - Germer, Christoph-Thomas
A1  - Fassnacht, Martin
A1  - Steger, Ulrich
T1  - Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study
JF  - BMC Cancer
N2  - Background:
Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can be achieved. To date there are only limited data on the outcome after surgical resection of hepatic metastases of ACC.

Methods:
A retrospective analysis of the German Adrenocortical Carcinoma Registry was conducted. Patients with liver metastases of ACC but without extrahepatic metastases or incomplete tumour resection were included.

Results:
Seventy-seven patients fulfilled these criteria. Forty-three patients underwent resection of liver metastases of ACC. Complete tumour resection (R0) could be achieved in 30 (69.8%). Median overall survival after liver resection was 76.1 months in comparison to 10.1 months in the 34 remaining patients with unresected liver metastases (p < 0.001). However, disease free survival after liver resection was only 9.1 months. Neither resection status (R0/R1) nor extent of liver resection were significant predictive factors for overall survival. Patients with a time interval to the first metastasis/recurrence (TTFR) of greater than 12 months or solitary liver metastases showed significantly prolonged survival.

Conclusions:
Liver resection in the case of ACC liver metastases can achieve long term survival with a median overall survival of more than 5 years, but disease free survival is short despite metastasectomy. Time to recurrence and single versus multiple metastases are predictive factors for the outcome.
KW  - Adrenocortical Carcinoma
KW  - liver resection
KW  - retrospective study
KW  - prognosis
KW  - survival analysis
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-159409
VL  - 17
IS  - 522
ER  -