TY  - JOUR
A1  - Grotemeyer, Alexander
A1  - McFleder, Rhonda Leah
A1  - Wu, Jingjing
A1  - Wischhusen, Jörg
A1  - Ip, Chi Wang
T1  - Neuroinflammation in Parkinson’s disease – putative pathomechanisms and targets for disease-modification
JF  - Frontiers in Immunology
N2  - Parkinson’s disease (PD) is a progressive and debilitating chronic disease that affects more than six million people worldwide, with rising prevalence. The hallmarks of PD are motor deficits, the spreading of pathological α-synuclein clusters in the central nervous system, and neuroinflammatory processes. PD is treated symptomatically, as no causally-acting drug or procedure has been successfully established for clinical use. Various pathways contributing to dopaminergic neuron loss in PD have been investigated and described to interact with the innate and adaptive immune system. We discuss the possible contribution of interconnected pathways related to the immune response, focusing on the pathophysiology and neurodegeneration of PD. In addition, we provide an overview of clinical trials targeting neuroinflammation in PD.
KW  - Parkinson’s disease
KW  - neuroinflammation
KW  - T cells
KW  - microglia
KW  - neurodegeneration
KW  - animal models
KW  - inflammatory cascades
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-274665
SN  - 1664-3224
VL  - 13
ER  -