TY  - JOUR
A1  - Zahran, Eman Maher
A1  - Albohy, Amgad
A1  - Khalil, Amira
A1  - Ibrahim, Alyaa Hatem
A1  - Ahmed, Heba Ali
A1  - El-Hossary, Ebaa M.
A1  - Bringmann, Gerhard
A1  - Abdelmohsen, Usama Ramadan
T1  - Bioactivity Potential of Marine Natural Products from Scleractinia-Associated Microbes and In Silico Anti-SARS-COV-2 Evaluation
JF  - Marine Drugs
N2  - Marine organisms and their associated microbes are rich in diverse chemical leads. With the development of marine biotechnology, a considerable number of research activities are focused on marine bacteria and fungi-derived bioactive compounds. Marine bacteria and fungi are ranked on the top of the hierarchy of all organisms, as they are responsible for producing a wide range of bioactive secondary metabolites with possible pharmaceutical applications. Thus, they have the potential to provide future drugs against challenging diseases, such as cancer, a range of viral diseases, malaria, and inflammation. This review aims at describing the literature on secondary metabolites that have been obtained from Scleractinian-associated organisms including bacteria, fungi, and zooxanthellae, with full coverage of the period from 1982 to 2020, as well as illustrating their biological activities and structure activity relationship (SAR). Moreover, all these compounds were filtered based on ADME analysis to determine their physicochemical properties, and 15 compounds were selected. The selected compounds were virtually investigated for potential inhibition for SARS-CoV-2 targets using molecular docking studies. Promising potential results against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and methyltransferase (nsp16) are presented.
KW  - Scleractinia
KW  - marine bacteria
KW  - marine fungi
KW  - zooxanthellae
KW  - marine natural products
KW  - ADME analysis
KW  - SARS-CoV-2
KW  - molecular docking
KW  - RNA-dependent RNA polymerase
KW  - methyltransferase
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220041
SN  - 1660-3397
VL  - 18
IS  - 12
ER  - 
TY  - JOUR
A1  - El-Hossary, Ebaa M.
A1  - Abdel-Halim, Mohammad
A1  - Ibrahim, Eslam S.
A1  - Pimentel-Elardo, Sheila Marie
A1  - Nodwell, Justin R.
A1  - Handoussa, Heba
A1  - Abdelwahab, Miada F.
A1  - Holzgrabe, Ulrike
A1  - Abdelmohsen, Usama Ramadan
T1  - Natural Products Repertoire of the Red Sea
JF  - Marine Drugs
N2  - Marine natural products have achieved great success as an important source of new lead compounds for drug discovery. The Red Sea provides enormous diversity on the biological scale in all domains of life including micro- and macro-organisms. In this review, which covers the literature to the end of 2019, we summarize the diversity of bioactive secondary metabolites derived from Red Sea micro- and macro-organisms, and discuss their biological potential whenever applicable. Moreover, the diversity of the Red Sea organisms is highlighted as well as their genomic potential. This review is a comprehensive study that compares the natural products recovered from the Red Sea in terms of ecological role and pharmacological activities.
KW  - Red Sea
KW  - marine natural products
KW  - marine organisms
KW  - biodiversity
KW  - marine metagenomics
KW  - bioactivity
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-213110
SN  - 1660-3397
VL  - 18
IS  - 9
ER  - 
TY  - JOUR
A1  - Shady, Nourhan Hisham
A1  - El-Hossary, Ebaa M.
A1  - Fouad, Mostafa A.
A1  - Gulder, Tobias A. M.
A1  - Kamel, Mohamed Salah
A1  - Abdelmohsen, Usama Ramadan
T1  - Bioactive natural products of marine sponges from the Genus Hyrtios
JF  - Molecules
N2  - Marine sponges are known as a rich source for novel bioactive compounds with valuable pharmacological potential. One of the most predominant sponge genera is Hyrtios, reported to have various species such as Hyrtios erectus, Hyrtios reticulatus, Hyrtios gumminae, Hyrtios communis, and Hyrtios tubulatus and a number of undescribed species. Members of the genus Hyrtios are a rich source of natural products with diverse and valuable biological activities, represented by different chemical classes including alkaloids, sesterterpenes and sesquiterpenes. This review covers the literature until June 2016, providing a complete survey of all compounds isolated from the genus Hyrtios with their corresponding biological activities whenever applicable.
KW  - alkaloids
KW  - bioactive
KW  - marine natural products
KW  - marine sponges
KW  - Hyrtios
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-158227
VL  - 22
IS  - 5
ER  -