TY  - JOUR
A1  - Al-Janabi, Omar
A1  - Taubert, Helge
A1  - Lohse-Fischer, Andrea
A1  - Fröhner, Michael
A1  - Wach, Sven
A1  - Stöhr, Robert
A1  - Keck, Bastian
A1  - Burger, Max
A1  - Wieland, Wolf
A1  - Erdmann, Kati
A1  - Wirth, Manfred P.
A1  - Wullich, Bernd
A1  - Baretton, Gustavo
A1  - Magdolen, Viktor
A1  - Kotzsch, Mathias
A1  - Füssel, Susanne
T1  - Association of Tissue mRNA and Serum Antigen Levels of Members of the Urokinase-Type Plasminogen Activator System with Clinical and Prognostic Parameters in Prostate Cancer
JF  - Biomed Research International
N2  - The objective was to determine the mRNA expression and protein levels of uPA system components in tissue specimens and serum samples, respectively, from prostate cancer (PCa) patients and to assess their association with clinicopathological parameters and overall survival (OS). The mRNA expression levels of uPA, its receptor (uPAR), and its inhibitor type 1 (PAI-1) were analyzed in corresponding malignant and adjacent nonmalignant tissue specimens from 132 PCa patients by quantitative PCR. Preoperative serum samples from 81 PCa patients were analyzed for antigen levels of uPA system members by ELISA. RNA levels of uPA system components displayed significant correlations with each other in the tumor tissues. A significantly decreased uP AmRNA expression in PCa compared to the corresponding nonmalignant tissue was detected. High uPA mRNA level was significantly associated with a high Gleason score. Elevated concentration of soluble uPAR (suPAR) in serum was significantly associated with a poor OS of PCa patients (P = 0.022). PCa patients with high suPAR levels have a significantly higher risk of death (multivariate Cox's regression analysis; IIR - 7.12, P - 0.027). The association of high suPAR levels with poor survival of PCa patients suggests a prognostic impact of suPAR levels in serum of cancer patients.
KW  - receptor splice variant
KW  - primary breast cancer
KW  - radical prostatectomy
KW  - tumor tissue
KW  - progression
KW  - potential marker
KW  - inhibitor PAI-1
KW  - gastric cancer
KW  - biomarkers UPA
KW  - expression
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117967
SN  - 2314-6141
IS  - 972587
ER  -