TY  - JOUR
A1  - Gessner, Viktoria H.
T1  - Diphenyl[2-(phenyl-sulfon-yl)propan-2-yl]-\(\lambda^5\)-phosphanethione
JF  - Acta crystallographica. Section E, Structure reports online
N2  - The title compound, \(C_{21}H_{21}O_2PS_2\), was obtained from the corresponding dilithio methandiide by treatment with iodo-methane. The bond lengths and angles deviate considerably from those in the dimetallated compound. These differences are most pronounced in the PCS backbone. While the title compound features C-P and C-S distances of 1.9082(17) and 1.8348(17)Å, respectively, the dianion showed \(C-P_{av}\) distances shortened by 11% [1.710(4)Å] and C-S distances shortened by 12% [1.614(3)Å]. Additionally, the P-C-S angle experiences a contraction by methyl-ation of the dianion from 121.4(2) to 111.96(9)° in the title compound.
KW  - wR factor = 0.068
KW  - mean σ(C–C) = 0.003 Å
KW  - T = 173 K
KW  - single-crystal X-ray study
KW  - R factor = 0.025
KW  - data-to-parameter ratio = 14.6
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-123635
VL  - E68
IS  - o1045
ER  - 
TY  - JOUR
A1  - Hartung, Andreas
A1  - Seufert, Florian
A1  - Berges, Carsten
A1  - Gessner, Viktoria H.
A1  - Holzgrabe, Ulrike
T1  - One-Pot Ugi/Aza-Michael Synthesis of Highly Substituted 2,5-Diketopiperazines with Anti-Proliferative Properties
JF  - Molecules
N2  - The well-known Ugi reaction of aldehydes with amines, carboxylic acids and isocyanides leads to the formation of acyclic alpha-acylaminocarboxamides. Replacement of the carboxylic acid derivatives with beta-acyl substituted acrylic acids gives access to highly substituted 2,5-diketopiperazines in one single reaction-step without additives or complex reaction procedures. The obtained diketopiperazines show anti-proliferative effects on activated T cells and represent therefore potential candidates for targeting unwanted T cell-mediated immune responses.
KW  - multicomponent Ugi-type reaction
KW  - intramolecular Michael addition
KW  - strategy
KW  - derivates
KW  - diketopiperazines
KW  - chemistry
KW  - T cell
KW  - 2,5-diketopiperazines
KW  - anti-proliferative effects
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-130423
VL  - 17
IS  - 12
ER  -