TY  - THES
A1  - Schriewer, Miriam Leoni
T1  - "Kann der Körper genesen, wo die Seele so gewaltig krankt?" - Weibliche Gemüts- und Nervenleiden in der Patientenkorrespondenz Hahnemanns am Beispiel der Kantorstochter Friederike Lutze (1798-1878)
T1  - "Can the body be cured, when the soul is so seriously ill?" Female mental and nervous diseases in the patient correspondence of Hahnemann considering the example of Friederike Lutze (1798-1878)
N2  - Gegenstand der Untersuchung ist die Patientenkorrespondenz von Samuel Hahnemann mit seiner Patientin Friederike Lutze in der Zeit von 1831 bis 1833. Anhand von Briefen und Tagesberichten werden die Symptome der Patientin, die nach gegenwärtigem Ermessen hauptsächlich psychischer Natur waren, dargelegt und analysiert. Hierbei wird versucht, die zugehörigen Medizinkonzepte und zeitgenössischen Wissensbestände herauszufiltern. Der Zeitraum der Korrespondenz stellt eine Umbruchphase in der Deutung von Gemütssymptomen dar, so dass sowohl humoralpathologische Vorstellungen, wie auch die "Vapeurs" und Nervenleiden als Konzept aufzufinden sind. Selbst die noch in den Kinderschuhen befindliche Psychologie wird von der Patientin aufgegriffen und im Rahmen des Arzt-Patientenverhältnisses thematisiert. Abgeschlossen wird die Arbeit von der Edition aller verfügbaren Krankenberichte und Briefe der Korrespondenz.
N2  - The subject of the study is the patient correspondence between Samuel Hahnemann and Friederike Lutze in the period from 1831 to 1833. On the basis of letters and daily descriptions the perceptions of the patient are shown and analysed. These symptoms were mainly of a mental or psychic nature regarding the current point of view. Hereby among others the medical concepts and contemporary knowledge are focused. The period of time, in which the correspondence took place, represents a time of change concerning the interpretation of mental sensations and perceptions. The tradition of humoral pathology as well as the "vapeurs" and the rise of the "nerves" can be found in the descriptions of the patient. Friederike Lutze even addresses the incipient discipline "psychology", it becomes an important issue in the doctor-patient relationship. The last part of the dissertation represents the transcription of the handwritings.
KW  - Neurasthenie
KW  - Psychisch Kranker
KW  - Gemüt
KW  - Medizingeschichte <Fach>
KW  - Patientin
KW  - Krankheitsverhalten
KW  - Krankenunterlagen
KW  - Patient
KW  - Brief
KW  - Arzt-Patienten-Verhältnis
KW  - Doctor-Patient Relationship
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-56662
ER  - 
TY  - THES
A1  - Widmaier, Benjamin
T1  - 3D-Rekonstruktionen aus DVT-Daten : Eine retrospektive Analyse zur Evaluation der Verlagerungsmaße von Dysgnathiepatienten
T1  - Three-Dimensional Reconstruction of DVT-Data-A Retrospective Analysis to Evaluate Sagittal-Shift Measures of Dysgnathia Patients
N2  - Zusammenfassung In der vorliegenden retrospektiven Studie wurde untersucht, ob die präoperativ festgelegten Verlagerungsmaße mittels 3D-Rekonstruktionen aus DVT-Daten ermittelbar sind. Anschließend wurde anhand eines Patientenkollektivs die Umsetzung der Verlagerungsmaße evaluiert. Zur Auswertung wurden standardisierte Modelle und DVT-Scans von 35 Patienten herangezogen. Die Modelle sowie die DVT-Daten wurden im Zeitraum von November 2007 bis September 2009 erstellt. Alle Patienten wurden in der Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie der Universität Würzburg aufgrund einer Dysgnathie behandelt. Für die Auswahl der Patienten spielte weder das Alter, das Geschlecht noch der Schweregrad der Dysgnathie eine Rolle. Die Auswertung erfolgte postoperativ durch zwei unabhängige Prüfer, wobei die Patienten zufällig verteilt wurden. Bevor die Umsetzung der Verlagerungsmaße evaluiert wurde, sind die Methodik und die Genauigkeit der Messungen überprüft worden. Die Vermessung der Modelle wurde manuell durchgeführt. Die Analyse der DVT-Daten erfolgte mit einer 3D-Software. Die Ergebnisse der Methodik sind statistisch deskriptiv ausgewertet und interpretiert worden. Für die Evaluation wurde eine kumulative Verteilung erstellt und bewertet. In dieser Studie konnte gezeigt werden, dass man anhand von prä- und postoperativ erstellten DVT-Daten die bei der