TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Mephenhydramins T1 - Sila-Analogues of Mephenhydramine N2 - Sila-Analogues A 2, B 2 and C 2 of the drug mephenhydramine from the class of benzhydryl ethers were synthesized for the first time by the steps shown in scheme 1, and they and their precursors I-V characterized by their physical {table 1) and chemical properties, and their structures confirmed by NMR, n1ass and infrared spectroscopy (tables 3-5). Their physiological effects were investigated a.nd compared -with those of the parent carbon compounds (section 5). KW - Anorganische Chemie Y1 - 1975 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63525 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Chlorphenoxamins und des Clofenetamins T1 - Sila-Analogues of Ohlorphenoxamine and Clofenetamine N2 - Sila-ana.logues A 2 and B 2 of two drugs from the benzhydryl ether class, chlorphenoxamine and clofenetamine, were synthesized for the first time by the steps shown in scheme 1. They and their precursors I-VI v;rere characterized by their physical (Table 1) and chemical properties and their structures confirmed by n.m.r., mass and infrared spectroscopy (Tab]es 2-5). Their physiological effects were invest.igated and compared with those of the carbon analogues (Chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63531 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Mebrophenhydramins T1 - Sila-Analogues of Mebrophenhydramine N2 - Sila-analogues A 2, B 2 and C 2 of the drug mebrophenhydramine from the class of benzhydryl ethers -were synthesized for the first time by the steps shown in scheme 1, and they and their precurso:rs I-Ill were characterized by their physical (Table 1) and chemical properties, a.nd their structures confirmed by NMR, mass and infrared spectroscopy (Tables 3-5). The histaminolytic and anticholinergic effects of A 2 and C 2 were investigated and compared with some structure-activity relationships of analogue carbon compounds. KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63542 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analogon des Cicloniumbromids T1 - Sila-Analogue of Ciclonium Bromide N2 - Sila-Analogues B 2 and A 2 of the spasmolytic ciclonium bromide (B 1) respectively the corresponding free base A 1 were synthesized for the first time according to the reaction steps sho·wn in scheme 1, and they and their precursors I and II were characterized by ph;ysical (Table 1} and chemical properties and their structures confirmed by NMR, and mass spectroscopy (Tables 2 and 3}. The pharmacological effects of A 2 and B 2 were investigated and compared with those of the parent carbon compound B 1 (chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63556 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Derivate des Sila-Mephenhydramins und Sila-Chlorphenoxamins T1 - Derivatives of Sila-Mephenhydramine and Sila-Ohlorphenoxamine N2 - Derivatives A and B of the two sila-antihistam.ines silamephenhydramine and sila-chlorphenoxamine were synthesized for the first time by the steps shown in scheme 1. They and their precursors III and IV were characterized by their physical (Table 1) and chemical properties and their structures confirmed by NMR and mass spectroscopy (Tables 2 and 3). Their pharmacological effects were investigated and compared with those of the corresponding sila-antihistamines. KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63562 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Isoelektronische Derivate des Sila-Clofenetamins und des Sila-Mebrophenhydramins T1 - Isoelectronic Derivatives of Sila-Clofenetamine and Sila-Mebrophenhydramine N2 - Isoelectronic derivatives (A and B) and a homolog (C) of the two sila-antihistamines sila-clofenetamine and silamebrophenhydramine were synthesized for the first time by the steps shown in scheme 1. They and their unknown precursors II-IV were characterized by their physical (Table 1) and chemical properties and their structures confinned by lH-NMR and rnass spectroscopy (Tables 2 and 3). The pharrnacological effects of A and B were investigated and compared with those of the corresponding 0-isosteric sila-antihistarnines (Chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63574 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - N-Quaternäre Derivate basischer Sila-benzhydryläther T1 - N-Quaternary Derivatives of Basic Silabenzhydryl Ethers N2 - Die quartären Ammoniumsalze 1-10 einiger bioaktiver Sila-benzhydryläther wurden erstmalig durch Reaktion der entsprechenden freien Basen A-E mit CH\(_3\)J, CH\(_3\)Br bzw. CH\(_3\)Cl in CH\(_3\)CN dargestellt. Die Strukturen von 1-10 wurden durch Elementaranalysen und 1 H-NMR-Spektren bestätigt. Die pharmakologischen Effekte einiger Verbindungen wurden sowohl mit den Eigenschaft der entsprechenden freien Basen als auch mit einigen Struktur-Wirkungsbeziehungen analoger Kohlenstoffverbindungen verglichen. N2 - Quaternary ammonium salts 1-10 of some biologically active silabenzhydryl ethers were synthesized for the frrst time by the reaction of the corresponding free bases A-E with CH\(_3\)I, CH\(_3\)Br or CH\(_3\)Cl in CH\(_3\)CN. The structures of 1-10 were confirmed by elementary analysis and 1 HNMR spectroscopy. The pharmacological effects of some compounds were compared with those of the corresponding free bases and of analogaus carbon cornpounds. KW - Anorganische Chemie Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63583 ER - TY - JOUR A1 - Tacke, Reinhold T1 - Sila-Analoga des Meflophenhydramins T1 - Sila-analogues of Meflophenhydramine N2 - Die Sila-Analoga A, 8, C des Antihistaminikums Meflophenhydramin, sowie die Derivate D und E, das Hydrolyseprodukt 8 und die Vorstufen 3-7 wurden dargestellt. Die chemischen und physikalischen Eigenschaften aller Verbindungen und das pharmakologische Verhalten von A-D und 8 wurden untersucht. N2 - Sila-analogues A, 8, C of the antihistamine meflophenhydramine as weil as the derivatives D and E, the product of hydrolysis 8 and the precursors 3-7 were synthesized. The chemical and physical properties and the pharmacological behaviour of A-D and 8 are described. KW - Anorganische Chemie Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63594 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Saad, S. M. T1 - Silylation of cellulose N2 - Ethane-l:2-diol and propane-l:3-diol reaet with 1: 1:3:3-tetramethyl-l:3-dichlorodisiloxane forming the corresponding rings. However, no ring compounds could be traced tbrough the reaction between butane-l :4-diol, glycerol and the dichlorodisiloxane respectively, where only polymeric compounds are formed. The silylation products of the di- and trihydroxy alcohols, as model compounds, has confirmed that the ring formation during silylation of cellulose with dichlorodisiloxane is uncertain. KW - Anorganische Chemie Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78368 ER - TY - JOUR A1 - Saad, S. M. A1 - Tacke, Reinhold T1 - Zur Darstellung von 1,1,3,3-Tetramethyl-1,3-disila-2,4,7-trioxa-cycloheptan (1) und 1,1,3,3-Tetramethyl-1,3-disila-2,4,8-trioxa-cyclooctan (2) N2 - No abstract available. KW - Anorganische Analyse Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86958 ER -