TY  - JOUR
A1  - Liang, Chunguang
A1  - Bencurova, Elena
A1  - Psota, Eric
A1  - Neurgaonkar, Priya
A1  - Prelog, Martina
A1  - Scheller, Carsten
A1  - Dandekar, Thomas
T1  - Population-predicted MHC class II epitope presentation of SARS-CoV-2 structural proteins correlates to the case fatality rates of COVID-19 in different countries
JF  - International Journal of Molecular Sciences
N2  - We observed substantial differences in predicted Major Histocompatibility Complex II (MHCII) epitope presentation of SARS-CoV-2 proteins for different populations but only minor differences in predicted MHCI epitope presentation. A comparison of this predicted epitope MHC-coverage revealed for the early phase of infection spread (till day 15 after reaching 128 observed infection cases) highly significant negative correlations with the case fatality rate. Specifically, this was observed in different populations for MHC class II presentation of the viral spike protein (p-value: 0.0733 for linear regression), the envelope protein (p-value: 0.023), and the membrane protein (p-value: 0.00053), indicating that the high case fatality rates of COVID-19 observed in some countries seem to be related with poor MHC class II presentation and hence weak adaptive immune response against these viral envelope proteins. Our results highlight the general importance of the SARS-CoV-2 structural proteins in immunological control in early infection spread looking at a global census in various countries and taking case fatality rate into account. Other factors such as health system and control measures become more important after the early spread. Our study should encourage further studies on MHCII alleles as potential risk factors in COVID-19 including assessment of local populations and specific allele distributions.
KW  - COVID-19
KW  - population coverage
KW  - MHC II
KW  - MHC I
KW  - B-cell
KW  - T-cell
KW  - epitope mapping
KW  - lethality rate
KW  - infection spread
KW  - SARS-CoV-2
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-258936
SN  - 1422-0067
VL  - 22
IS  - 5
ER  - 
TY  - JOUR
A1  - Frantz, Stefan
A1  - Falcao-Pires, Ines
A1  - Balligand, Jean-Luc
A1  - Bauersachs, Johann
A1  - Brutsaert, Dirk
A1  - Ciccarelli, Michele
A1  - Dawson, Dana
A1  - de Windt, Leon J.
A1  - Giacca, Mauro
A1  - Hamdani, Nazha
A1  - Hilfiker-Kleiner, Denise
A1  - Hirsch, Emilio
A1  - Leite-Moreira, Adelino
A1  - Mayr, Manuel
A1  - Thum, Thomas
A1  - Tocchetti, Carlo G.
A1  - van der Velden, Jolanda
A1  - Varricchi, Gilda
A1  - Heymans, Stephane
T1  - The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC
JF  - European Journal of Heart Failure
N2  - Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a maladaptive role of the immune system. However, several phase III trials failed to show beneficial effects in HF with therapies directed against an immune activation. Preclinical studies today describe positive and negative effects of immune activation in HF. These different effects depend on timing and aetiology of HF. Therefore, herein we give a detailed review on immune mechanisms and their importance for the development of HF with a special focus on commonalities and differences between different forms of cardiomyopathies. The role of the immune system in ischaemic, hypertensive, diabetic, toxic, viral, genetic, peripartum, and autoimmune cardiomyopathy is discussed in depth. Overall, initial damage to the heart leads to disease specific activation of the immune system whereas in the chronic phase of HF overlapping mechanisms occur in different aetiologies.
KW  - immune system
KW  - macrophage
KW  - T-cell
KW  - ischaemic cardiomyopathy
KW  - hypertensive cardiomyopathy
KW  - diabetic cardiomyopathy
KW  - toxic cardiomyopathy
KW  - viral cardiomyopathy
KW  - genetic cardiomyopathy
KW  - peripartum cardiomyopathy
KW  - autoimmune cardiomyopathy
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-229091
VL  - 20
ER  - 
TY  - JOUR
A1  - Moll, Heidrun
A1  - Fuchs, Harald
A1  - Blank, Christine
A1  - Röllinghoff, Martin
T1  - Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells
N2  - No abstract available
KW  - Immunologie
KW  - Langerhans cell
KW  - Leishmania major
KW  - T-cell
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46023
ER  -