präoperativen Modell-OP festgelegten Verlagerungsmaße mit den postoperativ erzeugten 3D-Rekonstruktionen vergleichend messen kann. Allerdings ist bei Diskrepanzen der Werte von weniger als 0,97mm von Messungenauigkeiten auszugehen. Desweiteren kann anhand dieser Nachuntersuchung festgehalten werden, dass die Ergebnisse bei 7 der 9 Parameter in 77%-95% der Fälle keine Diskrepanzen aufweisen, die über dem klinisch geforderten Maß liegen. Die einzigen Parameter, die aufgrund der Datenlage eine andere Interpretation nach sich ziehen, sind die Angaben, die hinsichtlich der sagittalen Verlagerung im Unterkiefer gemacht werden. Hierbei kommt es in etwa 40% der Fälle zu Differenzen zwischen den prä- und postoperativen Verlagerungsmaßen, die deutlich größer als 2mm sind. Dabei kann in ca. 60% der Fälle eine zu kleine und in ca. 40% eine zu große Verlagerung festgestellt werden. Eine Aussage über die Feststellung hinaus, dass diese Differenzen bestehen, ist mittels dieser Studie nicht zulässig. Dies liegt zum einen an dem kleinen Patientenkollektiv, das zusätzlich in sich inhomogen war und bei dem unterschiedliche Operationsverfahren zum Einsatz kamen. Die Gründe für diese Unterschiede bzw. deren klinische Relevanz sollte das Ziel einer künftigen Arbeit sein. Allerdings kann durch diese Arbeit gezeigt werden, dass die digitale Volumentomographie dazu verwendet werden kann, bei Dysgnathiepatienten das Operationsziel zu überprüfen und bei Komplikationen zu eruieren, ob der Fehler auf die skelettale Verlagerung zurückzuführen ist oder ob eine andere Ursache ausgemacht werden muss.
N2  - Summary The thesis investigates whether preoperatively stipulated dystopia measures can be identified from DVT data by applying three-dimensional reconstructions. Based on data from a patient sample, the implementation of dystopia measures was empirically evaluated. Standardised models and DVT scans of 35 patients were used for the evaluation. Both building the models and compiling the DVT-data took place between November 2007 and September 2009. All subjects were dysgnathy patients at the University of Würzburg’s hospital for oral and maxillofacial surgery. Patients’ age, sex and severity of dysgnathy did not matter for sample selection. Two independent examiners evaluated the results postoperatively. Patients were allocated randomly. Before the implementation of the dystopia measures took place, both methodology and accuracy of measurement had been reviewed. The models were measured manually and the DVT data was analysed with a 3D software package. The results of this method were statistically descriptive evaluated and interpreted. For the evaluation a cumulative distribution was developed and analysed. This study shows that, by using DVT data – compiled pre- and postoperatively – dystopia measures, which were stipulated in the preoperative model surgery, can be compared to the postoperatively created three-dimensional reconstructions. However there are discrepancies in the data of less then 0,97mm due to measuring inaccuracy. Moreover, the follow-up examination revealed that the results of seven out of the nine parameters do not show statistically significant discrepancies, which are below clinical standards, in 77-95 percent of the observations. The only parameters for which the data allow a different interpretation are the indications with respect to the sagittal shift in the lower jaw. In about 40 percent of the cases we observe significant differences (clearly exceeding 2mm) between preoperative and postoperative shift measures. We observe too small and too large a shift in about 60 and 40 percent of the cases, respectively. The study does not allow conclusions beyond the statement that these differences exist. This is due to the small sample size and subject heterogeneity. Additionally, different surgical methods have been applied. Further research should focus on identifying the causes and clinical relevance of these discrepancies. We show, however, that volume tomography can be used with dysgnathy patients to evaluate whether the surgery’s objective was accomplished or not. Furthermore, in case of complications, volume tomography can show whether these problems are caused by a skeletal shift or must be explained differently.
