TY  - JOUR
A1  - Mohme, Sophia
A1  - Schmalzing, Marc
A1  - Müller, Cornelia S.L.
A1  - Vogt, Thomas
A1  - Goebeler, Matthias
A1  - Stoevesandt, Johanna
T1  - Immunizations in immunocompromised patients: a guide for dermatologists
JF  - JDDG: Journal der Deutschen Dermatologischen Gesellschaft
N2  - The increasingly frequent use of immunomodulatory agents in dermatology requires the observance of specific recommendations for immunization. These recommendations are developed and regularly updated by the German Standing Committee on Vaccination (STIKO), an independent advisory group at the Robert Koch Institute. Dermatological patients on immunosuppressive treatment should ideally receive all vaccinations included in the standard immunization schedule. Additionally, it is recommended that they also undergo vaccination against the seasonal flu, pneumococci, and herpes zoster (inactivated herpes zoster subunit vaccine for patients ≥ 50 years). Additional immunizations against Haemophilus influenzae type B, hepatitis B and meningococci may be indicated depending on individual comorbidities and exposure risk. Limitations of use, specific contraindications and intervals to be observed between vaccination and immunosuppression depend on the immunosuppressive agent used and its dosing. Only under certain conditions may live‐attenuated vaccines be administered in patients on immunosuppressive therapy. Given its strong suppressive effect on the humoral immune response, no vaccines – except for flu shots – should be given within six months after rituximab therapy.
This CME article presents current recommendations on immunization in immunocompromised individuals, with a special focus on dermatological patients. Its goal is to enable readers to provide competent counseling and to initiate necessary immunizations in this vulnerable patient group.
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-217982
VL  - 18
IS  - 7
SP  - 699
EP  - 723
ER  - 
TY  - JOUR
A1  - Trautmann, Axel
A1  - Brockow, Knut
A1  - Stoevesandt, Johanna
T1  - Metamizole‐induced reactions as a paradigm of drug hypersensitivity: Non‐allergic reactions, anaphylaxis, and delayed‐type allergy
JF  - Clinical & Experimental Allergy
KW  - agranulocytosis
KW  - aspirin‐exacerbated respiratory disease
KW  - drug adverse reaction
KW  - drug allergy
KW  - drug hypersensitivity
KW  - exanthem
KW  - fixed drug eruption
KW  - urticaria
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-217997
VL  - 50
IS  - 9
SP  - 1103
EP  - 1106
ER  - 
TY  - JOUR
A1  - Reichel, Alexandra
A1  - Röding, Kristina
A1  - Stoevesandt, Johanna
A1  - Trautmann, Axel
T1  - De‐labelling antibiotic allergy through five key questions
JF  - Clinical & Experimental Allergy
KW  - allergy
KW  - antibiotic
KW  - algorithm
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-215508
VL  - 50
IS  - 4
SP  - 532
EP  - 535
ER  - 
TY  - JOUR
A1  - Schrüfer, Philipp
A1  - Brockow, Knut
A1  - Stoevesandt, Johanna
A1  - Trautmann, Axel
T1  - Predominant patterns of beta-lactam hypersensitivity in a single German Allergy Center: exanthem induced by aminopenicillins, anaphylaxis by cephalosporins
JF  - Allergy, Asthma & Clinical Immunology
N2  - Background 
Penicillins and other beta-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific beta-lactams are scarce and inconsistent. We aimed to determine patterns of beta-latam allergy, i.e. the association of a clinical reaction type with a specific beta-lactam antibiotic. 

Methods 
We retrospectively evaluated data from 800 consecutive patients with suspected beta-lactam hypersensitivity over a period of 11 years in a single German Allergy Center. 

Results 
beta-lactam hypersensitivity was definitely excluded in 595 patients, immediate-type (presumably IgE-mediated) hypersensitivity was diagnosed in 70 and delayed-type hypersensitivity in 135 cases. Most (59 out of 70, 84.3%) immediate-type anaphylactic reactions were induced by a limited number of cephalosporins. Delayed reactions were regularly caused by an aminopenicillin (127 out of 135, 94.1%) and usually manifested as a measles-like exanthem (117 out of 135, 86.7%). Intradermal testing proved to be the most useful method for diagnosing beta-lactam allergy, but prick testing was already positive in 24 out of 70 patients with immediate-type hypersensitivity (34.3%). Patch testing in addition to intradermal testing did not provide additional information for the diagnosis of delayed-type hypersensitivity. Almost all beta-lactam allergic patients tolerated at least one, usually several alternative substances out of the beta-lactam group. 

Conclusions 
We identified two patterns of beta-lactam hypersensitivity: aminopenicillin-induced exanthem and anaphylaxis triggered by certain cephalosporins. Intradermal skin testing was the most useful method to detect both IgE-mediated and delayed-type beta-lactam hypersensitivity.
KW  - amoxicillin
KW  - ampicillin
KW  - angioedema
KW  - drug adverse reaction
KW  - drug allergy
KW  - drug hypersensitivity
KW  - penicillin allergy
KW  - penicillin hypersensitivity
KW  - urticaria
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-231306
VL  - 16
ER  -