TY  - JOUR
A1  - Liedert, Astrid
A1  - Nemitz, Claudia
A1  - Haffner-Luntzer, Melanie
A1  - Schick, Fabian
A1  - Jakob, Franz
A1  - Ignatius, Anita
T1  - Effects of estrogen receptor and Wnt signaling activation on mechanically induced bone formation in a mouse model of postmenopausal bone loss
JF  - International Journal of Molecular Sciences
N2  - In the adult skeleton, bone remodeling is required to replace damaged bone and functionally adapt bone mass and structure according to the mechanical requirements. It is regulated by multiple endocrine and paracrine factors, including hormones and growth factors, which interact in a coordinated manner. Because the response of bone to mechanical signals is dependent on functional estrogen receptor (ER) and Wnt/β-catenin signaling and is impaired in postmenopausal osteoporosis by estrogen deficiency, it is of paramount importance to elucidate the underlying mechanisms as a basis for the development of new strategies in the treatment of osteoporosis. The present study aimed to investigate the effectiveness of the activation of the ligand-dependent ER and the Wnt/β-catenin signal transduction pathways on mechanically induced bone formation using ovariectomized mice as a model of postmenopausal bone loss. We demonstrated that both pathways interact in the regulation of bone mass adaption in response to mechanical loading and that the activation of Wnt/β-catenin signaling considerably increased mechanically induced bone formation, whereas the effects of estrogen treatment strictly depended on the estrogen status in the mice.
KW  - bone remodeling
KW  - mechanotransduction
KW  - ER signaling
KW  - Wnt/β-catenin signaling
KW  - ovariectomy
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-285487
SN  - 1422-0067
VL  - 21
IS  - 21
ER  - 
TY  - JOUR
A1  - Kauffmann, Frederic
A1  - Höhne, Christian
A1  - Assaf, Alexandre Thomas
A1  - Vollkommer, Tobias
A1  - Semmusch, Jan
A1  - Reitmeier, Aline
A1  - Stein, Jamal Michel
A1  - Heiland, Max
A1  - Smeets, Ralf
A1  - Rutkowski, Rico
T1  - The influence of local pamidronate application on alveolar dimensional preservation after tooth extraction — an animal experimental study
JF  - International Journal of Molecular Sciences
N2  - The aim of this randomized, controlled animal exploratory trial was to investigate the influence of local application of aminobisphosphonate pamidronate during the socket preservation procedure. Mandibular premolars were extracted in five Göttingen minipigs. Two animals underwent socket preservation using BEGO OSS (n = 8 sockets) and three animals using BEGO OSS + Pamifos (15 mg) (n = 12 sockets). After jaw impression, cast models (baseline, eight weeks postoperative) were digitized using an inLab X5 scanner (Dentsply Sirona) and the generated STL data were superimposed and analyzed with GOM Inspect 2018 (GOM, Braunschweig). After 16 weeks, the lower jaws were prepared and examined using standard histological methods. In the test group (BEGO OSS + pamidronate), buccooral dimensional loss was significantly lower, both vestibulary (−0.80 ± 0.57 mm vs. −1.92 ± 0.63 mm; p = 0.00298) and lingually (−1.36 ± 0.58 mm vs. −2.56 ± 0.65 mm; p = 0.00104) compared with the control group (BEGO OSS). The test group showed a significant difference between vestibular and lingual dimensional loss (p = 0.04036). Histology showed cortical and cancellous bone in the alveolar sockets without signs of local inflammation. Adjuvant application of pamidronate during socket preservation reduces alveolar dimensional loss significantly. Further investigations with regard to dose–response relationships, volume effects, side effects, and a verification of the suitability in combination with other bone substitute materials (BSMs) are necessary.
KW  - pamidronate
KW  - socket preservation
KW  - ridge preservation
KW  - bone remodeling
KW  - bone regeneration
KW  - bisphosphonates
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-285173
SN  - 1422-0067
VL  - 21
IS  - 10
ER  -