KW  - Kraniometrie
KW  - Dysgnathie
KW  - Volumentomographie
KW  - Kraniometrie
KW  - Dysgnathie
KW  - Volumentomographie
KW  - Modell-OP
KW  - Kephalometrie
KW  - Cephalometry
KW  - CBCT
KW  - malocclusion
KW  - dysgnathia
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-53901
ER  - 
TY  - THES
A1  - Göbel, Tim
T1  - 4-Piperidonderivate als potenzielle DOHH-Inhibitoren: ein neuer Ansatz zur Therapie tropischer Infektionskrankheiten
T1  - 4-Piperidone derivatives as potential DOHH-inhibotors: a new approach for the therapy of tropical diseases
N2  - Die vorliegende Arbeit beschäftigte sich mit der Entwicklung und Synthese von Inhibitoren der Deoxyhypusin-Hydroxylase (DOHH), die einen wichtigen Schritt in der Aktivierung des eukaryotischen Translationsinitiations-Faktors-5A (eIF-5A) katalysiert. Die Hemmung dieses Metalloenzyms durch kleine Moleküle, die mit dem katalytischen Eisenatom im aktiven Zentrum der DOHH einen Chelatkomplex bilden, hat einen antiproliferativen Effekt auf parasitäre Erreger, wie Plasmodien, Trypanosomen und Leishmanien zur Folge. Ausgehend von den antiplasmodial wirksamen Eisenkomplexbildnern und Pyridon-Derivaten Ciclopirox und Mimosin wurden besser wirksame 2,6-Diaryl-4-oxopiperidincarbonsäuremono- und -diester-Derivate abgeleitet, deren 4-Piperidon-Grundgerüst als Leitstruktur für die Entwicklung von antiplasmodialen und antitrypanosomalen Wirkstoffen fungierte. Entsprechend dieser Leitstrukturen gelang im Zuge dieser Arbeit durch verschiedene Modifikationen der Doppel-Mannich-Reaktion die Erstellung einer weitreichenden Bibliothek 52 strukturell diverser 4-Hydroxytetrahydropyridin-3,5-dicarbonsäurediester 1 – 6, darunter auch erstmals Derivate mit t-Butyl-esterfunktionen und 4-Hydroxytetrahydropyridin-3-carbonsäuremonoester 7 – 8. Dabei konnten vor allem Derivate mit der gewünschten nitroaromatischen Substitution in den Positionen 2 und 6 synthetisiert werden. Darüber hinaus wurden vielfältige Strukturabwandlungen dieser Substanzen in Form von verschiedenen 4-Piperidonderivaten ohne Esterfunktionen, deren Oximen sowie von 4-Hydroxychinoloncarbonsäureestern syn-thetisiert. Die hergestellten Derivate wurden In-vitro-Testungen an Plasmodium falciparum, Trypanosoma brucei brucei und Leishmania major unterzogen. Zusätzlich wurde die Zytotoxizität an der Makrophagen-Zelllinie J774.1 ermittelt.
N2  - The present work focused on the development and synthesis of inhibitors of deoxyhypusine hydroxylase (DOHH) that catalyzes an important step in the activation cascade of eukaryotic initiation factor 5A (eIF-5A). The inhibition of this metal-containing enzyme by small molecules chelating the essential catalytic iron at the active site of DOHH leads to an antiproliferative effect on parasites such as plasmodia, trypanosoma and leishmania. Derived from the antiplasmodial iron chelators and pyridine derivatives ciclopirox and mimosine more potent 2,6-diaryl-4-oxopiperidiniumcarboxylic acid mono- and -diester derivatives were developed. Its 4-piperidone skeleton served as a lead structure for the development of antiplasmodial and antitrypanosomal agents. Based on these lead structures it was possible to build a broad variety of 52 4-hydroxytetrahydropyridine-3,5-dicarboxylates 1 – 6 (for the first time including derivatives with t-butyl-ester functions) as well as 4-hydroxytetrahydropyridine-3-monocarboxylates 7 – 8 with varying substitution patterns by various modifications of the double mannich reaction. Thereby it was possible to synthesize derivatives with the advantageous nitro-aromatic substitution in position 2 and 6. Additionally structural modifications of these compounds such as 4-piperidones without ester functions, corresponding oximes and 4-hydroxychinolone carboxylates have been synthesized, too. The synthesized substances were tested against Plasmodium falciparum, Trypanosoma brucei brucei and Leishmania major. Furthermore their cytotoxity was determined using the macrophage cell line J774.1.
