TY  - JOUR
A1  - Shady, Nourhan Hisham
A1  - El-Hossary, Ebaa M.
A1  - Fouad, Mostafa A.
A1  - Gulder, Tobias A. M.
A1  - Kamel, Mohamed Salah
A1  - Abdelmohsen, Usama Ramadan
T1  - Bioactive natural products of marine sponges from the Genus Hyrtios
JF  - Molecules
N2  - Marine sponges are known as a rich source for novel bioactive compounds with valuable pharmacological potential. One of the most predominant sponge genera is Hyrtios, reported to have various species such as Hyrtios erectus, Hyrtios reticulatus, Hyrtios gumminae, Hyrtios communis, and Hyrtios tubulatus and a number of undescribed species. Members of the genus Hyrtios are a rich source of natural products with diverse and valuable biological activities, represented by different chemical classes including alkaloids, sesterterpenes and sesquiterpenes. This review covers the literature until June 2016, providing a complete survey of all compounds isolated from the genus Hyrtios with their corresponding biological activities whenever applicable.
KW  - alkaloids
KW  - bioactive
KW  - marine natural products
KW  - marine sponges
KW  - Hyrtios
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-158227
VL  - 22
IS  - 5
ER  - 
TY  - JOUR
A1  - Abdelmohsen, Usama Ramadan
A1  - Pimentel-Elardo, Sheila M.
A1  - Hanora, Amro
A1  - Radwan, Mona
A1  - Abou-El-Ela, Soad H.
A1  - Ahmed, Safwat
A1  - Hentschel, Ute
T1  - Isolation, Phylogenetic Analysis and Anti-infective Activity Screening of Marine Sponge-Associated Actinomycetes
N2  - Terrestrial actinomycetes are noteworthy producers of a multitude of antibiotics, however the marine representatives are much less studied in this regard. In this study, 90 actinomycetes were isolated from 11 different species of marine sponges that had been collected from offshore Ras Mohamed (Egypt) and from Rovinj (Croatia). Phylogenetic characterization of the isolates based on 16S rRNA gene sequencing supported their assignment to 18 different actinomycete genera representing seven different suborders. Fourteen putatively novel species were identified based on sequence similarity values below 98.2% to other strains in the NCBI database. A putative new genus related to Rubrobacter was isolated on M1 agar that had been amended with sponge extract, thus highlighting the need for innovative cultivation protocols. Testing for anti-infective activities was performed against clinically relevant, Gram-positive (Enterococcus faecalis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, fungi (Candida albicans) and human parasites (Leishmania major, Trypanosoma brucei). Bioactivities against these pathogens were documented for 10 actinomycete isolates. These results show a high diversity of actinomycetes associated with marine sponges as well as highlight their potential to produce anti-infective agents.
KW  - Biologie
KW  - actinomycetes
KW  - marine sponges
KW  - anti-infective
KW  - anti-parasitic
KW  - phylogenetic
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-68307
ER  -