TY  - JOUR
A1  - Peters, Simon
A1  - Fohmann, Ingo
A1  - Rudel, Thomas
A1  - Schubert-Unkmeir, Alexandra
T1  - A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites
JF  - Cells
N2  - Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration. Over the past decade, sphingolipids have become the focus of intensive studies regarding their involvement in infectious diseases. Pathogens can manipulate the sphingolipid metabolism resulting in cell membrane reorganization and receptor recruitment to facilitate their entry. They may recruit specific host sphingolipid metabolites to establish a favorable niche for intracellular survival and proliferation. In contrast, some sphingolipid metabolites can also act as a first line defense against bacteria based on their antimicrobial activity. In this review, we will focus on the strategies employed by pathogenic Neisseria spp. to modulate the sphingolipid metabolism and hijack the sphingolipid balance in the host to promote cellular colonization, invasion and intracellular survival. Novel techniques and innovative approaches will be highlighted that allow imaging of sphingolipid derivatives in the host cell as well as in the pathogen.
KW  - sphingolipids
KW  - host–pathogen interaction
KW  - Neisseria meningitidis
KW  - Neisseria gonorrhoeae
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-250203
SN  - 2073-4409
VL  - 10
IS  - 11
ER  -