KW  - Malaria
KW  - Trypanosomen
KW  - Piperidinderivate
KW  - Polyaminstoffwechsel
KW  - Mannich-Reaktion
KW  - malaria
KW  - trypanosomiasis
KW  - piperidine derivatives
KW  - polyamine pathway
KW  - mannich reaction
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-57514
ER  - 
TY  - JOUR
A1  - Chen, Y.
A1  - Palm, F.
A1  - Lesch, K. P.
A1  - Gerlach, M.
A1  - Moessner, R.
A1  - Sommer, C.
T1  - 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice
N2  - Background: The role of serotonin (5-hydroxytrptamine, 5-HT) in the modulation of pain has been widely studied. Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain thresholds. Results: In the present study, we investigated the role of 5-HIAA in inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant (CFA) into the hind paw of mice. Wild-type mice were compared to mice deficient of the 5-HT transporter (5-HTT-/- mice) using behavioral tests for hyperalgesia and high-performance liquid chromatography (HPLC) to determine tissue levels of 5-HIAA. Wild-type mice reproducibly developed thermal hyperalgesia and paw edema for 5 days after CFA injection. 5-HTT-/- mice treated with CFA had reduced thermal hyperalgesia on day 1 after CFA injection and normal responses to heat hereafter. The 5-HIAA levels in spinal cord and sciatic nerve as measured with HPLC were lower in 5-HTT-/- mice than in wild-type mice after CFA injection. Pretreatment of wild-type mice with intraperitoneal injection of para-chlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, resulted in depletion of the 5-HIAA content in spinal cord and sciatic nerve and decrease in thermal hyperalgesia in CFA injected mice. The application of exogenous 5-HIAA resulted in potentiation of thermal hyperalgesia induced by CFA in 5-HTT-/- mice and in wild-type mice pretreated with p- CPA, but not in wild-type mice without p-CPA pretreatment. Further, methysergide, a broad-spectrum serotonin receptor antagonist, had no effect on 5-HIAA-induced potentiation of thermal hyperalgesia in CFA-treated wildtype mice. Conclusion: Taken together, the present results suggest that 5-HIAA plays an important role in modulating peripheral thermal hyperalgesia in CFA induced inflammation, probably via a non-serotonin receptor mechanism.
KW  - Medizin
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-68858
ER  - 
TY  - JOUR
A1  - Eulalio, Ana
A1  - Fröhlich, Kathrin S.
A1  - Mano, Miguel
A1  - Giacca, Mauro
A1  - Vogel, Jörg
T1  - A Candidate Approach Implicates the Secreted Salmonella Effector Protein SpvB in P-Body Disassembly
N2  - P-bodies are dynamic aggregates of RNA and proteins involved in several post-transcriptional regulation processes. Pbodies have been shown to play important roles in regulating viral infection, whereas their interplay with bacterial pathogens, specifically intracellular bacteria that extensively manipulate host cell pathways, remains unknown. Here, we report that Salmonella infection induces P-body disassembly in a cell type-specific manner, and independently of previously characterized pathways such as inhibition of host cell RNA synthesis or microRNA-mediated gene silencing. We show that the Salmonella-induced P-body disassembly depends on the activation of the SPI-2 encoded type 3 secretion system, and that the secreted effector protein SpvB plays a major role in this process. P-body disruption is also induced by the related pathogen, Shigella flexneri, arguing that this might be a new mechanism by which intracellular bacterial pathogens subvert host cell function.
KW  - Salmonella
KW  - RNS
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-68928
ER  - 
TY  - JOUR
A1  - Niewalda, Thomas
A1  - Völler, Thomas
A1  - Eschbach, Claire
A1  - Ehmer, Julia
A1  - Wen-Chuang, Chou
A1  - Timme, Marc
A1  - Fiala, André
A1  - Gerber, Bertram
T1  - A Combined Perceptual, Physico-Chemical, and Imaging Approach to 'Odour-Distances' Suggests a Categorizing Function of the Drosophila Antennal Lobe
JF  - PLoS One
N2  - How do physico-chemical stimulus features, perception, and physiology relate? Given the multi-layered and parallel architecture of brains, the question specifically is where physiological activity patterns correspond to stimulus features and/or perception. Perceived distances between six odour pairs are defined behaviourally from four independent odour recognition tasks. We find that, in register with the physico-chemical distances of these odours, perceived distances for 3octanol and n-amylacetate are consistently smallest in all four tasks, while the other five odour pairs are about equally distinct. Optical imaging in the antennal lobe, using a calcium sensor transgenically expressed in only first-order sensory or only second-order olfactory projection neurons, reveals that 3-octanol and n-amylacetate are distinctly represented in sensory neurons, but appear merged in projection neurons. These results may suggest that within-antennal lobe processing funnels sensory signals into behaviourally meaningful categories, in register with the physico-chemical relatedness of the odours.
