TY  - JOUR
A1  - Dabauvalle, Marie-Christine
A1  - Scheer, Ulrich
T1  - Assembly of nuclear pore complexes in Xenopus egg extract
N2  - No abstract available
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41194
ER  - 
TY  - JOUR
A1  - Sendtner, Michael
A1  - Arakawa, Yoshihiro
A1  - Stöckli, Kurt A.
A1  - Kreutzberg, Georg W.
A1  - Thoenen, Hans
T1  - Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival
N2  - We have demonstrated that the extensive degeneration of motoneurons in the rat facial nucleus after transection of the facial nerve in newborn rats can be prevented by local ciliary neurotrophic factor (CNTF) administration. CNTF differs distinctly from known neurotrophic molecules such as NGF, BDNF and NT-3 in both its molecular characteristics (CNTF is a cytosolic rather than a secretory molecule) and its broad spectrum of biological activities. CNTF is expressed selectively by Schwann cells and astrocytes of the peripheral and central nervous system, respectively, but not by target tissues of the great variety of CNTF -responsive neurons. CNTF mRNA is not detectable by Northern blot or PCR analysis during embryonic development and immediately after birth. However, during the second post-natal week, a more than 30-fold increase in CNTF mRNA and pro tein occurs in the sciatic nerve. Since the period of low CNTF levels in peripheral nerves coincides with that of high vulnerability of motoneurons (i.e. axonallesion results in degeneration of motoneuron cell bodies), insufficient availability of CNTF may be the reason for the rate of lesioninduced cell death of early post-natal motoneurons. Highly enriched embryonic chick motoneurons in culture are supported at survival rates higher than 60% by CNTF, even in single cell cultures, indicating that CNTF acts directly on motoneurons. In contrast to CNTF, the members of the neurotrophin gene family (NGF, BDNF and NT-3) do not support the survival of motoneurons in culture. However, aFGF and bFGF show distinct survival activities which are additive to those of CNTF, resulting in the survival of virtually all motoneurons cultured in the presence of CNTF and bFGF.
KW  - motoneurons
KW  - ciliary neurotrophic factor
KW  - CNTF
KW  - nerve lesion
KW  - rat
KW  - chick
KW  - neurotrophic factor
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33048
ER  - 
TY  - JOUR
A1  - Fischer, Dagmar
A1  - Weißenberger, Dieter
A1  - Scheer, Ulrich
T1  - Assigning functions to nucleolar structures
N2  - Nucleoli provide the fascinating possibility of linking morphologically distinct structures such as those seen in the electron microscope with biochemical f eatures of the formation and step wise maturation of ribosomes. Localization of proteins by immunocytochemistry and of rRNA genes and their transcripts by in situ hybridization has greatly improved our understanding of the structural-functional relationships of the nucleolus. The present review describes some recent results obtained by electron microscopic in situ hybridization and argues that this approach has the potential to correlate each step of the complex pre-rRNA maturation pathway with nucleolar structures. Evidence is accumulating that the nucleolus-specific U3 snRNPs (small nuclear ribonucleoprotein particles) participate in rRNA processing events, similar to the role played by the nucleoplasmic snRNPs in mRNA maturation. The intranucleolar distribution of U3 snRNA is consistent with the view that it is involved in both early and late stages of pre-rRNA processing.
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-34258
ER  - 
TY  - JOUR
A1  - Dandekar, Thomas
T1  - Olbers' Paradox (peer-reviewed scientific correspondence)
N2  - No abstract available
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31672
ER  - 
TY  - JOUR
A1  - Dandekar, Thomas
A1  - Argos, Patrick
T1  - Chaperonin-mediated protein folding at the surface of groEL through a "molten globule" intermediate
N2  - No abstract available
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-29939
ER  - 
TY  - JOUR
A1  - Dandekar, Thomas
T1  - Yeast U3 localization and correct sequence (snR17a) and promotor activity (snR17b) identified by homology search
N2  - No abstract available
KW  - yeast U3 localization
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-29781
ER  -