KW  - organization
KW  - cameleon
KW  - honeybee
KW  - map
KW  - neurons
KW  - reveals
KW  - melanogaster
KW  - mushroom body
KW  - spatial representation
KW  - olfactory information
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-133510
VL  - 6
IS  - 9
ER  - 
TY  - JOUR
A1  - Niewalda, Thomas
A1  - Völler, Thomas
A1  - Eschbach, Claire
A1  - Ehmer, Julia
A1  - Chou, Wen-Chuang
A1  - Timme, Marc
A1  - Fiala, André
A1  - Gerber, Bertram
T1  - A Combined Perceptual, Physico-Chemical, and ImagingApproach to ‘Odour-Distances’ Suggests a CategorizingFunction of the Drosophila Antennal Lobe
N2  - How do physico-chemical stimulus features, perception, and physiology relate? Given the multi-layered and parallel architecture of brains, the question specifically is where physiological activity patterns correspond to stimulus features and/ or perception. Perceived distances between six odour pairs are defined behaviourally from four independent odour recognition tasks. We find that, in register with the physico-chemical distances of these odours, perceived distances for 3-octanol and n-amylacetate are consistently smallest in all four tasks, while the other five odour pairs are about equally distinct. Optical imaging in the antennal lobe, using a calcium sensor transgenically expressed in only first-order sensory or only second-order olfactory projection neurons, reveals that 3-octanol and n-amylacetate are distinctly represented in sensory neurons, but appear merged in projection neurons. These results may suggest that within-antennal lobe processing funnels sensory signals into behaviourally meaningful categories, in register with the physico-chemical relatedness of the odours.
KW  - Drosophila Antennal Lobe
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-74769
ER  - 
TY  - THES
A1  - Rüth, Michael
T1  - A Comprehensive Study of Dilute Magnetic Semiconductor Resonant Tunneling Diodes
T1  - Umfassende Untersuchung von resonanten Tunneldioden aus verdünnt-magnetischen Halbleitern
N2  - We investigate transport measurements on all II-VI semiconductor resonant tunneling diodes (RTDs). Being very versatile, the dilute magnetic semiconductor (DMS) system (Zn,Be,Mn,Cd)Se is a perfect testbed for various spintronic device designs, as it allows for separate control of electrical and magnetic properties. In contrast to the ferromagnetic semiconductor (Ga,Mn)As, doping ZnSe with Mn impurities does not alter the electrical properties of the semiconductor, as the magnetic dopant is isoelectric in the ZnSe host.
N2  - Diese Doktorarbeit befasst sich mit Transportmessungen an resonanten Tunneldioden (engl. resonant tunneling diode, RTD), welche vollst� andig aus II-VI Halbleitermaterial bestehen. Das verd� unnt magnetische (engl. dilute magnetic semiconductor, DMS) Halbleitermaterialsystem (Zn,Be,Mn,Cd)Se ist sehr vielseitig und eignet sich hervorragend als Testsystem f� ur diverse Spintronik Bauelemente, denn magnetische und elektrische Eigenschaften lassen sich getrennt voneinander einstellen. Im Gegensatz zum ferromagnetischen Halbleiter (Ga,Mn)As ver� andert das Dotieren von ZnSe mit Mn nicht die elektrischen Eigenschaften des Halbleiters.
KW  - Semimagnetischer Halbleiter
KW  - Resonanz-Tunneleffekt
KW  - Halbleiter
KW  - Resonante Tunneldioden
KW  - Spintronik
KW  - dilute magnetic semiconductors
KW  - spintronics
KW  - resonant tunneling diodes
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-71472
ER  - 
TY  - JOUR
A1  - Kistler, Andreas D.
A1  - Siwy, Justyna
A1  - Frank, Breunig
A1  - Jeevaratnam, Praveen
A1  - Scherl, Alexander
A1  - Mullen, William
A1  - Warnock, David G.
A1  - Wanner, Christoph
A1  - Hughes, Derralynn A.
A1  - Mischak, Harald
A1  - Wüthrich, Rudolf P.
A1  - Serra, Andreas L.
T1  - A Distinct Urinary Biomarker Pattern Characteristic of Female Fabry Patients That Mirrors Response to Enzyme Replacement Therapy
JF  - PLoS ONE
N2  - Female patients affected by Fabry disease, an X-linked lysosomal storage disorder, exhibit a wide spectrum of symptoms, which renders diagnosis, and treatment decisions challenging. No diagnostic test, other than sequencing of the alpha-galactosidase A gene, is available and no biomarker has been proven useful to screen for the disease, predict disease course and monitor response to enzyme replacement therapy. Here, we used urine proteomic analysis based on capillary electrophoresis coupled to mass spectrometry and identified a biomarker profile in adult female Fabry patients. Urine samples were taken from 35 treatment-naive female Fabry patients and were compared to 89 age-matched healthy controls. We found a diagnostic biomarker pattern that exhibited 88.2% sensitivity and 97.8% specificity when tested in an independent validation cohort consisting of 17 treatment-naive Fabry patients and 45 controls. The model remained highly specific when applied to additional control patients with a variety of other renal, metabolic and cardiovascular diseases. Several of the 64 identified diagnostic biomarkers showed correlations with measures of disease severity. Notably, most biomarkers responded to enzyme replacement therapy, and 8 of 11 treated patients scored negative for Fabry disease in the diagnostic model. In conclusion, we defined a urinary biomarker model that seems to be of diagnostic use for Fabry disease in female patients and may be used to monitor response to enzyme replacement therapy.
KW  - Chronic kidney-disease
KW  - Onset hypertrophic cardiomyopathy
KW  - Mass-spectrometry
KW  - Alpha-galactosidase
KW  - Hemodialysis-patients
KW  - Clinical proteomics
KW  - Young-patients
KW  - Discovery
KW  - Globotriaosylceramide
KW  - Prevalence
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-133526
VL  - 6
IS  - 6
ER  - 
TY  - BOOK
A1  - Falk, Michael
A1  - Marohn, Frank
A1  - Michel, René
A1  - Hofmann, Daniel
A1  - Macke, Maria
A1  - Tewes, Bernward
A1  - Dinges, Peter
A1  - Spachmann, Christoph
A1  - Englert, Stefan
T1  - A First Course on Time Series Analysis : Examples with SAS
N2  - The analysis of real data by means of statistical methods with the aid of a software package common in industry and administration usually is not an integral part of mathematics studies, but it will certainly be part of a future professional work. The present book links up elements from time series analysis with a selection of statistical procedures used in general practice including the statistical software package SAS. Consequently this book addresses students of statistics as well as students of other branches such as economics, demography and engineering, where lectures on statistics belong to their academic training. But it is also intended for the practician who, beyond the use of statistical tools, is interested in their mathematical background. Numerous problems illustrate the applicability of the presented statistical procedures, where SAS gives the solutions. The programs used are explicitly listed and explained. No previous experience is expected neither in SAS nor in a special computer system so that a short training period is guaranteed. This book is meant for a two semester course (lecture, seminar or practical training) where the first three chapters can be dealt within the first semester. They provide the principal components of the analysis of a time series in the time domain. Chapters 4, 5 and 6 deal with its analysis in the frequency domain and can be worked through in the second term. In order to understand the mathematical background some terms are useful such as convergence in distribution, stochastic convergence, maximum likelihood estimator as well as a basic knowledge of the test theory, so that work on the book can start after an introductory lecture on stochastics. Each chapter includes exercises. An exhaustive treatment is recommended. Chapter 7 (case study) deals with a practical case and demonstrates the presented methods. It is possible to use this chapter independent in a seminar or practical training course, if the concepts of time series analysis are already well understood. This book is consecutively subdivided in a statistical part and an SAS-specific part. For better clearness the SAS-specific parts are highlighted. This book is an open source project under the GNU Free Documentation License.
KW  - Zeitreihenanalyse
KW  - Box-Jenkins-Verfahren
KW  - SAS <Programm>
KW  - Zustandsraummodelle
KW  - Time Series Analysis
KW  - State-Space Models
KW  - Frequency Domain
KW  - Box–Jenkins Program
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-56489
N1  - Version: 2011-March-01
ER  -